中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
1期
47-48
,共2页
胡玮%王峻%吕华荣%吴星%陈志功
鬍瑋%王峻%呂華榮%吳星%陳誌功
호위%왕준%려화영%오성%진지공
颅脑外伤%丙泊酚%靶控输注%S100B蛋白
顱腦外傷%丙泊酚%靶控輸註%S100B蛋白
로뇌외상%병박분%파공수주%S100B단백
Traumatic brain injury%Propofol%Target-controlled infusion%S100B protein
目的 研究丙泊酚对重型颅脑损伤患者血清S100B蛋白浓度的影响,评价丙泊酚脑保护作用.方法 40例重型颅脑损伤患者按就诊顺序随机分为常规治疗组、丙泊酚组,各20例.各组患者均行急诊开颅手术,常规治疗组在手术前后只给予各项常规治疗；丙泊酚组在常规治疗基础上,手术后当天开始靶控输注丙泊酚,先静脉注射丙泊酚1.5 mg/kg行镇静诱导,然后改用微量注射泵持续注射丙泊酚,根据不同镇静程度用药量为0.5～4.0 mg/(kg·h),应用丙泊酚时间至少到手术后第3天.分别测定2组入院时以及手术后第1、3、5、7天的血清S100B蛋白水平.结果 手术后丙泊酚组第1、3、5、7天血清S100B浓度分别为(3.19±0.25)、(2.48±0.23)、(2.22±0.27)、(2.00±0.21) μg/L,均低于常规治疗组[(3.23±0.20)、(2.89±0.28)、(2.55±0.26)、(2.30 ±0.20) μg/L](均P＜0.05).结论 丙泊酚静脉靶控输注能有效降低重型颅脑损伤血清S100B蛋白浓度,具有脑保护作用.
目的 研究丙泊酚對重型顱腦損傷患者血清S100B蛋白濃度的影響,評價丙泊酚腦保護作用.方法 40例重型顱腦損傷患者按就診順序隨機分為常規治療組、丙泊酚組,各20例.各組患者均行急診開顱手術,常規治療組在手術前後隻給予各項常規治療；丙泊酚組在常規治療基礎上,手術後噹天開始靶控輸註丙泊酚,先靜脈註射丙泊酚1.5 mg/kg行鎮靜誘導,然後改用微量註射泵持續註射丙泊酚,根據不同鎮靜程度用藥量為0.5～4.0 mg/(kg·h),應用丙泊酚時間至少到手術後第3天.分彆測定2組入院時以及手術後第1、3、5、7天的血清S100B蛋白水平.結果 手術後丙泊酚組第1、3、5、7天血清S100B濃度分彆為(3.19±0.25)、(2.48±0.23)、(2.22±0.27)、(2.00±0.21) μg/L,均低于常規治療組[(3.23±0.20)、(2.89±0.28)、(2.55±0.26)、(2.30 ±0.20) μg/L](均P＜0.05).結論 丙泊酚靜脈靶控輸註能有效降低重型顱腦損傷血清S100B蛋白濃度,具有腦保護作用.
목적 연구병박분대중형로뇌손상환자혈청S100B단백농도적영향,평개병박분뇌보호작용.방법 40례중형로뇌손상환자안취진순서수궤분위상규치료조、병박분조,각20례.각조환자균행급진개로수술,상규치료조재수술전후지급여각항상규치료；병박분조재상규치료기출상,수술후당천개시파공수주병박분,선정맥주사병박분1.5 mg/kg행진정유도,연후개용미량주사빙지속주사병박분,근거불동진정정도용약량위0.5～4.0 mg/(kg·h),응용병박분시간지소도수술후제3천.분별측정2조입원시이급수술후제1、3、5、7천적혈청S100B단백수평.결과 수술후병박분조제1、3、5、7천혈청S100B농도분별위(3.19±0.25)、(2.48±0.23)、(2.22±0.27)、(2.00±0.21) μg/L,균저우상규치료조[(3.23±0.20)、(2.89±0.28)、(2.55±0.26)、(2.30 ±0.20) μg/L](균P＜0.05).결론 병박분정맥파공수주능유효강저중형로뇌손상혈청S100B단백농도,구유뇌보호작용.
Objective To investigate the effect of target-controlled propofol on serum level of S100B protein in patients with severe head injury.Methods Forty patients with severe head injury were randomly divided into routine treatment group and propofo group with twenty cases in each group.All patients had the emergency craniotomy operation.The routine treatment group was only given routine therapy before and after operation,including sedation,dehydration,hemostatic,inflammatory,neurotrophy and supportive therapy; the propofol group was given the basis treatment plus the target-controlled propofol for at least three days after operation.The serum S100B levels were measured before operation,the 1 d,3 d,5 d,7 d after operation.Results The S100B levels in propofo group were significantly decreased in 1 d [(3.19 ±0.25)μg/L],3 d[(2.48 ±0.23)μg/L],5 d [(2.22 ± 0.27) μg/L] and 7 d [(2.00 ± 0.21) μg/L] after operation compared with routine treatment group [(3.23 ±0.20) μg/L,(2.89 ±0.28)μg/L,(2.55 ± 0.26) μg/L,(2.30±0.20)μg/L] (all P＜0.05).Conclusions Propofol of target controlled can effectively reduce the serum S100B levels in severe craniocerebral injury patients after the operation and protect neurocytes.
