CAJ | 학술논문

目的评估SUSPPUP指数(血钠与尿钠的比值除以血钾平方与尿钾的比值)在原发性醛固酮增多症(PA)筛查中的作用.方法对952例高血压患者进行坐位血浆肾素活性(PRA)及醛固酮浓度(PAC)的检测,根据PA初筛标准及盐水负荷试验标准,筛查出PA组204例和排除PA的原发性高血压组261例,比较两组尿钾/尿钠、SUSPPUP指数和PAC/PRA比值(ARR)等指标的差异.构建和比较尿钾/尿钠、SUSPPUP指数和ARR对诊断PA的ROC曲线.结果 SUSPPUP曲线下面积0.797,与ARR曲线下面积相当(0.796).SUSPPUP的最佳切点为1.0,敏感性和特异性分别达到98.9％和81％.结论 SUSPPUP可以作为快速筛查PA一个价格不高的指标.
목적 평고SUSPPUP지수(혈납여뇨납적비치제이혈갑평방여뇨갑적비치)재원발성철고동증다증(PA)사사중적작용.방법 대952례고혈압환자진행좌위혈장신소활성(PRA)급철고동농도(PAC)적검측,근거PA초사표준급염수부하시험표준,사사출PA조204례화배제PA적원발성고혈압조261례,비교량조뇨갑/뇨납、SUSPPUP지수화PAC/PRA비치(ARR)등지표적차이.구건화비교뇨갑/뇨납、SUSPPUP지수화ARR대진단PA적ROC곡선.결과 SUSPPUP곡선하면적0.797,여ARR곡선하면적상당(0.796).SUSPPUP적최가절점위1.0,민감성화특이성분별체도98.9％화81％.결론 SUSPPUP가이작위쾌속사사PA일개개격불고적지표.
Objective To assess the effectiveness of the quotient of serum sodium to urinary sodium divided by (serum potassium) 2 to urinary potassium (SUSPPUP) in screening for primary aldosteronism (PA).Methods Among 952 patients with hypertension who had renin activity,aldosterone measurements and concomitant serum and urinary biochemistry data,204 patients were diagnosed as cases of PA and 261 as cases of essential hypertension.Diagnosis of PA was made in accordance with established laboratory criteria including renin activity and aldosterone,plasma aldosterone concentration/plasma renin activity (ARR),and saline loading test.The SUSPPUP ratio with the ARR were compared in two groups.Results The area under the curve of SUSPPUP and ARR was 0.797 and 0.796 respectively according to receiver operating characteristic curve,optimal cutoff of SUSPPUP was 1.0,the sensitivity and specificity of SUSPPUP was 98.9％ and 81％ respectively.Conclusions The SUSPPUP ratio is an inexpensive and rapid tool to assess the extent of mineralocorticoid excess,therefore,SUSPPUP ratio can be applied to screen PA in hypertensive patients.