中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2013年
8期
674-678
,共5页
周竟雄%施亚雄%林家煜%梁波%陈晓毓%林夏鸿%李希圣%洪玉
週竟雄%施亞雄%林傢煜%樑波%陳曉毓%林夏鴻%李希聖%洪玉
주경웅%시아웅%림가욱%량파%진효육%림하홍%리희골%홍옥
糖尿病,2型%原发性青光眼%危险因素
糖尿病,2型%原髮性青光眼%危險因素
당뇨병,2형%원발성청광안%위험인소
Diabetes mellitus,type 2%Primary glaucoma%Risk factors
目的 通过分析临床资料,探讨2型糖尿病患者发生原发性青光眼的危险因素.方法 选取住院患者167例,2型糖尿病并原发性青光眼组61例；2型糖尿病无青光眼组60例；原发性青光眼无糖尿病组46例.检测血压、血糖、血脂、HbA1C、眼内压、尿白蛋白排泄率、颈动脉内膜中层厚度.采用x2检验、方差分析、t检验和相关分析进行数据统计.结果 2型糖尿病并原发性青光眼患者(1)平均年龄(63.4±12.2)岁；原发性开角型青光眼(POAG) 13例占21.3％,原发性闭角型青光眼(PACG) 48例占78.7％.(2)收缩压和眼内压高于2型糖尿病无青光眼组[分别是(142±17对132±18)mm Hg(1 mm Hg=0.133 kPa)；(38.0±2.3对14.6±2.5)mm Hg,均P＜0.01].(3)女性收缩压和眼内压高于男性[分别是(145±16对136±17)mm Hg;(41.9±15.2对33.2±11.0)mm Hg,均P＜0.05].(4)代谢综合征患者收缩压和眼内压高于非代谢综合征者[分别是(147±16对137±17)mm Hg;(40.8±17.4对36.0±11.6)mm Hg,均P＜0.05].(5)眼内压与收缩压、尿白蛋白排泄率正相关(分别是r=0.21,P＜0.01;r=0.25,P＜0.05)；校正收缩压后,眼内压与尿白蛋白排泄率不相关.结论 住院2型糖尿病并原发性青光眼患者多为闭角型青光眼,致肓率高；老年、女性、高收缩压、代谢综合征可能是糖尿病并原发性青光眼的危险因素.
目的 通過分析臨床資料,探討2型糖尿病患者髮生原髮性青光眼的危險因素.方法 選取住院患者167例,2型糖尿病併原髮性青光眼組61例；2型糖尿病無青光眼組60例；原髮性青光眼無糖尿病組46例.檢測血壓、血糖、血脂、HbA1C、眼內壓、尿白蛋白排洩率、頸動脈內膜中層厚度.採用x2檢驗、方差分析、t檢驗和相關分析進行數據統計.結果 2型糖尿病併原髮性青光眼患者(1)平均年齡(63.4±12.2)歲；原髮性開角型青光眼(POAG) 13例佔21.3％,原髮性閉角型青光眼(PACG) 48例佔78.7％.(2)收縮壓和眼內壓高于2型糖尿病無青光眼組[分彆是(142±17對132±18)mm Hg(1 mm Hg=0.133 kPa)；(38.0±2.3對14.6±2.5)mm Hg,均P＜0.01].(3)女性收縮壓和眼內壓高于男性[分彆是(145±16對136±17)mm Hg;(41.9±15.2對33.2±11.0)mm Hg,均P＜0.05].(4)代謝綜閤徵患者收縮壓和眼內壓高于非代謝綜閤徵者[分彆是(147±16對137±17)mm Hg;(40.8±17.4對36.0±11.6)mm Hg,均P＜0.05].(5)眼內壓與收縮壓、尿白蛋白排洩率正相關(分彆是r=0.21,P＜0.01;r=0.25,P＜0.05)；校正收縮壓後,眼內壓與尿白蛋白排洩率不相關.結論 住院2型糖尿病併原髮性青光眼患者多為閉角型青光眼,緻肓率高；老年、女性、高收縮壓、代謝綜閤徵可能是糖尿病併原髮性青光眼的危險因素.
목적 통과분석림상자료,탐토2형당뇨병환자발생원발성청광안적위험인소.방법 선취주원환자167례,2형당뇨병병원발성청광안조61례；2형당뇨병무청광안조60례；원발성청광안무당뇨병조46례.검측혈압、혈당、혈지、HbA1C、안내압、뇨백단백배설솔、경동맥내막중층후도.채용x2검험、방차분석、t검험화상관분석진행수거통계.결과 2형당뇨병병원발성청광안환자(1)평균년령(63.4±12.2)세；원발성개각형청광안(POAG) 13례점21.3％,원발성폐각형청광안(PACG) 48례점78.7％.(2)수축압화안내압고우2형당뇨병무청광안조[분별시(142±17대132±18)mm Hg(1 mm Hg=0.133 kPa)；(38.0±2.3대14.6±2.5)mm Hg,균P＜0.01].(3)녀성수축압화안내압고우남성[분별시(145±16대136±17)mm Hg;(41.9±15.2대33.2±11.0)mm Hg,균P＜0.05].(4)대사종합정환자수축압화안내압고우비대사종합정자[분별시(147±16대137±17)mm Hg;(40.8±17.4대36.0±11.6)mm Hg,균P＜0.05].(5)안내압여수축압、뇨백단백배설솔정상관(분별시r=0.21,P＜0.01;r=0.25,P＜0.05)；교정수축압후,안내압여뇨백단백배설솔불상관.결론 주원2형당뇨병병원발성청광안환자다위폐각형청광안,치황솔고；노년、녀성、고수축압、대사종합정가능시당뇨병병원발성청광안적위험인소.
Objective To explore the risk factors from clinical data in type 2 diabetic patients complicated with primary glaucoma.Methods A total of 167 hospitalized patients were included,including 61 type 2 diabetic patients with primary glaucoma (DM-PG),60 diabetic patients without glaucoma(DM-WG) and 46 age and gendermatched isolated primary glaucoma (I-PG) patients.Blood pressure,intraocular pressure (IOP),fasting plasma glucose(FPG),blood lipid,urinary albumin excretion rate (UAER),and carotid artery intima-median thickness (CIMT) were measured in all of the patients.Results In the DM-PG group,(1) The mean age was (63.4 ± 12.2)years.13 (21.3％) patients had primary open-angle glaucoma (POAG),48 patients (78.7％) had primary angleclosur glaucoma (PACG).(2) Systolic blood pressure (SBP) and IOP were both significantly higher than those in DMWG group [(142 ± 17 vs 132 ± 18) mm Hg (1 mm Hg =0.133 kPa) ; (38.0 ± 2.3 vs 14.6± 2.5) mm Hg,respectively;both P＜0.01].(3) SBP and IOP in female patients were higher than those in male [(145 ± 16 vs 136 ± 17) mm Hg;(41.9 ± 15.2 vs 33.2 ± 11.0) mm Hg,respectively ; both P ＜0.05].(4) SBP and IOP in patients with metabolic syndrome were higher than those in patients without metabolic syndrome[(147± 16 vs 137 ± 17) mm Hg,(40.8 ± 17.4 vs 36.0 ± 11.6) mm Hg,respectively ; both P＜0.05].(5) IOP had a positive correlation with SBP and UAER (r =0.21,P＜0.01; r =0.25,P＜0.05,respectively).After a correction in SBP,IOP was not associated with UAER.Conclusions PACG is the major type of glaucoma in type 2 diabetic patients complicated with primary glaucoma,with a fairly high rate of blindness.Old age,female,higher SBP,and metabolic syndrome may be considered as risk factors of type 2 diabetic patients complicated with primary glaucoma.
