中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
2期
219-220
,共2页
张本山%李婉丽%郑敏翠%杨海霞%蒋小梅%吴攀
張本山%李婉麗%鄭敏翠%楊海霞%蔣小梅%吳攀
장본산%리완려%정민취%양해하%장소매%오반
白血病%无病生存%Logistic回归
白血病%無病生存%Logistic迴歸
백혈병%무병생존%Logistic회귀
leukemia%Long-term survivors%Logistic Regression
目的 调查无病生存白血病儿童生存质量及其相关因素.方法 选择无病生存白血病儿童113例为观察组,选同期门诊体检健康儿童113例为对照组.采用儿童生存质量测定表体系对2组儿童的生存质量进行调查,并采用多因素非条件性Logistic回归模式分析影响无病生存白血病儿童生存质量的相关因素.结果 无病生存白血病儿童在生理、情感、社交以及学校功能上均低于正常儿童,差异有统计学意义[生理功能:(69±13)分比(86±9)分,情感功能:(79±10)分比(86±7)分,社交功能:(76±10)分比(89±8)分,学校功能:(77±10)分比(88±8)分,均P＜0.01]；多因素分析显示经过放射治疗[比值比(OR)=3.456,95％置信区间(CI):0.853 ～9.234]、有中度以上疼痛(OR=3.212,95％ CI:0.345～8.234)、总住院时间＞3个月(OR=1.234,95％ CI:0.453～ 10.232)、疾病反复发作(OR=1.234,95％CI:0.456～11.232)是影响白血病儿童生存质量的危险因素.结论 无病生存白血病儿童生存质量较差,其中放射治疗、中度以上疼痛、住院时间、反复发作是导致患儿生存质量下降的相关因素.
目的 調查無病生存白血病兒童生存質量及其相關因素.方法 選擇無病生存白血病兒童113例為觀察組,選同期門診體檢健康兒童113例為對照組.採用兒童生存質量測定錶體繫對2組兒童的生存質量進行調查,併採用多因素非條件性Logistic迴歸模式分析影響無病生存白血病兒童生存質量的相關因素.結果 無病生存白血病兒童在生理、情感、社交以及學校功能上均低于正常兒童,差異有統計學意義[生理功能:(69±13)分比(86±9)分,情感功能:(79±10)分比(86±7)分,社交功能:(76±10)分比(89±8)分,學校功能:(77±10)分比(88±8)分,均P＜0.01]；多因素分析顯示經過放射治療[比值比(OR)=3.456,95％置信區間(CI):0.853 ～9.234]、有中度以上疼痛(OR=3.212,95％ CI:0.345～8.234)、總住院時間＞3箇月(OR=1.234,95％ CI:0.453～ 10.232)、疾病反複髮作(OR=1.234,95％CI:0.456～11.232)是影響白血病兒童生存質量的危險因素.結論 無病生存白血病兒童生存質量較差,其中放射治療、中度以上疼痛、住院時間、反複髮作是導緻患兒生存質量下降的相關因素.
목적 조사무병생존백혈병인동생존질량급기상관인소.방법 선택무병생존백혈병인동113례위관찰조,선동기문진체검건강인동113례위대조조.채용인동생존질량측정표체계대2조인동적생존질량진행조사,병채용다인소비조건성Logistic회귀모식분석영향무병생존백혈병인동생존질량적상관인소.결과 무병생존백혈병인동재생리、정감、사교이급학교공능상균저우정상인동,차이유통계학의의[생리공능:(69±13)분비(86±9)분,정감공능:(79±10)분비(86±7)분,사교공능:(76±10)분비(89±8)분,학교공능:(77±10)분비(88±8)분,균P＜0.01]；다인소분석현시경과방사치료[비치비(OR)=3.456,95％치신구간(CI):0.853 ～9.234]、유중도이상동통(OR=3.212,95％ CI:0.345～8.234)、총주원시간＞3개월(OR=1.234,95％ CI:0.453～ 10.232)、질병반복발작(OR=1.234,95％CI:0.456～11.232)시영향백혈병인동생존질량적위험인소.결론 무병생존백혈병인동생존질량교차,기중방사치료、중도이상동통、주원시간、반복발작시도치환인생존질량하강적상관인소.
Objective To Research the quality ot lite ot long-term survivors with leukemia and related factors.Methods All 113 children with leukemia who survived with disease-free were included in observation group; 113 cases of healthy children at the same term were included in control group.By using multi factors non conditional Logistic regression analysis,the related factors influencing life quality of children with leukemia were analyzed.Results The children's physiological function,emotional function,social function and the function of school in observation group were lower than those in the control group [physiological functions:(69 ± 13)scores vs (86 ±9) scores,emotional function:(79 ± 10) scores vs (86 ± 7) scores,social function:(76 ± 10) scores vs (89 ± 8) scores,school functions:(77 ± 10) scores vs (88 ± 8) scores,P ＜ 0.01],multivariate analysis showed that after radiotherapy (OR =3.456,95 ％ CI:0.853-9.234),more than moderate pain (OR =3.212,95 ％ CI:0.345-8.234),a total hospital stay of ＞ 3 months (OR =1.234,95％ CI:0.453-10.232),disease recurrent episodes(OR =1.234,95％ CI:0.456-11.232) were the influence factors of quality of life in children with leukemia.Conclusion Long-term survivors with leukemia have poor quality of life.Radiotherapy,pain,hospitalization time,repeated episodes are the associated factors with decreasing quality of life.
