中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
1期
83-85
,共3页
前列腺癌%良性前列腺增生%前列腺特异抗原%合并症
前列腺癌%良性前列腺增生%前列腺特異抗原%閤併癥
전렬선암%량성전렬선증생%전렬선특이항원%합병증
Prostate carcinoma%Benign prostatic hyperplasia%Prostate specific antigen%Complication
目的 探讨急性尿潴留、尿路感染、慢性前列腺炎等合并症对良性前列腺增生(BPH)患者前列腺特异性抗原(PSA)的影响,评价总PSA(TPSA)与游离PSA(FPSA)/TPSA在BPH和前列腺癌鉴别诊断中的应用价值.方法 对144例BPH以及前列腺癌患者进行PSA测定,其中前列腺癌组30例、BPH无合并症组43例、BPH有合并症组71例(合并急性尿潴留组23例、合并尿路感染组36例、合并慢性前列腺炎组12例),并对各组患者的血清TPSA及FPSA/TPSA比值的差异进行比较分析.结果 前列腺癌组血清TPSA[(61.1 ±29.3)μg/L]明显高于BPH无合并症组[(2.8 ±0.6)μg/L]和BPH有合并症组[合并急性尿潴留组(5.1±2.6)μg/L,合并尿路感染组(6.7±2.0) μg/L,合并慢性前列腺炎组(8.1±5.3) μg/L],差异均有统计学意义(均P ＜0.05),FPSA/TPSA比值[(0.14±0.02)μg/L]明显低于BPH无合并症组[(0.27±0.04) μg/L]和BPH有合并症组[合并急性尿潴留组(0.26±0.06) μg/L),合并尿路感染组(0.25±0.05) μg/L,合并慢性前列腺炎组(0.23 ±0.07) μg/L,差异均有统计学意义(均P＜0.01)；而有、无合并症的BPH各组之间上述指标差异均无统计学意义(均P＞0.05).结论 合并急性尿潴留、尿路感染、慢性前列腺炎的BPH患者的TPSA值比无合并症的BPH患者增高,但TPSA、FPSA/TPSA对BPH、前列腺癌仍有鉴别诊断价值.
目的 探討急性尿潴留、尿路感染、慢性前列腺炎等閤併癥對良性前列腺增生(BPH)患者前列腺特異性抗原(PSA)的影響,評價總PSA(TPSA)與遊離PSA(FPSA)/TPSA在BPH和前列腺癌鑒彆診斷中的應用價值.方法 對144例BPH以及前列腺癌患者進行PSA測定,其中前列腺癌組30例、BPH無閤併癥組43例、BPH有閤併癥組71例(閤併急性尿潴留組23例、閤併尿路感染組36例、閤併慢性前列腺炎組12例),併對各組患者的血清TPSA及FPSA/TPSA比值的差異進行比較分析.結果 前列腺癌組血清TPSA[(61.1 ±29.3)μg/L]明顯高于BPH無閤併癥組[(2.8 ±0.6)μg/L]和BPH有閤併癥組[閤併急性尿潴留組(5.1±2.6)μg/L,閤併尿路感染組(6.7±2.0) μg/L,閤併慢性前列腺炎組(8.1±5.3) μg/L],差異均有統計學意義(均P ＜0.05),FPSA/TPSA比值[(0.14±0.02)μg/L]明顯低于BPH無閤併癥組[(0.27±0.04) μg/L]和BPH有閤併癥組[閤併急性尿潴留組(0.26±0.06) μg/L),閤併尿路感染組(0.25±0.05) μg/L,閤併慢性前列腺炎組(0.23 ±0.07) μg/L,差異均有統計學意義(均P＜0.01)；而有、無閤併癥的BPH各組之間上述指標差異均無統計學意義(均P＞0.05).結論 閤併急性尿潴留、尿路感染、慢性前列腺炎的BPH患者的TPSA值比無閤併癥的BPH患者增高,但TPSA、FPSA/TPSA對BPH、前列腺癌仍有鑒彆診斷價值.
목적 탐토급성뇨저류、뇨로감염、만성전렬선염등합병증대량성전렬선증생(BPH)환자전렬선특이성항원(PSA)적영향,평개총PSA(TPSA)여유리PSA(FPSA)/TPSA재BPH화전렬선암감별진단중적응용개치.방법 대144례BPH이급전렬선암환자진행PSA측정,기중전렬선암조30례、BPH무합병증조43례、BPH유합병증조71례(합병급성뇨저류조23례、합병뇨로감염조36례、합병만성전렬선염조12례),병대각조환자적혈청TPSA급FPSA/TPSA비치적차이진행비교분석.결과 전렬선암조혈청TPSA[(61.1 ±29.3)μg/L]명현고우BPH무합병증조[(2.8 ±0.6)μg/L]화BPH유합병증조[합병급성뇨저류조(5.1±2.6)μg/L,합병뇨로감염조(6.7±2.0) μg/L,합병만성전렬선염조(8.1±5.3) μg/L],차이균유통계학의의(균P ＜0.05),FPSA/TPSA비치[(0.14±0.02)μg/L]명현저우BPH무합병증조[(0.27±0.04) μg/L]화BPH유합병증조[합병급성뇨저류조(0.26±0.06) μg/L),합병뇨로감염조(0.25±0.05) μg/L,합병만성전렬선염조(0.23 ±0.07) μg/L,차이균유통계학의의(균P＜0.01)；이유、무합병증적BPH각조지간상술지표차이균무통계학의의(균P＞0.05).결론 합병급성뇨저류、뇨로감염、만성전렬선염적BPH환자적TPSA치비무합병증적BPH환자증고,단TPSA、FPSA/TPSA대BPH、전렬선암잉유감별진단개치.
Objective To compare the difference of prostate specific antigen(PSA) in patients of benign prostate hyperplasia(BPH) with acute urinary retention (AUR) urinary infection (UI) or chronic prostatitis (CP) ; to evaluate the value of serum PSA (TPSA and FPSA/TPSA) for differential diagnosis between BPH and Prostate Carcinoma (PCa).Methods The levels of TPSA and FPSA/TPSA ratio were detected and compared in 144 cases of PCa(30 cases) and BPH(BPH without complication 43 cases BPH with AUR 23 cases BPH with UI 36 cases BPH with CP 12 cases).Results The mean levels of TPSA in the cases of PCa and BPH without complication and with complicationwere(61.1±29.3)μg/L,(2.8±0.6)μg/L,(5.1 ±2.6)μg/L,(6.7 ±2.0) μg/L,(8.1±5.3) μg/L respectively (P ＜ 0.05) ; there were significant differences in serum TPSA among different groups (P ＜0.05).However there were not differences in FPSA/TPSA ratio between BPH without complication (0.27 ± 0.04) μg/L and BPH with complication [AUR (0.26 ± 0.06) μg/L ; UI (0.25 ± 0.05) μg/L ; CP (0.23 ± 0.07) μg/L] (P ＞0.05),but the mean ratios of FPSA/TPSA in PCa [(0.14 ± 0.02) μg/L] were significantly lower than those in other groups (P ＜ 0.05).Conclusions The mean levels of TPSA in BPH with AUR,UI,CP are higher than those in BPH without complication.However the mean levels of TPSA and FPSA/TPSA ratio till have value of differential diagnosis.
