CAJ | 학술논문

按严格纳入及排除标准选取185例门诊及住院2型糖尿病患者,包括男性组(n=95)与绝经后女性组(n=90),搜集血清骨钙素及空腹血糖、HbA1C、空腹胰岛素、空腹C肽、稳态模型评估的胰岛素抵抗指数(HOMA-IR)、稳态模型评估的胰岛β细胞功能(HOMA-β)、血脂、体重指数、腰臀比等相关指标,进行Pearson相关性分析及多元逐步回归分析,探讨骨钙素与各糖脂代谢指标之间的关系.结果显示,骨钙素与HbA1C呈明显负相关(P＜0.05),而且骨钙素是影响HbA1C水平的独立相关因素.表明骨钙素可能参与2型糖尿病患者糖代谢的调节.
안엄격납입급배제표준선취185례문진급주원2형당뇨병환자,포괄남성조(n=95)여절경후녀성조(n=90),수집혈청골개소급공복혈당、HbA1C、공복이도소、공복C태、은태모형평고적이도소저항지수(HOMA-IR)、은태모형평고적이도β세포공능(HOMA-β)、혈지、체중지수、요둔비등상관지표,진행Pearson상관성분석급다원축보회귀분석,탐토골개소여각당지대사지표지간적관계.결과현시,골개소여HbA1C정명현부상관(P＜0.05),이차골개소시영향HbA1C수평적독립상관인소.표명골개소가능삼여2형당뇨병환자당대사적조절.
A total of 185 patients with type 2 diabetes mellitus (T2DM) were consisted of male group (n =95) and postmenopausal female group (n =90).The parameters of fasting plasma glucose,HbA1c,fasting insulin,fasting C peptide,homeostasis model assessment insulin resistant index (HOMA-IR) and β-cell function (HOMA-β),blood lipid,body mass index,and waist to hip ratio were collected and analyzed by Pearson correlation analysis and stepwise multiple regression analysis.The relationships between osteocalcin and these parameters were investigated.The results revealed that osteocalcin was negatively correlated with HbA1C (P＜0.05),and osteocalcin was an independent relevant factor affecting HbA1Clevels.Osteocalcin may be involved in the regulation of glucose metabolism in T2DM.