中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2014年
1期
26-30
,共5页
王珊珊%陈莉明%常宝成%杨菊红%徐延光%郑妙艳%王颖%任惠珠%赵然
王珊珊%陳莉明%常寶成%楊菊紅%徐延光%鄭妙豔%王穎%任惠珠%趙然
왕산산%진리명%상보성%양국홍%서연광%정묘염%왕영%임혜주%조연
血清校正钙浓度%胰岛β细胞%HbA1C%糖尿病,2型
血清校正鈣濃度%胰島β細胞%HbA1C%糖尿病,2型
혈청교정개농도%이도β세포%HbA1C%당뇨병,2형
Corrected serum calcium%Pancreatic β-cell%HbA1C%Diabetes mellitus,type 2
目的 了解2型糖尿病患者血清钙与糖代谢的相关关系.方法 肾功能正常的2型糖尿病患者302例按HbA1C水平分为3组:血糖控制较好组(HbA1C≤7.0％,96例),血糖控制一般组(7.0％＜HbA1C≤9.0％,134例),血糖控制差组(HbA1C＞9.0％,72例).比较各组间血清校正钙浓度(CsCa)的差异,并对不同HbA1C水平下CsCa与胰岛素抵抗、胰岛β细胞功能、HbA1C、空腹血糖等指标行相关和回归分析.结果 (1)血糖控制差组CsCa[(2.26±0.12对2.22±0.09、2.21±0.11)mmol/L]和碱性磷酸酶水平高于血糖控制较好、一般组(均P＜0.05),空腹胰岛素、稳态模型评估的胰岛β细胞功能指数(HOMA-β)均降低(均P＜0.05).(2)在血糖控制较好组中,多元逐步回归分析显示,CsCa与股骨骨密度呈负相关(P＜0.01),与胰岛素敏感指数、总胆固醇呈正相关(P＜0.05).(3)在血糖控制一般组中,稳态模型评估的胰岛素抵抗指数(HOMA-IR)与CsCa呈负相关(P＜0.01).(4)在血糖控制差组中,多元逐步回归分析显示,CsCa与尿酸、HOMA-β呈负相关(P＜0.01),与HbA1C呈正相关(P＜0.01).结论 2型糖尿病患者CsCa与血糖控制状况、胰岛素抵抗、胰岛β细胞功能密切相关.
目的 瞭解2型糖尿病患者血清鈣與糖代謝的相關關繫.方法 腎功能正常的2型糖尿病患者302例按HbA1C水平分為3組:血糖控製較好組(HbA1C≤7.0％,96例),血糖控製一般組(7.0％＜HbA1C≤9.0％,134例),血糖控製差組(HbA1C＞9.0％,72例).比較各組間血清校正鈣濃度(CsCa)的差異,併對不同HbA1C水平下CsCa與胰島素牴抗、胰島β細胞功能、HbA1C、空腹血糖等指標行相關和迴歸分析.結果 (1)血糖控製差組CsCa[(2.26±0.12對2.22±0.09、2.21±0.11)mmol/L]和堿性燐痠酶水平高于血糖控製較好、一般組(均P＜0.05),空腹胰島素、穩態模型評估的胰島β細胞功能指數(HOMA-β)均降低(均P＜0.05).(2)在血糖控製較好組中,多元逐步迴歸分析顯示,CsCa與股骨骨密度呈負相關(P＜0.01),與胰島素敏感指數、總膽固醇呈正相關(P＜0.05).(3)在血糖控製一般組中,穩態模型評估的胰島素牴抗指數(HOMA-IR)與CsCa呈負相關(P＜0.01).(4)在血糖控製差組中,多元逐步迴歸分析顯示,CsCa與尿痠、HOMA-β呈負相關(P＜0.01),與HbA1C呈正相關(P＜0.01).結論 2型糖尿病患者CsCa與血糖控製狀況、胰島素牴抗、胰島β細胞功能密切相關.
목적 료해2형당뇨병환자혈청개여당대사적상관관계.방법 신공능정상적2형당뇨병환자302례안HbA1C수평분위3조:혈당공제교호조(HbA1C≤7.0％,96례),혈당공제일반조(7.0％＜HbA1C≤9.0％,134례),혈당공제차조(HbA1C＞9.0％,72례).비교각조간혈청교정개농도(CsCa)적차이,병대불동HbA1C수평하CsCa여이도소저항、이도β세포공능、HbA1C、공복혈당등지표행상관화회귀분석.결과 (1)혈당공제차조CsCa[(2.26±0.12대2.22±0.09、2.21±0.11)mmol/L]화감성린산매수평고우혈당공제교호、일반조(균P＜0.05),공복이도소、은태모형평고적이도β세포공능지수(HOMA-β)균강저(균P＜0.05).(2)재혈당공제교호조중,다원축보회귀분석현시,CsCa여고골골밀도정부상관(P＜0.01),여이도소민감지수、총담고순정정상관(P＜0.05).(3)재혈당공제일반조중,은태모형평고적이도소저항지수(HOMA-IR)여CsCa정부상관(P＜0.01).(4)재혈당공제차조중,다원축보회귀분석현시,CsCa여뇨산、HOMA-β정부상관(P＜0.01),여HbA1C정정상관(P＜0.01).결론 2형당뇨병환자CsCa여혈당공제상황、이도소저항、이도β세포공능밀절상관.
Objective To investigate the correlation between serum calcium and glucose metabolism in patients with type 2 diabetes mellitus.Methods Three hundred and two cases of type 2 diabetics with normal renal function were divided into three groups according to their HbA1C levels:Better glycemic control group (HbA1C ≤7.0％),moderate glycemic control group (7.0％ ＜ HbA1C ≤ 9.0％),and poor glycemic control group (HbA1C ＞9.0％).Corrected serum calcium (CsCa) from the three groups were observed and compared and the correlation analysis and multiple stepwise regression were used to examine the correlations between CsCa and other indicators such as insulin resistance,pancreatic β cell function,HbA1C,and fasting plasma glucose.Results (1) Compared with better glycemic control group and moderate glycemic control group,the levels of CsCa [(2.26 ±0.12 vs 2.22 ±0.09,2.21 ± 0.11) mmol/L] and alkaline phosphatase in poor glycemic control group were higher while the levels of fasting insulin and homeostasis model assessment of β cell function (HOMA-β) were significantly lower (all P＜0.05).(2)In better glycemic control group,CsCa was negatively correlated with femur bone mineral density (P＜0.01) and positively correlated with insulin sensitivity index and total cholesterol (P ＜ 0.05) by multiple stepwise regression analysis.(3) In moderate glycemic control group,CsCa was negatively correlated with homeostasis model assessment of insulin resistance index (P＜0.01).(4) In poor glycemic control group,multiple stepwise analysis indicated that CsCa was negatively correlated with uric acid and HOMA-β (P＜0.01) and positively correlated with HbA1C (P＜0.01).Conclusions CsCa is closely correlated with the levels of glycemic control,insulin resistance,and pancreatic β cell function in patients with type 2 diabetes mellitus.
