CAJ | 학술논문

目的观察开郁合剂治疗抑郁症的临床疗效.方法对30例抑郁症患者给予开郁合剂进行治疗,分别于治疗前及治疗2、4、6周末采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评定药物的疗效.结果抑郁症患者口服开郁合剂2、4、6周末HAMD评分和HAMA评分均明显低于治疗前[HAMD评分:(10.8±2.4)、(9.0±1.9)、(7.4±1.4)分比(12.6±2.9)分；HAMA评分:(9.9±2.6)、(8.1±1.7)、(6.7±0.9)分比(11.9±3.2)分；均P＜0.05],且HAMD评分和HAMA评分的降低呈时间依赖性；2、4、6周末间两两比较,差异均有统计学意义(P＜0.05).治疗4、6周末,总有效率分别为23.3％(7/30)、93.3％ (28/30),差异有统计学意义(P＜0.05).在治疗期间未出现任何不良反应.结论开郁合剂治疗抑郁症疗效显著,临床使用安全.
목적 관찰개욱합제치료억욱증적림상료효.방법 대30례억욱증환자급여개욱합제진행치료,분별우치료전급치료2、4、6주말채용한밀이돈억욱량표(HAMD)、한밀이돈초필량표(HAMA)평정약물적료효.결과 억욱증환자구복개욱합제2、4、6주말HAMD평분화HAMA평분균명현저우치료전[HAMD평분:(10.8±2.4)、(9.0±1.9)、(7.4±1.4)분비(12.6±2.9)분；HAMA평분:(9.9±2.6)、(8.1±1.7)、(6.7±0.9)분비(11.9±3.2)분；균P＜0.05],차HAMD평분화HAMA평분적강저정시간의뢰성；2、4、6주말간량량비교,차이균유통계학의의(P＜0.05).치료4、6주말,총유효솔분별위23.3％(7/30)、93.3％ (28/30),차이유통계학의의(P＜0.05).재치료기간미출현임하불량반응.결론 개욱합제치료억욱증료효현저,림상사용안전.
Objective To observe the clinical efficacy of the Kaiyu mixture treating depression.Methods All 30 cases of patients with depression were treated with Kaiyu mixture.Hamilton rating scale (HAMD) and Hamilton anxiety scale (HAMA) were used to evaluate the therapeutic efficacy of Kaiyu mixture before and after drug administration.Results The scores of HAMD and HAMA in patients with depression were significantly decreased 2,4 and 6 weeks after oral administration of Kaiyu mixture compared with those before treatment [HAMD:(10.8 ±2.4),(9.0±1.9),(7.4± 1.4) scores vs (12.6 ±2.9)scores; HAMA:(9.9 ± 2.6),(8.1 ± 1.7),(6.7 ± 0.9) scores vs (11.9 ± 3.2) scores ; all P ＜ 0.05].The total effective rates after treatment for 2 weeks and 4 weeks were 23.3％ (7/30),93.3％ (28/30),and there was significant difference(P ＜0.05).No adverse reaction was found during the treatment of Kaiyu mixture.Conclusions Kaiyu mixture is safe and effective treating depression.