CAJ | 학술논문

目的探讨生活方式干预对成年糖耐量受损患者血糖的影响.方法检索MEDLINE(Pub Med)、EMBASE、Science Citation Index (SCI)及Cochrane数据库获取相关文献.以葡萄糖负荷后2h、空腹血糖水平为结局指标.仅限于英文文献.按照纳入和排除标准选择相关研究进行文献质量评价后,以标准化均数差(SMD)表示效应的差异,使用Stata 11.0进行meta分析.结果共有10篇研究被纳入meta分析.生活方式干预对负荷后2h血糖和空腹血糖影响均有统计学意义(SMD:-0.67,P＜0.01;SMD:-0.33,P＜0.01),但均存在高异质性.结论运动锻炼、饮食调节等生活方式干预可能降低糖耐量受损患者的血糖水平.由于研究间的异质性较大,生活方式干预对血糖水平的影响仍需要更多高质量的RCTs研究.
목적 탐토생활방식간예대성년당내량수손환자혈당적영향.방법 검색MEDLINE(Pub Med)、EMBASE、Science Citation Index (SCI)급Cochrane수거고획취상관문헌.이포도당부하후2h、공복혈당수평위결국지표.부한우영문문헌.안조납입화배제표준선택상관연구진행문헌질량평개후,이표준화균수차(SMD)표시효응적차이,사용Stata 11.0진행meta분석.결과 공유10편연구피납입meta분석.생활방식간예대부하후2h혈당화공복혈당영향균유통계학의의(SMD:-0.67,P＜0.01;SMD:-0.33,P＜0.01),단균존재고이질성.결론 운동단련、음식조절등생활방식간예가능강저당내량수손환자적혈당수평.유우연구간적이질성교대,생활방식간예대혈당수평적영향잉수요경다고질량적RCTs연구.
Objective To determine the efficacy of lifestyle interventions in adults with impaired glucose tolerance (IGT).Methods MEDLINE (Pub Med),EMBASE,Science Citation Index (SCI),and Cochrane Database were retrieved for articles about the relations of lifestyle intervention and IGT.Searches were limited to English language publications.The RCTs outcome evaluated in this study included 2 h plasma glucose level and fasting plasma glucose,meta-analysis was carried oat by Stata 11.0 among articles for the inclusion and exclusion criteria.The difference of effects was expressed as standardized mean deviation(SMD).Results A total of 10 RCTs studies met the inclusion criteria.Lifestyle interventions were associated with a decline in 2 h plasma glucose and fasting plasma glucose level (SMD =-0.67,P＜0.01 ;SMD =-0.33,P＜0.01),but high heterogeneity was identified in this meta-analysis.Conclusion Physical,dietary and both combined interventions can reduce 2-h plasma glucose and fasting plasma glucose levels in adults with impaired glucose tolerance.As high heterogeneity was identified in this meta-analysis,more high quality research is needed.