中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2014年
10期
839-843
,共5页
简咏梅%李传荣%袁俊清%孙永宁
簡詠梅%李傳榮%袁俊清%孫永寧
간영매%리전영%원준청%손영저
糖尿病%胃癌%易患性%队列研究%Meta分析
糖尿病%胃癌%易患性%隊列研究%Meta分析
당뇨병%위암%역환성%대렬연구%Meta분석
Diabetes mellitus%Gastric cancers%Susceptibility%Cohort studies%Meta-analysis
通过检索PubMed、Embase、Cochrane Library和ISI Web of knowledge数据库,收集糖尿病患者胃癌发生风险的队列研究,同时检索所有纳入文献的参考文献,没有语言和出版日期的限制.采用纽卡斯尔-渥太华(Newcastle-Ottawa)质量评价量表对文献进行质量评价.并对研究对象的性别、地域、不同糖尿病类型、糖尿病病程及对照组来源进行亚组分析,所有的统计学处理均使用Stata 12.0软件.25篇队列研究符合我们的入选标准,经异质性检验使用随机效应模型合并效应量RR及其95％ CI,得糖尿病与胃癌相关(RR=1.20,95％ CI1.12～1.28),亚组分析显示该结果在男性(RR=1.15,95％ CI 1.02 ～ 1.29)、女性(RR=1.29,95％ CI 1.09 ～ 1.53)及1型(RR=2.20,95％ CI 1.45 ～3.35)、2型(RR=1.20,95％ CI 1.12～1.31)糖尿病患者中均具有统计学意义.与非糖尿病患者相比,糖尿病会增加胃癌的发生率约20％,可能是胃癌的危险因素之一,该趋势在1型糖尿病及女性患者中更显著.
通過檢索PubMed、Embase、Cochrane Library和ISI Web of knowledge數據庫,收集糖尿病患者胃癌髮生風險的隊列研究,同時檢索所有納入文獻的參攷文獻,沒有語言和齣版日期的限製.採用紐卡斯爾-渥太華(Newcastle-Ottawa)質量評價量錶對文獻進行質量評價.併對研究對象的性彆、地域、不同糖尿病類型、糖尿病病程及對照組來源進行亞組分析,所有的統計學處理均使用Stata 12.0軟件.25篇隊列研究符閤我們的入選標準,經異質性檢驗使用隨機效應模型閤併效應量RR及其95％ CI,得糖尿病與胃癌相關(RR=1.20,95％ CI1.12～1.28),亞組分析顯示該結果在男性(RR=1.15,95％ CI 1.02 ～ 1.29)、女性(RR=1.29,95％ CI 1.09 ～ 1.53)及1型(RR=2.20,95％ CI 1.45 ～3.35)、2型(RR=1.20,95％ CI 1.12～1.31)糖尿病患者中均具有統計學意義.與非糖尿病患者相比,糖尿病會增加胃癌的髮生率約20％,可能是胃癌的危險因素之一,該趨勢在1型糖尿病及女性患者中更顯著.
통과검색PubMed、Embase、Cochrane Library화ISI Web of knowledge수거고,수집당뇨병환자위암발생풍험적대렬연구,동시검색소유납입문헌적삼고문헌,몰유어언화출판일기적한제.채용뉴잡사이-악태화(Newcastle-Ottawa)질량평개량표대문헌진행질량평개.병대연구대상적성별、지역、불동당뇨병류형、당뇨병병정급대조조래원진행아조분석,소유적통계학처리균사용Stata 12.0연건.25편대렬연구부합아문적입선표준,경이질성검험사용수궤효응모형합병효응량RR급기95％ CI,득당뇨병여위암상관(RR=1.20,95％ CI1.12～1.28),아조분석현시해결과재남성(RR=1.15,95％ CI 1.02 ～ 1.29)、녀성(RR=1.29,95％ CI 1.09 ～ 1.53)급1형(RR=2.20,95％ CI 1.45 ～3.35)、2형(RR=1.20,95％ CI 1.12～1.31)당뇨병환자중균구유통계학의의.여비당뇨병환자상비,당뇨병회증가위암적발생솔약20％,가능시위암적위험인소지일,해추세재1형당뇨병급녀성환자중경현저.
PubMed,Embase,Cochrane Library,and ISI web were searched without any limitations with regard to publication date or language,as well as the references of qualifying articles.All kinds of cohort studies comprising the risk of gastric cancer between diabetic patients and control subjects were included.We excluded studies that investigated only mortality but not incidence.25 studies met our criteria,and the qualities of these studies were evaluated using the Newcastle-Ottawa Quality Assessment Scale.Statistical analyses were carried out with STATA software version 12.0.A random-effects model meta-analysis showed an increased risk of gastric cancer in diabetic patients (RR =1.20,95 ％ CI 1.12-1.28).Subgroup analyses indicated that this result persisted in studies of both male(RR =1.15,95％ CI 1.02-1.29) and female (RR =1.29,95％ CI 1.09-1.53) subjects,in studies of European countries(RR =1.25,95％ CI 1.07-1.46) and Asia countries (RR =1.18,95％ CI 1.09-1.28).Compared with nondiabetics,the incidence of gastric cancer may be increased by approximately 20％ in diabetics.Thus diabetes may be an independent risk factor for gastric cancer.This effect tends to be more significant in type 1 and female patients.
