CAJ | 학술논문

目的研究载脂蛋白B/A-Ⅰ(Apolipoprotein B/A-Ⅰ,ApoB/A-Ⅰ)与非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的相关性.方法在上海市嘉定区40岁以上居民中进行问卷调查、体格检查、生化检测及高分辨率超声检查,对其中数据完整的2 139名受试者进行分析.采用多元logistic回归模型分析ApoB/A-Ⅰ与NAFLD患病风险之间的关系.结果从ApoB/A-Ⅰ第一分位组到第四分位组,NAFLD患病率逐渐升高,分别为14.3％、23.6％、30.4％、40.4％(组间趋势P＜0.01).多元logistic回归分析显示,校正年龄、性别、目前吸烟及主要代谢指标后,ApoB/A-Ⅰ每增加1,NAFLD患病风险增加105％(OR=2.05,95％ CI 1.19 ～3.53,P=0.01).结论载脂蛋白B/A-Ⅰ与非酒精性脂肪性肝病患病风险的增加存在独立正相关性.
목적 연구재지단백B/A-Ⅰ(Apolipoprotein B/A-Ⅰ,ApoB/A-Ⅰ)여비주정성지방성간병(non-alcoholic fatty liver disease,NAFLD)적상관성.방법 재상해시가정구40세이상거민중진행문권조사、체격검사、생화검측급고분변솔초성검사,대기중수거완정적2 139명수시자진행분석.채용다원logistic회귀모형분석ApoB/A-Ⅰ여NAFLD환병풍험지간적관계.결과 종ApoB/A-Ⅰ제일분위조도제사분위조,NAFLD환병솔축점승고,분별위14.3％、23.6％、30.4％、40.4％(조간추세P＜0.01).다원logistic회귀분석현시,교정년령、성별、목전흡연급주요대사지표후,ApoB/A-Ⅰ매증가1,NAFLD환병풍험증가105％(OR=2.05,95％ CI 1.19 ～3.53,P=0.01).결론 재지단백B/A-Ⅰ여비주정성지방성간병환병풍험적증가존재독립정상관성.
Objective To study the association between apolipoprotein B/A-Ⅰ(ApoB/A-Ⅰ) and the risk of prevalence of non-alcoholic fatty liver disease (NAFLD).Methods This is a community-based cross-sectional analysis conducted among 2 519 residents aged 40 years or older from Jiading District,Shanghai,China.All subjects underwent a standard questionnaire,anthropometric measurements,and biochemical evaluation.Non-alcoholic fatty liver disease was defined by hepatic ultrasonography.After excluding subjects with excess alcohol consumption and medical history of liver diseases,more than three times of normal serum alanine aminotransferase (ALT),aspartate aminotransferase(AST),and γ-glutamyltransferase (GGT) levels were obtained in 2 139 subjects.Unadjusted and multivariate adjusted logistic regression analyses were applied to estimate the association between ApoB/A-Ⅰ ratio and the risk of prevalent NAFLD.Results Increased ApoB/A-Ⅰ ratio was associated with a less favorable metabolic profile.The prevalence of NAFLD increased in accordance with the quartiles of ApoB/A-Ⅰ ratio(14.3％,23.6％,30.4％,40.4％,respectively,P＜0.01).In the multivariate adjusted logistic regression analysis,the risk of having NAFLD increased by 105％ with each unit increment in ApoB/A-Ⅰ ratio (OR =2.05,95％ CI 1.19-3.53,P =0.01).Conclusions ApoB/A-Ⅰ ratio is associated with the risk of prevalent NAFLD,being independent of other established metabolic risk factors.