CAJ | 학술논문

目的探讨临床药师应用临床研究证据对普外科医师围手术期应用抗菌药物的干预效果.方法随机抽取我院2009年9月至2010年9月和2011年9月至2012年9月普外科手术后出院患者病历各60份.设计《外科手术围术期抗菌药物使用调查表》,临床药师查阅文献,结合临床证据进行宣教,提供较高证据级别文献供医生参考.对比临床药师干预前后普外科围手术期抗菌药物品种、时间、联合用药等情况.结果临床药师结合临床证据进行干预后,普外科围手术期抗菌药物选择、给药时机、术后用药、用法用量的合理比例较干预前明显升高,分别为70％(42/60)与50％ (30/60)(P＜0.05),97％(58/60)与52％(31/60)(P＜0.05),82％(49/60)与48％(29/60)(P＜0.05),87％(52/60)与80％ (48/60)(P＞0.05).结论临床药师通过检索文献,应用临床证据对医生提供有效的宣教和干预,能够更好地提高普外科围手术期抗菌药物使用合理率.
목적 탐토림상약사응용림상연구증거대보외과의사위수술기응용항균약물적간예효과.방법 수궤추취아원2009년9월지2010년9월화2011년9월지2012년9월보외과수술후출원환자병력각60빈.설계《외과수술위술기항균약물사용조사표》,림상약사사열문헌,결합림상증거진행선교,제공교고증거급별문헌공의생삼고.대비림상약사간예전후보외과위수술기항균약물품충、시간、연합용약등정황.결과 림상약사결합림상증거진행간예후,보외과위수술기항균약물선택、급약시궤、술후용약、용법용량적합리비례교간예전명현승고,분별위70％(42/60)여50％ (30/60)(P＜0.05),97％(58/60)여52％(31/60)(P＜0.05),82％(49/60)여48％(29/60)(P＜0.05),87％(52/60)여80％ (48/60)(P＞0.05).결론 림상약사통과검색문헌,응용림상증거대의생제공유효적선교화간예,능구경호지제고보외과위수술기항균약물사용합리솔.
Objective To investigate the effect of clinical pharmacists intervening with clinical evidence in prophylactic application of antibiotics during perioperative period in surgery department.Methods Totally 60 medical records were collected during September 2009 and September 2010 (former intervention)and September 2011 and September 2011 (new intervention),respectively.Questionnaire of surgical perioperative antimicrobial drug use was designed.Clinical pharmacists provided a high level of evidence literature for physicians through combined literature with clinical evidence missionary.The rationality of perioperative prophylactic application of antibiotics was compared in terms of antibiotics indication,medicine selection,usage and dosage,administration time and treatment course.Results After intervention of clinical pharmacists,the perioperative prophylactic application of antibiotics was improved significantly in respects of medicine selection,administration time,dosage and usage [70％ (42/60)vs 50％ (30/65 (P ＜0.05),97％ (58/60) vs (52％ (31/60) (P ＜0.05),82％ (49/60) vs 48％ (29/60) (P ＜0.05),87％ (52/60) vs 80％ (48/60) (P ＞ 0.05)].Conclusion It is effective and practicable for clinical pharmacists to intervene with clinical evidences in prophylactic application of antibiotics during perioperative period in general surgery department.