CAJ | 학술논문

真核细胞通过调节细胞内蛋白质的降解和细胞器的更新来维持内稳态.自噬是一种类泛素化的降解过程,在维持细胞生存、分化和胞内物质清理方面发挥重要作用.之前关于自噬的研究主要集中在肿瘤、神经变性疾病等方面,自噬与能量代谢的研究很少.2009年开始陆续有关于自噬调节代谢方面的研究,本文综述了最新的关于自噬与脂肪细胞分化、自噬与脂滴的储存与分解的研究进展.
진핵세포통과조절세포내단백질적강해화세포기적경신래유지내은태.자서시일충류범소화적강해과정,재유지세포생존、분화화포내물질청리방면발휘중요작용.지전관우자서적연구주요집중재종류、신경변성질병등방면,자서여능량대사적연구흔소.2009년개시륙속유관우자서조절대사방면적연구,본문종술료최신적관우자서여지방세포분화、자서여지적적저존여분해적연구진전.
Eukaryotic cells maintain cellular homeostasis by regulating the process of protein degradation and organelle turnover.Autophagy is a ubiquitin-like degradation process,and plays an essential role in cellular development,differentiation,and elimination of damaged organelles and protein.Previous studies mostly focused autophagy on tumor and neurodegenerative diseases,whereas studies about autophagy and energy remain not clear.Since 2009,an increasing number of studies have showed light on the importance of autophagy in regulating lipid metabolism.The review focuses on the relationship between autophagy and differentiation of adipocytes,lipogenesis,and lipolysis.