中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
10期
1390-1392
,共3页
李榕%楼煜清%颜波%马美丽%裴俊%韩宝惠
李榕%樓煜清%顏波%馬美麗%裴俊%韓寶惠
리용%루욱청%안파%마미려%배준%한보혜
肺癌%维生素D受体%基因多态性
肺癌%維生素D受體%基因多態性
폐암%유생소D수체%기인다태성
Lung cancer%Vitamin D receptor%Single nucleotide polymorphism
目的 探讨维生素D受体基因rs7975232位点与汉族人群肺癌发病风险的相关性.方法 用直接测序法对72例肺癌患者及67名健康对照者进行单核苷酸多态性位点检测,采用ABI3700XL基因分析仪测序.结果 维生素D受体基因rs7975232位点等位基因A携带者肺癌发病风险明显低于等位基因C携带者[比值比(OR) =0.501,95％置信区间(CI)为0.273 ～0.920,P=0.026].rs7975232位点可能与鳞癌发病相关(等位基因之比:OR=0.274,95％ CI为0.087 ～0.861,P=0.027;显性基因模型:OR =0.269,95％ CI为0.074 ～0.971,P=0.045).结论 维生素D受体基因rs7975232位点与肺癌发病相关.
目的 探討維生素D受體基因rs7975232位點與漢族人群肺癌髮病風險的相關性.方法 用直接測序法對72例肺癌患者及67名健康對照者進行單覈苷痠多態性位點檢測,採用ABI3700XL基因分析儀測序.結果 維生素D受體基因rs7975232位點等位基因A攜帶者肺癌髮病風險明顯低于等位基因C攜帶者[比值比(OR) =0.501,95％置信區間(CI)為0.273 ～0.920,P=0.026].rs7975232位點可能與鱗癌髮病相關(等位基因之比:OR=0.274,95％ CI為0.087 ～0.861,P=0.027;顯性基因模型:OR =0.269,95％ CI為0.074 ～0.971,P=0.045).結論 維生素D受體基因rs7975232位點與肺癌髮病相關.
목적 탐토유생소D수체기인rs7975232위점여한족인군폐암발병풍험적상관성.방법 용직접측서법대72례폐암환자급67명건강대조자진행단핵감산다태성위점검측,채용ABI3700XL기인분석의측서.결과 유생소D수체기인rs7975232위점등위기인A휴대자폐암발병풍험명현저우등위기인C휴대자[비치비(OR) =0.501,95％치신구간(CI)위0.273 ～0.920,P=0.026].rs7975232위점가능여린암발병상관(등위기인지비:OR=0.274,95％ CI위0.087 ～0.861,P=0.027;현성기인모형:OR =0.269,95％ CI위0.074 ～0.971,P=0.045).결론 유생소D수체기인rs7975232위점여폐암발병상관.
Objective To reveal the relationship between vitamin D receptor (VDR) gene rs7975232 single nucleotide polymorphism (SNP) and lung cancer risk in Chinese Han population.Methods A total of 72 patients with lung cancer and 67 healthy controls were in this study.SNP loci were detected by direct sequencing,sequencing by ABI3700XL Genetic Analyzer.Results VDR gene rs7975232 locus allele A carriers risk of lung cancer was significandy lower than the C allele carriers [odds ratio (OR) =0.501,95％ confidence interval (CI) =0.273-0.920,P =0.026].rs7975232 locus may be associated with squamous cell carcinoma [allele ratio:P =0.027,0R =0.274,95％ CI(O.087-0.861) ; dominant gene model:P =0.045,OR =0.269,95％ CI(0.074-0.971)].Conclusion VDR gene the rs7975232 locus is related to lung cancer pathogenesis.
