CAJ | 학술논문

4周龄雄性SD大鼠经高脂喂养8周后予小剂量链脲佐菌素腹腔注射以建立糖尿病模型,分为糖尿病组和瘤坏死因子相关的凋亡诱导配体(tumor necrosis factor-related apoptosis ligand,TRAIL)干预组,另选正常SD大鼠为对照组.TRAIL干预3个月.与糖尿病组相比,TRAIL干预组总胆固醇、甘油三酯、血糖、胰岛素显著降低,大鼠主动脉粥样斑块病变面积及光镜下内膜厚度减小[(23.8±5.7)％对(47.6±7.8)％].提示TRAIL可减轻糖尿病大鼠动脉粥样硬化病变.
4주령웅성SD대서경고지위양8주후여소제량련뇨좌균소복강주사이건립당뇨병모형,분위당뇨병조화류배사인자상관적조망유도배체(tumor necrosis factor-related apoptosis ligand,TRAIL)간예조,령선정상SD대서위대조조.TRAIL간예3개월.여당뇨병조상비,TRAIL간예조총담고순、감유삼지、혈당、이도소현저강저,대서주동맥죽양반괴병변면적급광경하내막후도감소[(23.8±5.7)％대(47.6±7.8)％].제시TRAIL가감경당뇨병대서동맥죽양경화병변.
Four-week-old male Sprague-Dawley rats were rendered diabetic by intraperitoneal injection of streptozotocin (STZ) after feeding high-fat-diet for 8 weeks,and divided into diabetes group and tumor necrosis factorrelated apoptosis ligand(TRAIL) group.Normal rats severed as a control group.Treatment with TRAIL lasted for 3 months.Total cholesterol,triglycerides,low-density lipoprotein-cholesterol,blood glucose,and insulin levels were decreased in TRAIL group,as compared with diabetes group.Area of atherosclerotic lesion in TRAIL group [(23.8 ± 5.7) ％] was significantly smaller than that in diabetes group [(47.6 ± 7.8) ％].It suggested that TRAIL may reduce the area of atherosclerotic lesion in diabetic rats.