CAJ | 학술논문

目的探讨血清尿酸与代谢综合征(MS)及其组分的相关关系.方法 2009年10月至2010年2月采用分层整群抽样方法调查贵阳市城区宅吉社区20岁及以上常住居民共1 512人(男性634人,女性878人),详细填写流行病学调查问卷,口服75 g葡萄糖耐量试验,测量身高、体重、腰围及血压,采集静脉血样测定尿酸、空腹血糖、餐后2h血糖、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和空腹胰岛素.结果 (1)年龄、体重指数(BMI)、腰围、TG、TC、收缩压、舒张压水平和稳态模型评估的胰岛素抵抗指数(HOMA-IR)随尿酸分组的增高而增高(P＜0.05);(2)尿酸水平与MS的患病风险呈正相关(P＜0.05),经过年龄、性别、BMI、腰臀比和HOMA-IR校正后,尿酸最高四分位数的人群比最低四分位数人群的MS患病风险增加(OR=2.86,95％ CI 1.70 ～ 4.84,P＜0.05),这种相关性在女性人群中更明显(OR=2.80,95％ CI1.51 ～5.17,P＜0.05);(3)经过年龄、性别、BMI、腰臀比和HOMA-IR校正后,尿酸与腰围(OR=1.76,95％ CI0.95 ～ 3.27,P＜0.05)、血压(OR=1.66,95％ CI1.13 ～2.43,P＜0.05)和TG(OR=2.80,95％ CI 1.97 ～ 3.96,P＜0.05)呈正相关.结论 MS患病率随着尿酸增高而升高,尿酸升高可能是MS的独立危险因素.
목적 탐토혈청뇨산여대사종합정(MS)급기조분적상관관계.방법 2009년10월지2010년2월채용분층정군추양방법조사귀양시성구택길사구20세급이상상주거민공1 512인(남성634인,녀성878인),상세전사류행병학조사문권,구복75 g포도당내량시험,측량신고、체중、요위급혈압,채집정맥혈양측정뇨산、공복혈당、찬후2h혈당、감유삼지(TG)、총담고순(TC)、고밀도지단백담고순、저밀도지단백담고순화공복이도소.결과 (1)년령、체중지수(BMI)、요위、TG、TC、수축압、서장압수평화은태모형평고적이도소저항지수(HOMA-IR)수뇨산분조적증고이증고(P＜0.05);(2)뇨산수평여MS적환병풍험정정상관(P＜0.05),경과년령、성별、BMI、요둔비화HOMA-IR교정후,뇨산최고사분위수적인군비최저사분위수인군적MS환병풍험증가(OR=2.86,95％ CI 1.70 ～ 4.84,P＜0.05),저충상관성재녀성인군중경명현(OR=2.80,95％ CI1.51 ～5.17,P＜0.05);(3)경과년령、성별、BMI、요둔비화HOMA-IR교정후,뇨산여요위(OR=1.76,95％ CI0.95 ～ 3.27,P＜0.05)、혈압(OR=1.66,95％ CI1.13 ～2.43,P＜0.05)화TG(OR=2.80,95％ CI 1.97 ～ 3.96,P＜0.05)정정상관.결론 MS환병솔수착뇨산증고이승고,뇨산승고가능시MS적독립위험인소.
Objective To explore the association of serum uric acid (UA) with metabolic syndrome (MS) and its components.Methods A total of 1 512 inhabitants aged 20 years old and above in Zhaiji community of Guiyang urban areas were investigated from November 2009 to February 2010 by adopting stratified cluster sampling method (634 males and 878 females).All subjects were asked to fulfill the questionnaires and to measure the height,weight,waist circumstance (WC),and blood pressure ; and to undertake oral glucose tolerance test.Venous blood samples were drawn to measure UA,fasting plasma glucose,2 h postprandial plasma glucose,triglyceride (TG),total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol,and fasting insulin.Results (1) Age,body mass index (BMI),WC,TG,and blood pressure,and homeostasis model assessment of insulin resistance (HOMA-IR) increased with UA (all P＜0.05).(2) UA was positively associated with the risk of MS (P＜ 0.05).After adjusting for age,sex,BMI,waist-to-hip ratio (WHR),and HOMA-IR,the risk of MS in individuals with the highest uric acid quartiles was significantly increased compared to those with the lowest quartile (OR =2.86,95 ％ CI 1.70-4.84,P＜0.05),and this finding was especially evident in females (OR=2.80,95％ CI 1.51-5.17,P＜0.05).(3) UA was strongly related to WC (OR =1.76,95％ CI0.95-3.27,P＜0.05),blood pressure (OR =1.66,95 ％ CI 1.13-2.43,P＜0.05),and TG (OR =2.80,95％ CI 1.97-3.96,P＜0.05) after adjustment for age,sex,BMI,WHR,and HOMA-IR.Conclusion The prevalence of MS increased with UA.Higher UA level may be an independent risk factor for MS.