CAJ | 학술논문

不论是1型还是2型糖尿病,其中都有显著的β细胞量的损失,了解β细胞量在糖尿病病程中的变化对于糖尿病的诊断及治疗将提供重要的信息.以核磁共振显像、正电子发射断层显像(PET)等为代表的功能显像方法因其具有实用性、非创伤性以及安全性等特点,在β细胞量检测中存在潜在的应用价值.其中,放射性核素标记的影像技术是针对人体β细胞最敏感的显像方法,在针对β细胞量的dihydrotetrabenazine PET显像上,已取得了初步研究结果.对于导致2型糖尿病的关键因素,18F-6-葡萄糖(18F-6-deoxy-6-fluoro-D-glucose,18F-6-FDG)已被证明是活体研究葡萄糖转运状态的有效示踪剂,因而其在反应胰岛素抵抗状态中具有潜在研究价值.进一步发展糖尿病的功能影像学诊断研究对于明确糖尿病的发病机制、建立客观的早期诊断方法以及评估各类治疗方法的有效性具有潜在巨大的应用价值.
불론시1형환시2형당뇨병,기중도유현저적β세포량적손실,료해β세포량재당뇨병병정중적변화대우당뇨병적진단급치료장제공중요적신식.이핵자공진현상、정전자발사단층현상(PET)등위대표적공능현상방법인기구유실용성、비창상성이급안전성등특점,재β세포량검측중존재잠재적응용개치.기중,방사성핵소표기적영상기술시침대인체β세포최민감적현상방법,재침대β세포량적dihydrotetrabenazine PET현상상,이취득료초보연구결과.대우도치2형당뇨병적관건인소,18F-6-포도당(18F-6-deoxy-6-fluoro-D-glucose,18F-6-FDG)이피증명시활체연구포도당전운상태적유효시종제,인이기재반응이도소저항상태중구유잠재연구개치.진일보발전당뇨병적공능영상학진단연구대우명학당뇨병적발병궤제、건립객관적조기진단방법이급평고각류치료방법적유효성구유잠재거대적응용개치.
In either type 1 or type 2 diabetes,there is significant loss of β cell mass.Understanding the changing of β cell mass in the course of diabetes would provide important information for diagnosis and treatment.Functional imaging like magnetic resonance imaging or positron emission tomography (PET) can provide safe and noninvasive detection of loss of β cell mass in the course of diabetes.Among them,radio-labelled imaging is the most sensitive imaging procedure of the β cell ; For dihydrotetrabenazine PET imaging aiming β cell mass,there has been some primary outcome.For the key factor causing type 2 diabetes,18 F-6-deoxy-6-fluoro-D-glucose (18F-6-FDG) PET imaging is an effective tracer to study the glucose transporting condition in vivo.Further development of functional imaging will be of great value in diagnosis and treatment of diabetes.