CAJ | 학술논문

组蛋白乙酰化是表观遗传学组蛋白修饰的重要内容,组蛋白乙酰化参与糖尿病及其并发症的发生,其机制包括介导高血糖的“代谢记忆”效应、干扰胰岛的发育和调节炎症因子及致病基因的表达等.全基因组关联研究方法正在逐渐揭示糖尿病的发病机制,并且越来越多的研究表明组蛋白去乙酰化酶可以作为糖尿病治疗的新靶点.
조단백을선화시표관유전학조단백수식적중요내용,조단백을선화삼여당뇨병급기병발증적발생,기궤제포괄개도고혈당적“대사기억”효응、간우이도적발육화조절염증인자급치병기인적표체등.전기인조관련연구방법정재축점게시당뇨병적발병궤제,병차월래월다적연구표명조단백거을선화매가이작위당뇨병치료적신파점.
Histone acetylation is a crucial part of histone modifications in epigenetics.Histone acetylation is involved in the onset of diabetes and diabetic complications,through the mechanism of inducing hyperglycemia by means of" metabolic memory" effect,interfering islet development and regulating the expression of inflammatory factors and pathogenic genes.Genome-wide association studies are gradually unveilling the pathogenesis of diabetes and preclinical studies are rapidly elucidating that histone deacetylase should be considered as a new target for the treatment of diabetes.