CAJ | 학술논문

目的探讨在中国汉族人群青少年肥胖合并黑棘皮病患者的临床特征,分析黑棘皮病与胰岛素抵抗及脂肪细胞因子的关系.方法将135例青少年肥胖患者及20名健康志愿者分为黑棘皮病组,单纯肥胖组及对照组,在3组人群中进行临床基本指标、口服葡萄糖耐量试验及血浆脂肪因子测定.结果在135例青少年肥胖患者中黑棘皮病患者占44.4％,黑棘皮病组体重、体重指数、腰围、臀围、腰臀比等明显升高.黑棘皮病组胰岛素敏感性指数明显低于单纯肥胖组,而空腹胰岛素及胰岛素抵抗指数明显升高.与对照组相比,黑棘皮病组及单纯肥胖组chemerin、瘦素水平显著升高；黑棘皮病组瘦素水平明显高于单纯肥胖组,而chemerin水平在两组之间差异无明显统计学意义.结论在中国青少年肥胖人群中,黑棘皮病是严重肥胖及严重胰岛素抵抗的标志；黑棘皮病的发生与高胰岛素水平明显相关,而瘦素水平与AN的发生也有一定的关联.
목적 탐토재중국한족인군청소년비반합병흑극피병환자적림상특정,분석흑극피병여이도소저항급지방세포인자적관계.방법 장135례청소년비반환자급20명건강지원자분위흑극피병조,단순비반조급대조조,재3조인군중진행림상기본지표、구복포도당내량시험급혈장지방인자측정.결과 재135례청소년비반환자중흑극피병환자점44.4％,흑극피병조체중、체중지수、요위、둔위、요둔비등명현승고.흑극피병조이도소민감성지수명현저우단순비반조,이공복이도소급이도소저항지수명현승고.여대조조상비,흑극피병조급단순비반조chemerin、수소수평현저승고；흑극피병조수소수평명현고우단순비반조,이chemerin수평재량조지간차이무명현통계학의의.결론 재중국청소년비반인군중,흑극피병시엄중비반급엄중이도소저항적표지；흑극피병적발생여고이도소수평명현상관,이수소수평여AN적발생야유일정적관련.
Objective To investigate the clinical characteristics,insulin resistance,and levels of adipokines in obese adolescents with acanthosis nigricans.Methods One hundred and thirty-five obese adolescents and 20 healthy participants were selected.All participants were divided into 3 groups with regard to the acanthosis nigricans:the acanthosis nigricans (AN)group,the simple obesity (Ob)group,and the control group.The clinical characteristics,results of OGTT test and levels of serum adipokines in the participants were recorded.Results The incidence of AN in obese adolescents was 44.4％.Body weight,body mass index,waist circumference,hip circumference,and waist-to-hip ratio were higher in the AN group.Insulin action index (IAI) in the AN group was lower than that in the OB group and control group.However,the level of fasting insulin and HOMA-IR was higher.The level of leptin was higher in the AN group than that in OB group and control group.However,the level of chemerin between the AN group and OB group was similar.Conclusions s AN was a biomarker of severe obesity and insulin resistance in obese adolescents.Higher levels of insulin and leptin might play an important role in the process of AN.