CAJ | 학술논문

选取209例2型糖尿病患者,根据踝肱指数(ABI)分为单纯2型糖尿病组、2型糖尿病伴轻中度闭塞组、2型糖尿病伴重度闭塞组,以60名健康体检者作为对照组.检测血清视黄醇结合蛋白4(RBP4)、胱抑素C和生化指标.结果显示,各组间血清RBP4、胱抑素C水平随下肢动脉病变程度逐渐升高,2型糖尿病伴中度和重度闭塞组显著高于对照组(P＜0.05或P＜0.01),伴下肢动脉病变组RBP4、胱抑素C水平显著高于不伴下肢动脉病变组(均P＜0.01).Pearson相关分析结果显示总胆固醇、甘油三酯、低密度脂蛋白胆固醇、体重指数、腰臀比、胱抑素C等与血清RBP4呈正相关,与高密度脂蛋白胆固醇呈负相关(P＜0.05或P＜0.01).Logistic回归分析发现血清RBP4、胱抑素C与2型糖尿病下肢动脉病变显著相关(P＜0.05或P＜0.01).
선취209례2형당뇨병환자,근거과굉지수(ABI)분위단순2형당뇨병조、2형당뇨병반경중도폐새조、2형당뇨병반중도폐새조,이60명건강체검자작위대조조.검측혈청시황순결합단백4(RBP4)、광억소C화생화지표.결과현시,각조간혈청RBP4、광억소C수평수하지동맥병변정도축점승고,2형당뇨병반중도화중도폐새조현저고우대조조(P＜0.05혹P＜0.01),반하지동맥병변조RBP4、광억소C수평현저고우불반하지동맥병변조(균P＜0.01).Pearson상관분석결과현시총담고순、감유삼지、저밀도지단백담고순、체중지수、요둔비、광억소C등여혈청RBP4정정상관,여고밀도지단백담고순정부상관(P＜0.05혹P＜0.01).Logistic회귀분석발현혈청RBP4、광억소C여2형당뇨병하지동맥병변현저상관(P＜0.05혹P＜0.01).
A total of 209 type 2 diabetic patients were divided into three groups:without,with mild to moderate,or severe diabetic lower extremity arterial disease based on the ankle brachial index value.60 healthy subjects were used as a control group.Retinol binding protein4 (RBP4),cystatin C,and biochemical parameters were determined in all subjects.The results showed that RBP4 and cystatin C levels were progressively raised with the increasing severity of lower extremity arterial disease in various groups,being significantly higher in patients with type 2 diabetes mellitus with mild to moderate and severe arterial disease compared with control group (P＜0.05 or P＜0.01).RBP4 and cystatin C levels in groups with lower extremity arterial disease were significantly higher than those in the group without arterial disease (P＜0.01).Pearson correlation analysis showed that RBP4 level was positively correlated with total cholesterol,triglyceride,low density lipoprotein-cholesterol,fasting serum insulin,body mass index,cystatin C etc while negatively correlated with high density lipoprotein-cholesterol (P＜0.05 or P＜0.01).Logistic regression analysis showed that serum RBP4 and cystatin C were significantly associated with lower extremity arterial disease in type 2 diabetes mellitus.