中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2014年
3期
192-196
,共5页
刘晶%陈宝鑫%王红梅%周春宇%赵晖%朱津浦%张志军%杨秀泉%张志辰
劉晶%陳寶鑫%王紅梅%週春宇%趙暉%硃津浦%張誌軍%楊秀泉%張誌辰
류정%진보흠%왕홍매%주춘우%조휘%주진포%장지군%양수천%장지신
代谢综合征%脑卒中%高危%颈动脉粥样硬化
代謝綜閤徵%腦卒中%高危%頸動脈粥樣硬化
대사종합정%뇌졸중%고위%경동맥죽양경화
Metabolic syndrome%Stroke%High-risk%Carotid atherosclerosis
目的 比较国际糖尿病联盟(IDF,2005年)、美国国家胆固醇教育计划成人治疗指南(NCEP-ATPⅢ)修订版(NCEP-ATPⅢ修订版,2005年)和《中国成人血脂异常防治指南》(血脂指南,2007年)3种代谢综合征诊断标准在脑卒中高危人群中的应用.方法 选择脑卒中高危患者,比较3种标准的诊断差异,并比较不同诊断标准下有无代谢综合征(MS)与颈动脉粥样硬化的关系.结果 应用IDF、NECP-ATPⅢ修订版和“血脂指南”标准,MS患病率分别为61.7％、72.4％和58.9％;MS组颈动脉内中膜增厚(54.3％对50.3％、55.0％对46.8％、57.0％对46.6％,均P＜0.05)及斑块(44.9％对38.7％、45.2％对35.7％、47.8％对35.0％、均P＜0.05)的检出率均显著高于非MS组;随着MS组分数的增加,颈动脉内中膜增厚及斑块检出率逐渐增加(均P＜0.01);3种诊断标准的MS使颈动脉粥样硬化的风险均增强.结论 MS能增加颈动脉粥样硬化患病率,在预测颈动脉内中膜增厚时以NECP-ATPⅢ修订版标准突出,而预测颈动脉斑块时以“血脂指南”标准突出.
目的 比較國際糖尿病聯盟(IDF,2005年)、美國國傢膽固醇教育計劃成人治療指南(NCEP-ATPⅢ)脩訂版(NCEP-ATPⅢ脩訂版,2005年)和《中國成人血脂異常防治指南》(血脂指南,2007年)3種代謝綜閤徵診斷標準在腦卒中高危人群中的應用.方法 選擇腦卒中高危患者,比較3種標準的診斷差異,併比較不同診斷標準下有無代謝綜閤徵(MS)與頸動脈粥樣硬化的關繫.結果 應用IDF、NECP-ATPⅢ脩訂版和“血脂指南”標準,MS患病率分彆為61.7％、72.4％和58.9％;MS組頸動脈內中膜增厚(54.3％對50.3％、55.0％對46.8％、57.0％對46.6％,均P＜0.05)及斑塊(44.9％對38.7％、45.2％對35.7％、47.8％對35.0％、均P＜0.05)的檢齣率均顯著高于非MS組;隨著MS組分數的增加,頸動脈內中膜增厚及斑塊檢齣率逐漸增加(均P＜0.01);3種診斷標準的MS使頸動脈粥樣硬化的風險均增彊.結論 MS能增加頸動脈粥樣硬化患病率,在預測頸動脈內中膜增厚時以NECP-ATPⅢ脩訂版標準突齣,而預測頸動脈斑塊時以“血脂指南”標準突齣.
목적 비교국제당뇨병련맹(IDF,2005년)、미국국가담고순교육계화성인치료지남(NCEP-ATPⅢ)수정판(NCEP-ATPⅢ수정판,2005년)화《중국성인혈지이상방치지남》(혈지지남,2007년)3충대사종합정진단표준재뇌졸중고위인군중적응용.방법 선택뇌졸중고위환자,비교3충표준적진단차이,병비교불동진단표준하유무대사종합정(MS)여경동맥죽양경화적관계.결과 응용IDF、NECP-ATPⅢ수정판화“혈지지남”표준,MS환병솔분별위61.7％、72.4％화58.9％;MS조경동맥내중막증후(54.3％대50.3％、55.0％대46.8％、57.0％대46.6％,균P＜0.05)급반괴(44.9％대38.7％、45.2％대35.7％、47.8％대35.0％、균P＜0.05)적검출솔균현저고우비MS조;수착MS조분수적증가,경동맥내중막증후급반괴검출솔축점증가(균P＜0.01);3충진단표준적MS사경동맥죽양경화적풍험균증강.결론 MS능증가경동맥죽양경화환병솔,재예측경동맥내중막증후시이NECP-ATPⅢ수정판표준돌출,이예측경동맥반괴시이“혈지지남”표준돌출.
Objective To compare 3 types of diagnostic criteria for metabolic syndrome (MS) in patients with high risk of stroke.Three types of criteria were proposed by (1) International Diabetes Federation (IDF),(2) The revised National Cholesterol Education Program-Adult Treatment Panel Ⅲ (NCEP-ATP Ⅲ-R),and (3) " Guideline of Dyslipidemia Control for Chinese Adult" (" Guideline").Methods A total 4 206 patients with high risk of stroke were enrolled in the study.Diagnosis of MS was made according to three different criteria,and carotid atherosclerosis was evaluated in the patients with or without MS.Results The prevalences of MS according to the IDF,NCEP-ATP Ⅲ-R,and " Guideline" were 61.7％,72.4％,and 58.9％ respectively.The incidence of thickened carotid intimamedia(54.3％ vs 50.3％,55.0％ vs 46.8％,57.0％ vs 46.6％,all P＜0.05) and carotid atherosclerotic plaques (44.9％ vs 38.7％,45.2％ vs 35.7％,47.8％ vs 35.0％,all P＜0.05) was significantly higher in MS patients than non-MS ones.As the number of MS components increased,the incidence of carotid atherosclerosis rised significantly (all P＜0.01).Conclusions MS is related to raised incidence of carotid atherosclerosis.NCEP-ATP Ⅲ-R seems more suitable in detecting thickened carotid intima-media layer.While " Guideline" is better in predicting carotid atherosclerotic plaques.
