中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2012年
10期
777-780
,共4页
李涛%王华丽%杨渊韩%James E. Galvin%John C. Morris%于欣
李濤%王華麗%楊淵韓%James E. Galvin%John C. Morris%于訢
리도%왕화려%양연한%James E. Galvin%John C. Morris%우흔
阿尔茨海默病%认知障碍%《AD8》
阿爾茨海默病%認知障礙%《AD8》
아이자해묵병%인지장애%《AD8》
Alzheimer disease%Cognition disorder%《AD8》
目的 检验《AD8》中文译本在Alzheimer病(AD)患者中应用的信度与效度;初步确定《AD8》中文译本区分AD患者与认知正常老人界限分值及敏感度和特异度.方法 共入组240例受试者,正常对照75例,AD患者165例.正常对照和AD患者接受临床痴呆量表(CDR)、简易精神状态检查(MMSE)、画钟测验(CDT)评估.向所有正常对照及AD患者知情者询问《AD8》中文译本.其中158例AD患者知情者在1个月内重测《AD8》.结果 (1)《AD8》中文译本的克朗巴赫系数α=0.78,重测信度(ICC)=0.96(P＜0.01).(2)各条目评分间相关系数为0.36～0.69(P＜0.01);《AD8》中文译本总分与CDR总体评分(r=0.82,P＜0.01)和各领域评分总和(r=0.80,P＜0.01)呈正相关,与MMSE(r=-0.75,P＜0.01)和CDT得分(r=-0.53,P＜0.01)呈负相关.(3)《AD8》鉴别认知正常者与AD患者的AUC=0.93,以≥2为认知损害的界限分值,敏感度为93.9％,特异度为76.0％.结论 《AD8》中文译本具有良好的信度和效度,是识别早期痴呆的一项简单敏感的筛查工具.
目的 檢驗《AD8》中文譯本在Alzheimer病(AD)患者中應用的信度與效度;初步確定《AD8》中文譯本區分AD患者與認知正常老人界限分值及敏感度和特異度.方法 共入組240例受試者,正常對照75例,AD患者165例.正常對照和AD患者接受臨床癡呆量錶(CDR)、簡易精神狀態檢查(MMSE)、畫鐘測驗(CDT)評估.嚮所有正常對照及AD患者知情者詢問《AD8》中文譯本.其中158例AD患者知情者在1箇月內重測《AD8》.結果 (1)《AD8》中文譯本的剋朗巴赫繫數α=0.78,重測信度(ICC)=0.96(P＜0.01).(2)各條目評分間相關繫數為0.36～0.69(P＜0.01);《AD8》中文譯本總分與CDR總體評分(r=0.82,P＜0.01)和各領域評分總和(r=0.80,P＜0.01)呈正相關,與MMSE(r=-0.75,P＜0.01)和CDT得分(r=-0.53,P＜0.01)呈負相關.(3)《AD8》鑒彆認知正常者與AD患者的AUC=0.93,以≥2為認知損害的界限分值,敏感度為93.9％,特異度為76.0％.結論 《AD8》中文譯本具有良好的信度和效度,是識彆早期癡呆的一項簡單敏感的篩查工具.
목적 검험《AD8》중문역본재Alzheimer병(AD)환자중응용적신도여효도;초보학정《AD8》중문역본구분AD환자여인지정상노인계한분치급민감도화특이도.방법 공입조240례수시자,정상대조75례,AD환자165례.정상대조화AD환자접수림상치태량표(CDR)、간역정신상태검사(MMSE)、화종측험(CDT)평고.향소유정상대조급AD환자지정자순문《AD8》중문역본.기중158례AD환자지정자재1개월내중측《AD8》.결과 (1)《AD8》중문역본적극랑파혁계수α=0.78,중측신도(ICC)=0.96(P＜0.01).(2)각조목평분간상관계수위0.36～0.69(P＜0.01);《AD8》중문역본총분여CDR총체평분(r=0.82,P＜0.01)화각영역평분총화(r=0.80,P＜0.01)정정상관,여MMSE(r=-0.75,P＜0.01)화CDT득분(r=-0.53,P＜0.01)정부상관.(3)《AD8》감별인지정상자여AD환자적AUC=0.93,이≥2위인지손해적계한분치,민감도위93.9％,특이도위76.0％.결론 《AD8》중문역본구유량호적신도화효도,시식별조기치태적일항간단민감적사사공구.
Objective To examine the validity and reliability of the application of Chinese version of AD8 among patients with Alzheimer's disease (AD),and to explore the discriminative properties of AD8 including score boundaries,sensitivity and specificity in differentiating AD and normal controls.Methods A total of 240 subjects were recruited,including 75 cognitively intact subjects as normal control and 165patients with AD.Normal control and patients with AD were assessed with Clinical Dementia Rating (CDR),Mini-Mental State Examination (MMSE),and Clock Drawing Test (CDT).All informed normal controls and informants of patients with AD were asked about Chinese version of AD8,among which,158informants of patients with AD received AD8 examination again.Results (1) The Cronbach alpha for Chinese version of AD8 was 0.78.The intraclass correlation coefficient (ICC) of retest reliability was 0.96(P ＜ 0.01).(2) The correlation coefficients between each item of AD8 ranged from 0.36 to 0.69(P＜ 0.01).Chinese version of AD8 total scores were strongly positively correlated with CDR global score (r =0.82,P ＜ 0.01),and CDR-SB(r =0.80,P ＜ 0.01),and negatively correlated with the total score of MMSE (r =-0.75,P ＜0.01)and CDT(r =-0.53,P ＜0.01).(3) For discrimination between normal controls and patients with AD,the AUC was 0.93.Using a cutoff of 2 or greater on Chinese version of AD8 to discriminate dementia,the sensitivity was 93.9％,and specificity was 76.0％.Conclusion Chinese version of AD8 is a brief and sensitive screening measure with good validity and reliability.
