中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2014年
3期
221-224
,共4页
刘佳%徐援%高霞%姚志%张鹏睿%王广
劉佳%徐援%高霞%姚誌%張鵬睿%王廣
류가%서원%고하%요지%장붕예%왕엄
甲状腺球蛋白%自身免疫性甲状腺疾病%基因多态性
甲狀腺毬蛋白%自身免疫性甲狀腺疾病%基因多態性
갑상선구단백%자신면역성갑상선질병%기인다태성
Thyroglobulin%Autoimmune thyroid disease%Gene polymorphism
采用meta分析系统评价甲状腺球蛋白基因多态性与自身免疫性甲状腺疾病(AITD)易感性的关系.共纳入8项病例对照研究,E33SNP及E12SNP与亚洲人AITD的OR分别为1.54(95％ CI 1.21～1.97,P=0.024)及1.12(95％ CI 1.05～ 1.21,P=0.033).甲状腺球蛋白基因多态性与AITD可能相关.
採用meta分析繫統評價甲狀腺毬蛋白基因多態性與自身免疫性甲狀腺疾病(AITD)易感性的關繫.共納入8項病例對照研究,E33SNP及E12SNP與亞洲人AITD的OR分彆為1.54(95％ CI 1.21～1.97,P=0.024)及1.12(95％ CI 1.05～ 1.21,P=0.033).甲狀腺毬蛋白基因多態性與AITD可能相關.
채용meta분석계통평개갑상선구단백기인다태성여자신면역성갑상선질병(AITD)역감성적관계.공납입8항병례대조연구,E33SNP급E12SNP여아주인AITD적OR분별위1.54(95％ CI 1.21～1.97,P=0.024)급1.12(95％ CI 1.05～ 1.21,P=0.033).갑상선구단백기인다태성여AITD가능상관.
The association between thyroglobulin gene polymorphism and autoimmune thyroid disease was investigated.A total of eight case-control studies were included.E33SNP was associated with increased susceptibility of autoimmune thyroid disease in recessive model (OR =1.54,95 ％ CI 1.21 ～ 1.97,P =0.024),while E12SNP was associated with increased susceptibility of autoimmune thyroid disease in allele model (OR =1.12,95％ CI 1.05 ～1.21,P =0.033).Thyroglobulin gene polymorphism seems to be associated with autoimmune thyroid disease.
