CAJ | 학술논문

出生后早期是生长发育的关键期,如营养过度会导致成年期持续性和永久性的体重过重/肥胖和胰岛素抵抗等代谢综合征表现,胰岛素作用的重要靶器官如肝脏、脂肪组织、骨骼肌和中枢神经系统均可出现胰岛素抵抗.涉及的主要机制包括胰岛素信号通路异常、游离脂肪酸和部分脂肪因子分泌增加、氧化应激、摄食/厌食神经调节失衡、下丘脑-垂体-肾上腺轴/糖皮质激素调节失常以及表观遗传的作用等.建议出生后早期避免营养过度,以减少成年期胰岛素抵抗发生的危险.
출생후조기시생장발육적관건기,여영양과도회도치성년기지속성화영구성적체중과중/비반화이도소저항등대사종합정표현,이도소작용적중요파기관여간장、지방조직、골격기화중추신경계통균가출현이도소저항.섭급적주요궤제포괄이도소신호통로이상、유리지방산화부분지방인자분비증가、양화응격、섭식/염식신경조절실형、하구뇌-수체-신상선축/당피질격소조절실상이급표관유전적작용등.건의출생후조기피면영양과도,이감소성년기이도소저항발생적위험.
Overnutrition during the early postnatal life,a critical time window for growth and development,may induce metabolic syndrome later in life,including overweight/obesity and insulin resistance.The important target organs of insulin,such as liver,adipose tissue,skeletal muscle,and central nervous systems show insulin resistance.The involved mechanisms include abnormality of insulin signal pathway,increment of free fatty acid and some adipocytokines,oxidative stress,maladjustment of orexigenic and anorexigenic neuron,modifications of the hypothalamic-pituitary-adrenal glucocorticoid axis as well as epigenetic,etc.Hence,overnutrition should be avoided during the early postnatal life,so as to decrease the risk of developing long-term insulin resistance.