中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
4期
545-546
,共2页
喜炎平注射液%利巴韦林喷剂%疱疹性咽峡炎
喜炎平註射液%利巴韋林噴劑%皰疹性嚥峽炎
희염평주사액%리파위림분제%포진성인협염
Xiyanping injection%Ribavirin spray%Herpangina
目的 探讨喜炎平注射液联合利巴韦林喷剂治疗疱疹性咽峡炎的疗效.方法 将2009年11月至2012年4月住院确诊疱疹性咽峡炎的患儿246例完全随机分为观察组(126例)和对照组(120例).对照组给予利巴韦林10～ 15 mg/(kg·d)静脉滴注；观察组给予喜炎平注射液0.1～0.2 ml/(kg·d)静脉滴注,加用利巴韦林喷剂喷口腔.疗程5d.2组均给予退热等对症处理,合并细菌感染者加用口服头孢克肟颗粒2～3 mg/(kg·d).观察2组患儿退热时间和咽痛、流涎消失时间及疱疹消退时间,并采用2组样本均数比较的t检验进行分析比较.结果 观察组总有效率[96.8％ (122/126)]明显高于对照组[89.2％(107/120)],差异具有统计学意义(P＜0.05).观察组与对照组退热时间和咽痛、流涎消失时间及疱疹消退时间比较,差异均有统计学意义[(2.3±0.8)d比(4.0±1.0)d,(3.2±1.4)d比(4.4±1.3)d,(3.2±0.7)d比(5.0±0.6)d,均P＜0.05].结论 喜炎平注射液联合利巴韦林喷剂治疗疱疹性咽峡炎可缩短病程,提高总有效率,临床疗效显著.
目的 探討喜炎平註射液聯閤利巴韋林噴劑治療皰疹性嚥峽炎的療效.方法 將2009年11月至2012年4月住院確診皰疹性嚥峽炎的患兒246例完全隨機分為觀察組(126例)和對照組(120例).對照組給予利巴韋林10～ 15 mg/(kg·d)靜脈滴註；觀察組給予喜炎平註射液0.1～0.2 ml/(kg·d)靜脈滴註,加用利巴韋林噴劑噴口腔.療程5d.2組均給予退熱等對癥處理,閤併細菌感染者加用口服頭孢剋肟顆粒2～3 mg/(kg·d).觀察2組患兒退熱時間和嚥痛、流涎消失時間及皰疹消退時間,併採用2組樣本均數比較的t檢驗進行分析比較.結果 觀察組總有效率[96.8％ (122/126)]明顯高于對照組[89.2％(107/120)],差異具有統計學意義(P＜0.05).觀察組與對照組退熱時間和嚥痛、流涎消失時間及皰疹消退時間比較,差異均有統計學意義[(2.3±0.8)d比(4.0±1.0)d,(3.2±1.4)d比(4.4±1.3)d,(3.2±0.7)d比(5.0±0.6)d,均P＜0.05].結論 喜炎平註射液聯閤利巴韋林噴劑治療皰疹性嚥峽炎可縮短病程,提高總有效率,臨床療效顯著.
목적 탐토희염평주사액연합리파위림분제치료포진성인협염적료효.방법 장2009년11월지2012년4월주원학진포진성인협염적환인246례완전수궤분위관찰조(126례)화대조조(120례).대조조급여리파위림10～ 15 mg/(kg·d)정맥적주；관찰조급여희염평주사액0.1～0.2 ml/(kg·d)정맥적주,가용리파위림분제분구강.료정5d.2조균급여퇴열등대증처리,합병세균감염자가용구복두포극우과립2～3 mg/(kg·d).관찰2조환인퇴열시간화인통、류연소실시간급포진소퇴시간,병채용2조양본균수비교적t검험진행분석비교.결과 관찰조총유효솔[96.8％ (122/126)]명현고우대조조[89.2％(107/120)],차이구유통계학의의(P＜0.05).관찰조여대조조퇴열시간화인통、류연소실시간급포진소퇴시간비교,차이균유통계학의의[(2.3±0.8)d비(4.0±1.0)d,(3.2±1.4)d비(4.4±1.3)d,(3.2±0.7)d비(5.0±0.6)d,균P＜0.05].결론 희염평주사액연합리파위림분제치료포진성인협염가축단병정,제고총유효솔,림상료효현저.
Objective To investigate the clinical efficacy of Xiyanping injection combined with ribavirin spray on herpangina.Methods Two hundred and forty-six children with herpangina admitted to Zhengzhou second people's hospital from Nov.2009 to Apr.2012 were reviewed.All 246 cases of children with herpangina were randomly divided into two groups.The patients in control group were treated with ribavirin [10-15 mg/(kg · d)] by intravenous drip,and the patients in observation groups were treated with xiyanping injection [0.1-0.2 ml/(kg · d)] by intravenous drip and ribavirin spray by conspergering into mouth cavity.All patients received pyretolysis treatment.The patients with bacterial infections were given antibiotics.The time of pyretolysis,extinction time of sore throat,salivation and herpes were observed for 5 days.Results The total effective rate in observation group [96.8 ％ (122/126)] was significantly higher than that in the control group [89.2％ (107/120)] (P ＜ 0.05).The time of pyretolysis,pharyngalgia and salivate disappear,herpes extinction in observation group were shorter than those in control group [(2.3 ±0.8)d vs(4.0 ± 1.0)d,(3.2 ± 1.4)d vs (4.4 ± 1.3)d,(3.2 ±0.7)d vs (5.0 ±0.6) d,all P ＜ 0.05].Conclusions Xiyanping injection combined with ribavirin spray on herpangina can shorten the pathogenesis,raise recovery rate,and has a significant effect on herpangina.
