CAJ | 학술논문

目的研究产后1年内血清瘦素水平的变化与产后甲状腺炎(PPT)发生的关系.方法以57例PPT患者(临床PPT 34例,亚临床PPT 23例)为病例组,37名健康产后女性为对照组.收集其产后3d和3、6、12个月的血清标本,采用放射免疫分析法测定瘦素水平.结果与对照组相比,病例组在产后1年内保持较高水平的瘦素和瘦素/体重指数(LEP/BMI)比值,差异具有统计学意义(P＜0.05或P＜0.01).临床PPT患者和亚临床PPT患者相比,产后1年内各时间点的瘦素和LEP/BMI比值差异无统计学意义.病例组瘦素和LEP/BMI比值与TSH呈负相关,与FT3和FT呈正相关.结论产后1年内持续较高水平的瘦素可能与PPT的发生有关,需要进一步的研究来阐明瘦素在PPT发生中的作用.
목적 연구산후1년내혈청수소수평적변화여산후갑상선염(PPT)발생적관계.방법 이57례PPT환자(림상PPT 34례,아림상PPT 23례)위병례조,37명건강산후녀성위대조조.수집기산후3d화3、6、12개월적혈청표본,채용방사면역분석법측정수소수평.결과 여대조조상비,병례조재산후1년내보지교고수평적수소화수소/체중지수(LEP/BMI)비치,차이구유통계학의의(P＜0.05혹P＜0.01).림상PPT환자화아림상PPT환자상비,산후1년내각시간점적수소화LEP/BMI비치차이무통계학의의.병례조수소화LEP/BMI비치여TSH정부상관,여FT3화FT정정상관.결론 산후1년내지속교고수평적수소가능여PPT적발생유관,수요진일보적연구래천명수소재PPT발생중적작용.
Objective To investigate the association of serum leptin (LEP) levels during the first postpartum year with the occurrence of postpartum thyroiditis (PPT).Methods Fifty-seven PPT patients consisted of 34 with overt PPT and 23 subclinical PPT.37 healthy postpartum women were used as controls.Serum samples were obtained at 4 postpartum date points,i.e.3-days and 3,6,12-months postpartum.LEP level was determined by radioimmunoassav.Results Compared with control women,PPT patients were maintaining significantly higher levels of LEP and LEP/body mass index (BMI) ratio during the first postpartum year.There was no significant difference in serum LEP level or LEP/BMI ratio between overt PPT and subclinical PPT groups.In PPT patients,LEP and LEP/BMI ratio were negatively correlated with serum TSH,and positively correlated with serum FT4 and FT3.Conclusion Sustained high levels of serum LEP after delivery may favor the occurrence of PPT.Further studies are needed to clarify the specific role played by LEP in PPT.