中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
4期
521-522
,共2页
甲状腺乳头状癌%血管内皮生长因子A%p53
甲狀腺乳頭狀癌%血管內皮生長因子A%p53
갑상선유두상암%혈관내피생장인자A%p53
Thyroid papillary carcinoma%Vascular endothelial growth factor A%p53
目的 探讨血管内皮生长因子(VEGF)与p53肿瘤蛋白联合Ki-67在甲状腺乳头状癌等组织中的表达及临床意义.方法 选取2010年1月至2011年12月甲状腺乳头状癌标本36例为研究组,术前均无放射治疗及化学治疗史.取同期甲状腺乳头状癌癌旁组织36例为对照组.采用免疫组织化学染色(免疫组化)链霉素抗生物素蛋白-过氧化酶连接(S-P)法检测VEGF、p53、Ki-67表达.结果 研究组VEGF、p53、Ki-67的阳性表达率分别为80.6％ (29/36)、86.1％ (31/36)和52.8％ (19/36),对照组大鼠分别为8.3％ (3/36)、22.2％ (8/36)和5.6％ (2/36),研究组与对照组的差异均有统计学意义(VEGF:x2=38.02,p53:x2=29.59,Ki-67:x2=18.94,均P＜0.01).结论 VEGF、p53和Ki-67表达可作为甲状腺乳头状癌的协助诊断指标,对临床治疗和预后判断具有重要的指导意义.
目的 探討血管內皮生長因子(VEGF)與p53腫瘤蛋白聯閤Ki-67在甲狀腺乳頭狀癌等組織中的錶達及臨床意義.方法 選取2010年1月至2011年12月甲狀腺乳頭狀癌標本36例為研究組,術前均無放射治療及化學治療史.取同期甲狀腺乳頭狀癌癌徬組織36例為對照組.採用免疫組織化學染色(免疫組化)鏈黴素抗生物素蛋白-過氧化酶連接(S-P)法檢測VEGF、p53、Ki-67錶達.結果 研究組VEGF、p53、Ki-67的暘性錶達率分彆為80.6％ (29/36)、86.1％ (31/36)和52.8％ (19/36),對照組大鼠分彆為8.3％ (3/36)、22.2％ (8/36)和5.6％ (2/36),研究組與對照組的差異均有統計學意義(VEGF:x2=38.02,p53:x2=29.59,Ki-67:x2=18.94,均P＜0.01).結論 VEGF、p53和Ki-67錶達可作為甲狀腺乳頭狀癌的協助診斷指標,對臨床治療和預後判斷具有重要的指導意義.
목적 탐토혈관내피생장인자(VEGF)여p53종류단백연합Ki-67재갑상선유두상암등조직중적표체급림상의의.방법 선취2010년1월지2011년12월갑상선유두상암표본36례위연구조,술전균무방사치료급화학치료사.취동기갑상선유두상암암방조직36례위대조조.채용면역조직화학염색(면역조화)련매소항생물소단백-과양화매련접(S-P)법검측VEGF、p53、Ki-67표체.결과 연구조VEGF、p53、Ki-67적양성표체솔분별위80.6％ (29/36)、86.1％ (31/36)화52.8％ (19/36),대조조대서분별위8.3％ (3/36)、22.2％ (8/36)화5.6％ (2/36),연구조여대조조적차이균유통계학의의(VEGF:x2=38.02,p53:x2=29.59,Ki-67:x2=18.94,균P＜0.01).결론 VEGF、p53화Ki-67표체가작위갑상선유두상암적협조진단지표,대림상치료화예후판단구유중요적지도의의.
Objective To explore the expression of vascular endothelial growth factor(VEGF),p53 gene (p53) and Ki-67 antigen(Ki-67) and their clinical significance in thyroid papillary carcinoma.Methods Selected 36 cases of papillary thyroid carcinoma from January 2010 to December 2011 for the research group,preoperative radiotherapy and chemotherapy had no history of treatment.Take over the same period in papillary thyroid cancer cancer adjacent tissue of 36 cases for the control group.Immunohistochemical staining technique was used to determine the expression of VEGF,p53 and Ki-67 in 36 thyroid papillary carcinoma cases and 36 adjacent normal tissue cases.Results The positive rates of VEGF,p53 and Ki-67 in thyroid papillary carcinoma were 80.6％ (29/36),86.1％ (31/36) and 52.8％ (19/36),the positive rates of VEGF,p53 and Ki-67 in adjacent tissues of cancer were 8.3％ (3/36),22.2％ (8/36) and 5.6％ (2/36),respectively,which were specificity higher than those in the normal thyroid tissues(P ＜ 0.01).There was correlation between these expression existed in thyroid papillary carcinoma.Conclusion The expression of VEGF,p53 and Ki-67 can be diagnostic index of papillary thyroidcarcinoma that has significant guiding significance in clinical treatment and patients' prognosis.
