CAJ | 학술논문

临床试验及流行病学资料的meta分析显示胆固醇代谢、血清胆固醇水平及胆固醇合成抑制剂(他汀)与结直肠癌的关系密切.本文将就胆固醇代谢与结直肠癌发生的关系及其在分子病理学及遗传药理学方面的机制作一综述.
림상시험급류행병학자료적meta분석현시담고순대사、혈청담고순수평급담고순합성억제제(타정)여결직장암적관계밀절.본문장취담고순대사여결직장암발생적관계급기재분자병이학급유전약이학방면적궤제작일종술.
Recent meta-analysis based on both clinical trials and epidemiological studies has revealed the relationship of dietary cholesterol,blood cholesterol level and cholesterol lowering drugs (statins) with colorectal cancer.This review summarises the advances in current evidences of linking cholesterol metabolism and risk of colorectal cancer and the underlying molecular mechanisms based on pharmacogenetics and molecular pathology.