CAJ | 학술논문

为探讨中性粒细胞与淋巴细胞比值(NLR)与2型糖尿病微血管病变的相关性,将303例本院2型糖尿病患者根据有无微血管病变分为无微血管病变(N)组、单纯糖尿病肾病(DN)组、单纯视网膜病变(DR)组和糖尿病肾病合并视网膜病变(DNR)组.收集患者的一般临床指标及生化指标,分析NLR在各组之间的差异.结果显示,DN组、DR组、DNR组NLR、白细胞计数、中性粒细胞计数显著高于N组,且DNR组NLR高于DN组、DR组(3.35±1.35对2.05±0.68和1.89 ±0.60,均P＜0.05);DNR组淋巴细胞计数低于N组、DN组及DR组(P＜0.05).以有无微血管病变为因变量,患者一般临床指标及生化指标为自变量进行多因素logistic回归分析,显示NLR是2型糖尿病患者微血管病变的危险因素(OR=6.643,95％CI3.502～ 12.601,P＜0.01).
위탐토중성립세포여림파세포비치(NLR)여2형당뇨병미혈관병변적상관성,장303례본원2형당뇨병환자근거유무미혈관병변분위무미혈관병변(N)조、단순당뇨병신병(DN)조、단순시망막병변(DR)조화당뇨병신병합병시망막병변(DNR)조.수집환자적일반림상지표급생화지표,분석NLR재각조지간적차이.결과현시,DN조、DR조、DNR조NLR、백세포계수、중성립세포계수현저고우N조,차DNR조NLR고우DN조、DR조(3.35±1.35대2.05±0.68화1.89 ±0.60,균P＜0.05);DNR조림파세포계수저우N조、DN조급DR조(P＜0.05).이유무미혈관병변위인변량,환자일반림상지표급생화지표위자변량진행다인소logistic회귀분석,현시NLR시2형당뇨병환자미혈관병변적위험인소(OR=6.643,95％CI3.502～ 12.601,P＜0.01).
To explore the relationship between neutrophil-lymphocyte ratio (NLR) and microangiopathy in type 2 diabetes mellitus,303 type 2 diabetic patients were divided into non-microangiopathy (N),diabetic nephropathy (DN),diabetic retinopathy (DR),and DN combined with DR (DNR) groups.The clinical and biochemical data were collected for comparing the differences in NLR among four groups.The results showed that NLR,white blood cell count,neutrophil count in DN,DR,and DNR groups were significantly higher than that in N group,and NLR in DNR group was higher than those in DN and DR groups (3.35 ± 1.35 vs 2.05 ± 0.68 and 1.89 ±0.60,both P＜ 0.05).However,the lymphocyte count in DNR was lower than that in other three groups.The multifactor logistic regression analysis showed that NLR was a risk factor for predicting microangiopathy in type 2 diabetic patients(OR=6.643,95％ CI3.502-12.601,P＜0.01).