CAJ | 학술논문

目的分析红细胞压积(hematocrit,HCT)与非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)发病的相关性.方法采用观察性的队列研究,选取2006年在江苏省徐州市中心医院体检的2 798名未患有NAFLD的健康人群为研究对象,按照红细胞压积的水平分成2组,A组:HCT≤0.49L/L,B组;HCT＞0.49 L/L,经过5年随访,观察2011年NAFLD的发病情况.检测研究对象的血清谷丙转氨酶、谷草转氨酶、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、空腹血糖等相关生化指标和影像学检查结果.结果 B组NAFLD的发病率明显大于A组,A组发病率15.9％,B组发病率26.5％ (P＜0.01),2组发病率之间差异有统计学意义.Logistic回归分析显示,随着HCT的增高,发生NAFLD的风险也随之增高.结论红细胞压积与NAFLD的发病存在一定的相关性,可以作为评估患者是否可能发生NAFLD的指标.
목적 분석홍세포압적(hematocrit,HCT)여비주정성지방성간병(nonalcoholic fatty liver disease,NAFLD)발병적상관성.방법 채용관찰성적대렬연구,선취2006년재강소성서주시중심의원체검적2 798명미환유NAFLD적건강인군위연구대상,안조홍세포압적적수평분성2조,A조:HCT≤0.49L/L,B조;HCT＞0.49 L/L,경과5년수방,관찰2011년NAFLD적발병정황.검측연구대상적혈청곡병전안매、곡초전안매、감유삼지、총담고순、고밀도지단백담고순、저밀도지단백담고순、공복혈당등상관생화지표화영상학검사결과.결과 B조NAFLD적발병솔명현대우A조,A조발병솔15.9％,B조발병솔26.5％ (P＜0.01),2조발병솔지간차이유통계학의의.Logistic회귀분석현시,수착HCT적증고,발생NAFLD적풍험야수지증고.결론 홍세포압적여NAFLD적발병존재일정적상관성,가이작위평고환자시부가능발생NAFLD적지표.
Objective To investigate the relationship between hematocrit(HCT) and the risk of nonalcoholic fatty liver disease.Methods A community-based health examination survey in individuals who were randomly selected from residents living in the urban area of Xuzhou was carried out in 2006.2 798 subjects without nonalcoholic fatty liver disease were included in the present study.Subjects were divided into two groups according to HCT level,group A (HCT ≤ 0.49 L/L) and group B (HCT ＞ 0.49 L/L).Serum alanine aminotransferase,aspartate aminotransferase,triglycerides,total cholesterol,high density lipoprotein-cholesterol,low density lipoproteincholesterol,fasting plasma glucose,and imaging examinations were determined.Results The prevalence of nonalcoholic fatty liver disease was higher in group B than that in group A (26.5％ vs 15.9％,P＜0.01),and the difference was statistically significant.Logistic regression showed that the incidence of nonalcoholic fatty liver disease was increased along with elevated levels of HCT.Conclusions HCT is found to be correlated with the prevalence of nonalcoholic fatty liver disease.