中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
4期
454-455
,共2页
环磷腺苷葡胺%心律失常,缓慢性%心率
環燐腺苷葡胺%心律失常,緩慢性%心率
배린선감포알%심률실상,완만성%심솔
Meglumine adenosine cyclophosphate%Arrhythmia,slow%Heart rate
目的 观察环磷腺苷葡胺(MAC)治疗器质性心脏病缓慢性心力律失常的临床疗效.方法 在常规治疗的基础上,将46例缓慢性心律失常患者完全随机分为MAC组和对照组,各23例.对照组给予扩张血管、利尿、降低血压、改善心功能等常规治疗；MAC组在对照组治疗的基础上,加用MAC120 mg于250ml葡萄糖液体内静脉滴注,每日1次.2组均以14 d为1个疗程.观察2组治疗前后患者平均心率和临床症状改善情况,并评价疗效.结果 MAC组治疗后Holter心电图心率明显高于治疗前和对照组治疗后[(60±5)次/min比(52±3)次/min、(54±4)次/min],差异均有统计学意义(均P＜0.05)；MAC组治疗后临床总有效率明显高于对照组[87.0％ (20/23)比78.3％(18/23)],差异有统计学意义(P＜0.05).结论 MAC能增加器质性心脏病缓慢性心律失常患者的心率,可提高临床有效率,改善临床症状.
目的 觀察環燐腺苷葡胺(MAC)治療器質性心髒病緩慢性心力律失常的臨床療效.方法 在常規治療的基礎上,將46例緩慢性心律失常患者完全隨機分為MAC組和對照組,各23例.對照組給予擴張血管、利尿、降低血壓、改善心功能等常規治療；MAC組在對照組治療的基礎上,加用MAC120 mg于250ml葡萄糖液體內靜脈滴註,每日1次.2組均以14 d為1箇療程.觀察2組治療前後患者平均心率和臨床癥狀改善情況,併評價療效.結果 MAC組治療後Holter心電圖心率明顯高于治療前和對照組治療後[(60±5)次/min比(52±3)次/min、(54±4)次/min],差異均有統計學意義(均P＜0.05)；MAC組治療後臨床總有效率明顯高于對照組[87.0％ (20/23)比78.3％(18/23)],差異有統計學意義(P＜0.05).結論 MAC能增加器質性心髒病緩慢性心律失常患者的心率,可提高臨床有效率,改善臨床癥狀.
목적 관찰배린선감포알(MAC)치료기질성심장병완만성심력률실상적림상료효.방법 재상규치료적기출상,장46례완만성심률실상환자완전수궤분위MAC조화대조조,각23례.대조조급여확장혈관、이뇨、강저혈압、개선심공능등상규치료；MAC조재대조조치료적기출상,가용MAC120 mg우250ml포도당액체내정맥적주,매일1차.2조균이14 d위1개료정.관찰2조치료전후환자평균심솔화림상증상개선정황,병평개료효.결과 MAC조치료후Holter심전도심솔명현고우치료전화대조조치료후[(60±5)차/min비(52±3)차/min、(54±4)차/min],차이균유통계학의의(균P＜0.05)；MAC조치료후림상총유효솔명현고우대조조[87.0％ (20/23)비78.3％(18/23)],차이유통계학의의(P＜0.05).결론 MAC능증가기질성심장병완만성심률실상환자적심솔,가제고림상유효솔,개선림상증상.
Objective To observe the clinical effects of meglumine adenosine cyclophosphate (MAC) on slow arrhythmia heart disease.Methods All 46 patients with slow arrhythmia were randomly divided into the treatment group and the control group with 23 patients each.The patients in the control group underwent the basis of conventional treatment.In addition of the conventional therapy,the treatment group was additionally treated with 120 mg MAC in 250 ml liquid drops daily.14 days was a course of treatment.ECG and symptoms after the treatment were observed and compared.Results The heart rate after operation in treatment group was higher than that before treatment and that postoperation of control group [(60 ± 5) times per min vs (52 ± 3),(54 ± 4) times per min],and there was significant difference (all P ＜ 0.05).The total effective rate in the treatment group was higher than that in control group [87.0％ (20/23) vs 78.3 ％ (18/23),P ＜ 0.05].Conclusions MAC can not only increase the heart rate of patient with organic heart disease and decrease the slow arrhythmia.It also improves the clinical outcome and ameliorate the symptoms.
