CAJ | 학술논문

选取42例2型糖尿病患者(DM组)、23例糖尿病合并不稳定型心绞痛患者(DM+UAP组)和36名正常健康者(对照组).收集血清,然后使用蛋白芯片检测血清中血管内皮生长因子(VEGF)、血管形成蛋白(Ang)-1、Ang-2、血管生成素、血管抑制素、碱性成纤维细胞生长因子和血小板源性生长因子BB浓度.结果显示,DM组与对照组比较,所有7个因子的血清浓度差异均无统计学意义,而DM+UAP组Ang-2和VEGF水平较对照组显著增高[(3 532.10±1 813.72对2444.50±1 152.21)pg/ml,(286.90±217.01对171.92±106.63)pg/ml,均P＜0.01].7个血管生成因子浓度与HbA1C、空腹血糖、餐后2h血糖、甘油三酯、高密度脂蛋白胆同醇和低密度脂蛋白胆固醇均无显著相关.
선취42례2형당뇨병환자(DM조)、23례당뇨병합병불은정형심교통환자(DM+UAP조)화36명정상건강자(대조조).수집혈청,연후사용단백심편검측혈청중혈관내피생장인자(VEGF)、혈관형성단백(Ang)-1、Ang-2、혈관생성소、혈관억제소、감성성섬유세포생장인자화혈소판원성생장인자BB농도.결과현시,DM조여대조조비교,소유7개인자적혈청농도차이균무통계학의의,이DM+UAP조Ang-2화VEGF수평교대조조현저증고[(3 532.10±1 813.72대2444.50±1 152.21)pg/ml,(286.90±217.01대171.92±106.63)pg/ml,균P＜0.01].7개혈관생성인자농도여HbA1C、공복혈당、찬후2h혈당、감유삼지、고밀도지단백담동순화저밀도지단백담고순균무현저상관.
Forty-two patients with type 2 diabetes (DM group),23 type 2 diabetic patients with unstable angina pectoris (DM + UAP group),and 36 healthy subjects (control group) were enrolled in this study.Serum samples were collected for determining serum concentrations of vascular endothelial growth factor (VEGF),Angiopoietin (Ang)-1,Ang-2,angiogenin,angiostatin,basic fibroblast growth factor,and platelet-derived growth factor-BB using protein array technology.The results showed that there were no significant differences in serum concentrations of all 7 angiogenic factors between control group and DM group.Whereas,serum concentrations of V EGF and Ang-2 were significantly increased in DM + UAP group compared with control group [(3 532.10 ± 1 813.72vs 2 444.50 ± 1 152.21) pg/ml,(286.90-± 217.01 vs 171.92 ± 106.63) pg/ml,both P＜0.01].Pearson's correlation analysis revealed that serum concentrations of all 7 angiogenic factors were not related to HbA1C,fasting and 2 h postprandial plasma glucose,triglycerides,high density lipoprotein cholesterol,as well as low density lipoprotein cholesterol.