中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
1期
22-24
,共3页
刘岸新%刘晓明%李蔚然%刘凤珍
劉岸新%劉曉明%李蔚然%劉鳳珍
류안신%류효명%리위연%류봉진
心脏手术%体外循环%羟乙基淀粉%琥珀酰明胶
心髒手術%體外循環%羥乙基澱粉%琥珀酰明膠
심장수술%체외순배%간을기정분%호박선명효
Cardiac surgery%Extracorporeal circulation%Hydroxyethyl starch%Succinylated gelatin
目的 比较新一代中分子羟乙基淀粉与琥珀酰明胶用于体外循环心脏手术时对机体的影响,探讨二药在心血管手术中容量治疗的有效性和安全性.方法 选择54例行瓣膜置换术的患者,完全随机分为羟乙基淀粉组和琥珀酰明胶组,各27例.羟乙基淀粉组在体外循环前、体外循环中及术后住ICU期间应用羟乙基淀粉作为体外循环预充液和补充血容量的血浆代用品；琥珀酰明胶组同期应用琥珀酰明胶作为体外循环预充液和补充血容量的血浆代用品.观察并比较2组患者围术期生命体征、血浆胶体渗透压、液体出入量.结果 2组患者均痊愈出院.2组患者各时间血压差异均无统计学意义(P＞0.05).羟乙基淀粉组诱导后、术毕、ICU 2 h、ICU 6 h和ICU 20 h的胶体渗透压分别为(19.2±2.0)、(19.3±4.6)、(17.0±2.1)、(20.7±2.2)、(20.5 ±2.2)mm Hg,琥珀酰明胶组分别为(18.1±2.3)、(16.9±2.0)、(16.9±2.3)、(19.3±4.5) 、(20.0 ±2.1)mm Hg,2组差异无统计学意义.结论 羟乙基淀粉与琥珀酰明胶可安全用于心脏直视手术围术期的容量治疗.
目的 比較新一代中分子羥乙基澱粉與琥珀酰明膠用于體外循環心髒手術時對機體的影響,探討二藥在心血管手術中容量治療的有效性和安全性.方法 選擇54例行瓣膜置換術的患者,完全隨機分為羥乙基澱粉組和琥珀酰明膠組,各27例.羥乙基澱粉組在體外循環前、體外循環中及術後住ICU期間應用羥乙基澱粉作為體外循環預充液和補充血容量的血漿代用品；琥珀酰明膠組同期應用琥珀酰明膠作為體外循環預充液和補充血容量的血漿代用品.觀察併比較2組患者圍術期生命體徵、血漿膠體滲透壓、液體齣入量.結果 2組患者均痊愈齣院.2組患者各時間血壓差異均無統計學意義(P＞0.05).羥乙基澱粉組誘導後、術畢、ICU 2 h、ICU 6 h和ICU 20 h的膠體滲透壓分彆為(19.2±2.0)、(19.3±4.6)、(17.0±2.1)、(20.7±2.2)、(20.5 ±2.2)mm Hg,琥珀酰明膠組分彆為(18.1±2.3)、(16.9±2.0)、(16.9±2.3)、(19.3±4.5) 、(20.0 ±2.1)mm Hg,2組差異無統計學意義.結論 羥乙基澱粉與琥珀酰明膠可安全用于心髒直視手術圍術期的容量治療.
목적 비교신일대중분자간을기정분여호박선명효용우체외순배심장수술시대궤체적영향,탐토이약재심혈관수술중용량치료적유효성화안전성.방법 선택54례행판막치환술적환자,완전수궤분위간을기정분조화호박선명효조,각27례.간을기정분조재체외순배전、체외순배중급술후주ICU기간응용간을기정분작위체외순배예충액화보충혈용량적혈장대용품；호박선명효조동기응용호박선명효작위체외순배예충액화보충혈용량적혈장대용품.관찰병비교2조환자위술기생명체정、혈장효체삼투압、액체출입량.결과 2조환자균전유출원.2조환자각시간혈압차이균무통계학의의(P＞0.05).간을기정분조유도후、술필、ICU 2 h、ICU 6 h화ICU 20 h적효체삼투압분별위(19.2±2.0)、(19.3±4.6)、(17.0±2.1)、(20.7±2.2)、(20.5 ±2.2)mm Hg,호박선명효조분별위(18.1±2.3)、(16.9±2.0)、(16.9±2.3)、(19.3±4.5) 、(20.0 ±2.1)mm Hg,2조차이무통계학의의.결론 간을기정분여호박선명효가안전용우심장직시수술위술기적용량치료.
Objective To compare the clinical effects of a new generation of 6％ hydroxyethyl starch 130/0.4 and 4％ succinylated gelatin on patients in cardiac surgery with cardiopulmonary bypass (CPB),and to further explore the effectiveness and security of both plasma substitutes during cardiovascular surgery.Methods Fifty-four patients of valve replacement surgery were randomly divided into two groups.In one group (n =27),the 6％ hydroxyethyl starch 130/0.4 was applied as the primary plasma substitutes to supply the blood volume during the cardiovascular surgery.The patients of the other group (n =27),as the control,were applied the 4％ succinylated gelatin as the priming solution and plasma substitutes in perioperative period.The normal vital signs of patients were analyzed in perioperative period.Plasma marker of patients,fluid intake and output were also detected in perioperative period.Results All patients were recovered.There were no significant differences in the normal vital signs of patients between two groups (P ＞ 0.05).Plasma colloid osmotic pressure of patients and fluid intake and output were also no significantly different between two groups.Conclusions There are no differences in 6％ hydroxyethyl starch 130/0.4 and 4％ succinylated gelatin during cardiac surgery.Both plasma substitutes can be used in heart surgery safely and effectively.
