CAJ | 학술논문

目的评价和比较服用标准剂量普伐他汀、辛伐他汀、洛伐他汀、阿托伐他汀、氟伐他汀后的冠心病罪犯血管内斑块负荷改变.方法随机入选2006年3月6日至2007年3月6日收治的、进入意向治疗及安全性分析的非经皮冠状动脉介入术治疗、具有心绞痛症状的患者45例,完成研究者32例.采用随机、开放、交叉的对照研究,患者被随机指定到5个药物治疗序列中的任何一个.研究药物20 mg 1次/d睡前服用,每种药物各服用6个月.每个治疗药物周期间隔至少10 d的洗脱期.应用血管内超声(IVUS)技术对罪犯血管内斑块负荷进行定量分析.结果阿托伐他汀治疗6个月后患者罪犯血管内斑块负荷减少百分比明显高于氟伐他汀、洛伐他汀、辛伐他汀、普伐他汀治疗后[(0.84±0.05)％比(0.44 ±0.22)％、(0.52±0.03)％、(0.39±0.07)％、(0.56±0.05)％,P＜0.01],心绞痛发作频率较基线时减少的次数明显多于氟伐他汀、洛伐他汀、辛伐他汀、普伐他汀治疗后[(13.4±1.1)次/周比(10.7±1.1)、(10.4±1.1)、(9.1±0.3)、(10.0±1.2)次/周,P＜0.01].结论对于有心绞痛症状的患者,每日20 mg标准剂量的阿托伐他汀比标准剂量的普伐他汀、辛伐他汀、洛伐他汀和氟伐他汀能够更加有效地将罪犯血管内斑块控制在稳态,从而有效减少心绞痛的发生.
목적 평개화비교복용표준제량보벌타정、신벌타정、락벌타정、아탁벌타정、불벌타정후적관심병죄범혈관내반괴부하개변.방법 수궤입선2006년3월6일지2007년3월6일수치적、진입의향치료급안전성분석적비경피관상동맥개입술치료、구유심교통증상적환자45례,완성연구자32례.채용수궤、개방、교차적대조연구,환자피수궤지정도5개약물치료서렬중적임하일개.연구약물20 mg 1차/d수전복용,매충약물각복용6개월.매개치료약물주기간격지소10 d적세탈기.응용혈관내초성(IVUS)기술대죄범혈관내반괴부하진행정량분석.결과 아탁벌타정치료6개월후환자죄범혈관내반괴부하감소백분비명현고우불벌타정、락벌타정、신벌타정、보벌타정치료후[(0.84±0.05)％비(0.44 ±0.22)％、(0.52±0.03)％、(0.39±0.07)％、(0.56±0.05)％,P＜0.01],심교통발작빈솔교기선시감소적차수명현다우불벌타정、락벌타정、신벌타정、보벌타정치료후[(13.4±1.1)차/주비(10.7±1.1)、(10.4±1.1)、(9.1±0.3)、(10.0±1.2)차/주,P＜0.01].결론 대우유심교통증상적환자,매일20 mg표준제량적아탁벌타정비표준제량적보벌타정、신벌타정、락벌타정화불벌타정능구경가유효지장죄범혈관내반괴공제재은태,종이유효감소심교통적발생.
Objective To evaluate the effects ofpravastatin,simvastatin,atorvastatin,lovastatin,fluvastatin on criminals endovascular plaques of patients with coronary artery disease (CHD).Methods Thirty-two CHD patients were randomly assigned to anyone of 5 medications sequences,respectively acceped pravastatin,simvastatin,atorvastatin,lovastatin,fluvastatin for 6 months,criminals endovascular endovascular plaques were quantitative analyzed by intravascular ultrasound (IVUS) technology during each drug treatment cycle.Results Plaque load change percentage reduced respectively,and the difference between atorvastatin and fluvastatin,lovastatin,simvastatin,pravastatin was statistical significant [(0.84 ± 0.05) ％ vs (0.44 ± 0.22) ％,(0.52 ± 0.03) ％,(0.39 ±0.07) ％,(0.56 ± 0.05) ％,P ＜ 0.01].Accordingly,incidence of angina of patients after treatment with atorvastatin administration reduced from (17.5 ± 1.5)times/week to (4.1 ± 0.4)times/week and was significantly more than other administration drugs [fluvastatin,lovastatin,simvastatin,pravastatin group was (10.7 ± 1.1),(10.4 ±1.1),(9.1 ± 0.3),(10.0 ± 1.2) times/week,respectively,P ＜ 0.01].Conclusion Standard doses of atorvastatin(20 mg daily) can more effectively stabilize criminals endovascular plaques than pravastatin,simvastatin,lovastatin,fluvastatin in patients with angina,thus it can effectively reduce the incidence of angina.