CAJ | 학술논문

微小RNA (miRNAs)是一类内源性的非编码小RNA分子,在转录后水平通过影响靶mRNA的稳定性或翻译过程而负性调节靶基因的表达.近年来,研究表明miRNAs在甲状腺功能亢进(甲亢)性心脏病中对相关基因表达的调节起到重要作用.高甲状腺激素可通过肾素-血管紧张素(RAS)系统影响心血管系统,血管紧张素Ⅱ1型受体(AT1R)作为RAS系统中的主要活性成分,与miRNAs相互作用促进或延缓甲亢性心脏病的进展.现就miR-21、miR-155、miR-208a/b和miR-499等与AT1R相关的miRNAs在甲亢性心脏病中的作用作一综述.
미소RNA (miRNAs)시일류내원성적비편마소RNA분자,재전록후수평통과영향파mRNA적은정성혹번역과정이부성조절파기인적표체.근년래,연구표명miRNAs재갑상선공능항진(갑항)성심장병중대상관기인표체적조절기도중요작용.고갑상선격소가통과신소-혈관긴장소(RAS)계통영향심혈관계통,혈관긴장소Ⅱ1형수체(AT1R)작위RAS계통중적주요활성성분,여miRNAs상호작용촉진혹연완갑항성심장병적진전.현취miR-21、miR-155、miR-208a/b화miR-499등여AT1R상관적miRNAs재갑항성심장병중적작용작일종술.
MicroRNAs (miRNAs) are small endogenous non-coding RNA molecules.They regulate negatively the expression of target genes at post-transcriptional stages by means of affecting the stability of target mRNA or interfering with the transcriptional process.Recently,there is evidence demonstrating that miRNAs play important roles in the gene expressions of thyrotoxic heart diseases.Elevated levels of thyroid hormones profoundly influence the cardiovascular system through the renin-angiotensin system (RAS).As a principal active component of RAS,angiotensin Ⅱ receptor 1 (AT1 R) interacts with miRNAs in promoting or extenuating the progress of thyrotoxic heart disease.In this article,the roles of AT1R-associated miRNAs,miR-21,miR-155,miR-208a/b,and miR-499 in thyrotoxic heart disease were reviewed.