CAJ | 학술논문

分析无锡地区50岁以上居民肥胖及相关衡量指标与胰岛素抵抗关系的特点以5 316名无锡地区50岁及以上的常住居民为研究对象,记录性别、年龄及一般情况,测量身高、体重、腰围及臀围等,并检测相关代谢指标.该人群肥胖患病率为11.95％,其中中心性肥胖率占57.24％,男性均小于女性(P＜0.05);随着体重指数及腰围的增加,胰岛素抵抗发生率逐步增加(P＜0.05);同时随着稳态模型评估的胰岛素抵抗指数(HOMA-IR)增加,肥胖率及中心性肥胖率(P＜0.05);体重指数、腰围及腰臀比对胰岛素抵抗均有一定的预测价值,并且男性腰围切点为87.5 cm,女性腰围切点为84 cm;相同体重指数水平人群中,中心性肥胖组的代谢指标大多高于对照组,且在体重指数正常组中代谢指标的升高有统计学意义(P＜0.05);体重正常代谢性肥胖组的代谢指标大多高于代谢正常性肥胖组,其中以空腹血糖、胰岛素、HOMA-IR差异有统计学意义无锡市50岁以上人群中肥胖(尤其是中心性肥胖)与胰岛素抵抗密切相关,同时腰围能够及时有效地预测胰岛素抵抗,预防代谢综合征和心血管疾病的发生.
분석무석지구50세이상거민비반급상관형량지표여이도소저항관계적특점이5 316명무석지구50세급이상적상주거민위연구대상,기록성별、년령급일반정황,측량신고、체중、요위급둔위등,병검측상관대사지표.해인군비반환병솔위11.95％,기중중심성비반솔점57.24％,남성균소우녀성(P＜0.05);수착체중지수급요위적증가,이도소저항발생솔축보증가(P＜0.05);동시수착은태모형평고적이도소저항지수(HOMA-IR)증가,비반솔급중심성비반솔(P＜0.05);체중지수、요위급요둔비대이도소저항균유일정적예측개치,병차남성요위절점위87.5 cm,녀성요위절점위84 cm;상동체중지수수평인군중,중심성비반조적대사지표대다고우대조조,차재체중지수정상조중대사지표적승고유통계학의의(P＜0.05);체중정상대사성비반조적대사지표대다고우대사정상성비반조,기중이공복혈당、이도소、HOMA-IR차이유통계학의의 무석시50세이상인군중비반(우기시중심성비반)여이도소저항밀절상관,동시요위능구급시유효지예측이도소저항,예방대사종합정화심혈관질병적발생.
To analyze the relationship between obesity with related measurable indicators and insulin resistance among the residents over 50-year-old in Wuxi area.The questionnaire survey,physical examination,and relevant biochemical measurements as well as gender,age,height,body w eight,waist circumference,and hip circumference were obtained.The prevalence of obesity was 11.95％ of which 57.24％ were with central obesity,and the prevalence in male was higher than that in female(P＜0.05).With inereasing body mass index (BMI) and waist circumference(WC),the prevalence of insulin resistance increased gradually (P ＜ 0.05).Meanwhile,With the increasing HOMA-IR,the prevalence of obesity and central obesity also gradually increased (P＜0.05).BMI,WC,and waist-to-hip ratio can effectively predict insulin resistance.The cut-off point of waist circumference was 87.5 cm for male,and 84 cm for female.At the same level of body mass index,metabolic measurements in central obesity group were higher than those of non-central obesity group with the same body mass index,especially in normal weight group.The related metabolic measurements of metabolic obesity but normal weight group were mostly higher than metabolically healthy but obese group,and there were statistically significant differences in fasting blood glucose,fasting insulin,HOMA-IR and HOMA-β.Obesity,especially central obesity,is closely related to insulin resistance among residents over 50-year-old in Wuxi area.Meanwhile,waist circumference may effectively predict insulin resistance and may serve as a parameter in the occurrence of metabolic syndrome and cardiovascular diseases.