中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
4期
541-542
,共2页
造血干细胞移植%喹诺酮%细菌感染%嗜麦芽窄食单胞菌
造血榦細胞移植%喹諾酮%細菌感染%嗜麥芽窄食單胞菌
조혈간세포이식%규낙동%세균감염%기맥아착식단포균
Hematopoietic stem cell transplantation%Quinolones%Bacterial infections%Stenotrophomonas maltophilia
目的 探讨异基因造血干细胞移植(allo-HSCT)患者发生嗜麦芽窄食单胞菌(SMA)感染的临床特点及抗感染疗效,指导临床治疗.方法 回顾性分析北京军区总医院120例行allo-HSCT患者的临床资料,分析SMA病原学依据和抗SMA治疗效果.结果 120例患者的SMA感染率为6.7％ (8/120),血液占25.0％ (2/8),下呼吸道感染占75.0％ (6/8).SMA对美罗培南、亚胺培南等β内酰胺酶类药物的耐药率为100％；对头孢曲松、头孢他啶耐药例数均为7例,敏感例数均为1例；对莫西沙星和左氧氟沙星的敏感例数分别为7和6例.结论 SMA是allo-HSCT后感染的重要病原菌之一,对β内酰胺酶、头孢菌素类药物敏感率低,对喹诺酮类较为敏感,临床抗感染治疗中,应根据药物敏感试验结果合理选择抗感染药物.
目的 探討異基因造血榦細胞移植(allo-HSCT)患者髮生嗜麥芽窄食單胞菌(SMA)感染的臨床特點及抗感染療效,指導臨床治療.方法 迴顧性分析北京軍區總醫院120例行allo-HSCT患者的臨床資料,分析SMA病原學依據和抗SMA治療效果.結果 120例患者的SMA感染率為6.7％ (8/120),血液佔25.0％ (2/8),下呼吸道感染佔75.0％ (6/8).SMA對美囉培南、亞胺培南等β內酰胺酶類藥物的耐藥率為100％；對頭孢麯鬆、頭孢他啶耐藥例數均為7例,敏感例數均為1例；對莫西沙星和左氧氟沙星的敏感例數分彆為7和6例.結論 SMA是allo-HSCT後感染的重要病原菌之一,對β內酰胺酶、頭孢菌素類藥物敏感率低,對喹諾酮類較為敏感,臨床抗感染治療中,應根據藥物敏感試驗結果閤理選擇抗感染藥物.
목적 탐토이기인조혈간세포이식(allo-HSCT)환자발생기맥아착식단포균(SMA)감염적림상특점급항감염료효,지도림상치료.방법 회고성분석북경군구총의원120례행allo-HSCT환자적림상자료,분석SMA병원학의거화항SMA치료효과.결과 120례환자적SMA감염솔위6.7％ (8/120),혈액점25.0％ (2/8),하호흡도감염점75.0％ (6/8).SMA대미라배남、아알배남등β내선알매류약물적내약솔위100％；대두포곡송、두포타정내약례수균위7례,민감례수균위1례；대막서사성화좌양불사성적민감례수분별위7화6례.결론 SMA시allo-HSCT후감염적중요병원균지일,대β내선알매、두포균소류약물민감솔저,대규낙동류교위민감,림상항감염치료중,응근거약물민감시험결과합리선택항감염약물.
Objective To improve diagnosis and therapy with the stenotrophomonas maltohpilia (SMA) infection after allogeneic hematopoietic stem cell transplantation.Methods SMA etiological basis and anti-SMA therapeutic effect were analyzed through the retrospective study of the clinical data of 120 cases of allogeneic hematopoietic stem cell transplantation patients.Results A total of eight cases had stenotrophomonas maltohpilia infection (6.7％) which mainly occurred in the blood and lower respiratory tract,followed by sepsis in 6 patients (6/8) and 2 cases (2/8) of lung infection.SMA meropenem,imipenem and other β-lactamase enzymes drug resistance showed high resistance to ceftriaxone.Sensitive rate of moxifloxacin and levofloxacin was 87.5％ and 75.0％ respectively.Conclusions Application results show that SMA is the important pathogenic bacteria infection after allogeneic hematopoietic stem cell transplantation.SMA is more sensitive to quinolones and clinical anti-infective therapy; rational selection of antibiotics should be based on susceptibility test results.
