CAJ | 학술논문

目的研究血糖标准差(SD)在不同糖耐量人群动态血糖监测中的意义.方法本研究共纳入220名研究对象,其中47名正常糖耐量(NGR),52例糖耐量受损(IGT,20例为单纯糖耐量受损,32例IGT伴空腹血糖受损),61例单纯2h血糖确诊的糖尿病(DM2h),60例空腹和2h血糖均确诊的完全糖尿病.所有受试者均进行连续72 h动态血糖监测,并计算血糖波动参数,包括血糖标准差(SD)、连续每隔1h血糖净作用(CONGA1)、平均血糖绝对差(MODD)、平均血糖波动幅度(MAGE).围绕平均血糖的SD被认为是评估血糖波动的经典有效指标,分析各组MAGE、MODD、CONGA1和SD的相关性.结果血糖波动指标SD、CONGA1、MODD和MAGE从NGR、IGT、DM2h至完全糖尿病组逐渐升高(P＜0.05).但MAGE/SD、MODD/SD和CONGA1/SD在NGR、IGT、DM2h和完全糖尿病组具有可比性(P值分别为0.988、0.320和0.350).在总体上,MAGE/SD、MODD/SD和CONGA1/SD的值分别为2.24±0.43、0.94±0.17和0.89±0.24.结论在NGR、IGT、DM2h和完全糖尿病组,或者总体上,MAGE、MODD、CONGA1和SD的比值呈线性比例关系,根据SD可以初步推算MAGE、MODD、CONGA1.
목적 연구혈당표준차(SD)재불동당내량인군동태혈당감측중적의의.방법 본연구공납입220명연구대상,기중47명정상당내량(NGR),52례당내량수손(IGT,20례위단순당내량수손,32례IGT반공복혈당수손),61례단순2h혈당학진적당뇨병(DM2h),60례공복화2h혈당균학진적완전당뇨병.소유수시자균진행련속72 h동태혈당감측,병계산혈당파동삼수,포괄혈당표준차(SD)、련속매격1h혈당정작용(CONGA1)、평균혈당절대차(MODD)、평균혈당파동폭도(MAGE).위요평균혈당적SD피인위시평고혈당파동적경전유효지표,분석각조MAGE、MODD、CONGA1화SD적상관성.결과 혈당파동지표SD、CONGA1、MODD화MAGE종NGR、IGT、DM2h지완전당뇨병조축점승고(P＜0.05).단MAGE/SD、MODD/SD화CONGA1/SD재NGR、IGT、DM2h화완전당뇨병조구유가비성(P치분별위0.988、0.320화0.350).재총체상,MAGE/SD、MODD/SD화CONGA1/SD적치분별위2.24±0.43、0.94±0.17화0.89±0.24.결론 재NGR、IGT、DM2h화완전당뇨병조,혹자총체상,MAGE、MODD、CONGA1화SD적비치정선성비례관계,근거SD가이초보추산MAGE、MODD、CONGA1.
Objective To investigate the significance of standard deviation of blood glucose in the continuous glucose monitoring of the subjects across a range of glucose tolerance from normal to overt type 2 diabetes.Methods Totally 220 subjects were recruited in the study,including 47 with normal glucose regulation (NGR),52 with impaired glucose tolerance (IGT,20 with isolated impaired glucose tolerance,and 32 with IGT and impaired fasting glucose),61 with diabetes diagnosed by isolated 2 h plasma glucose (DM2h),and 60 newly diagnosed diabetes by both fasting and 2 h plasma glucose (DM).All subjects were monitored by using the continuous glucose monitoring system for consecutive 72 hours.The multiple parameters of glycemic variability included the standard deviation of blood glucose (SD),continuous overlapping net glycemic action calculated every 1 h (CONGA1),mean of daily differences(MODD),and mean amplitude of glycemic excursions (MAGE).Results Glycemic variability parameters,including SD,CONGA1,MODD,and MAGE,all increased from NGR to IGT,DM2h,DM group (P＜0.05).However,MAGE/SD,MODD/SD,and CONGA1/SD were comparable in the NGR,IGT,DM2h,and DM groups(P=0.988,0.320,and 0.350,respectively).The ratios of MAGE,MODD,and CONGA1 to SD in the entire data set were 2.24 ± 0.43,0.94 ± 0.17,and 0.89 ± 0.24,respectively.Conclusions There were direct linear proportionalities between MAGE,MODD,CONGA1,and SD for each glucose tolerance group or the entire data set.MAGE,MODD,and CONGA1 can be calculated according to SD.