CAJ | 학술논문

二甲双胍是治疗2型糖尿病的一线药物.二甲双胍除了具有理想的降糖作用外,还具有一定的心血管保护效应,其中包括预防动脉粥样硬化的发生和发展、降低心血管事件风险、减轻心肌缺血-再灌注损伤、抑制心肌重构、延缓心力衰竭进展等.激活腺苷酸活化的蛋白激酶(AMPK)信号通路在二甲双胍的心血管保护作用中起着至关重要的作用.
이갑쌍고시치료2형당뇨병적일선약물.이갑쌍고제료구유이상적강당작용외,환구유일정적심혈관보호효응,기중포괄예방동맥죽양경화적발생화발전、강저심혈관사건풍험、감경심기결혈-재관주손상、억제심기중구、연완심력쇠갈진전등.격활선감산활화적단백격매(AMPK)신호통로재이갑쌍고적심혈관보호작용중기착지관중요적작용.
Metformin has been recommended as the first-line therapy for type 2 diabetes.Besides its ideal glucose-lowering effect,metformin has also been shown to exert beneficial effects on cardiovascular system,including preventing the occurrence and progression of atherosclerosis,reducing risk for cardiovascular events,attenuating myocardial ischemia-reperfusion injury,improving ventricular remodeling,and slowing the progress of heart failure.The activation of adenosine monophosphate activated protein kinase (AMPK) signaling pathway plays a pivotal role in the protective cardiovascular effects resulted from metformin.