中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
11期
1612-1614
,共3页
卢维晟%张江蓉%高艳虹%袁惠敏%王一尘
盧維晟%張江蓉%高豔虹%袁惠敏%王一塵
로유성%장강용%고염홍%원혜민%왕일진
骨钙素%骨质疏松%冠状动脉钙化%老年男性
骨鈣素%骨質疏鬆%冠狀動脈鈣化%老年男性
골개소%골질소송%관상동맥개화%노년남성
Osteocalcin%Osteoporosis%Coronary artery calcification%Elderly men
目的 探讨血清骨钙素水平与老年骨质疏松及冠状动脉病变的相关性.方法 选取183例年龄在60 ～ 85岁的患者,根据骨密度测定结果分为2组:非骨质疏松组86例,骨质疏松组97例；根据冠状动脉螺旋CT检查结果分为3组:轻度钙化组(积分＜200)68例；中度钙化组(200≤积分＜300)43例；重度钙化组(积分≥300)72例.比较各组患者的冠状动脉狭窄病变和钙化程度.应用酶联免疫吸附试验者测定各组患者血清骨钙素水平.结果 骨质疏松组患者合并肥胖、高血压、高血脂和糖尿病的比例分别为56.7％(55/97)、80.4％(78/97)、78.4％(76/97)、71.1％ (69/97),高于非骨质疏松组的37.2％ (32/86)、54.7％(47/86)、44.2％(38/86)、31.4％(27/86)(P＜0.05)；骨质疏松组患者血清骨钙素水平明显低于非骨质疏松组患者[(14±3)ng/L比(42±6)ng/L(P ＜0.05)]；骨质疏松组患者任意冠状动脉分支的钙化程度均高于非骨质疏松组,2组比较差异有统计学意义(P＜0.05).骨质疏松组冠状动脉单支病变超过50％狭窄者比例明显高于非骨质疏松组,冠状动脉2支以上病变者占比更高[20.6％ (20/97)比3.5％ (3/86)],差异均有统计学意义(均P＜0.05).冠状动脉血清骨钙素水平分别为(45.6±8.3)、(26.2±4.8)、(15.5±10.2) ng/L,任意两两比较差异均有统计学意义(均P＜0.01).结论 骨钙流失与钙质在冠状动脉的沉积存在共同的发病机制.该机制与血清骨钙素水平有关,血清骨钙素对老年男性骨质疏松与冠状动脉钙化有保护作用.
目的 探討血清骨鈣素水平與老年骨質疏鬆及冠狀動脈病變的相關性.方法 選取183例年齡在60 ～ 85歲的患者,根據骨密度測定結果分為2組:非骨質疏鬆組86例,骨質疏鬆組97例；根據冠狀動脈螺鏇CT檢查結果分為3組:輕度鈣化組(積分＜200)68例；中度鈣化組(200≤積分＜300)43例；重度鈣化組(積分≥300)72例.比較各組患者的冠狀動脈狹窄病變和鈣化程度.應用酶聯免疫吸附試驗者測定各組患者血清骨鈣素水平.結果 骨質疏鬆組患者閤併肥胖、高血壓、高血脂和糖尿病的比例分彆為56.7％(55/97)、80.4％(78/97)、78.4％(76/97)、71.1％ (69/97),高于非骨質疏鬆組的37.2％ (32/86)、54.7％(47/86)、44.2％(38/86)、31.4％(27/86)(P＜0.05)；骨質疏鬆組患者血清骨鈣素水平明顯低于非骨質疏鬆組患者[(14±3)ng/L比(42±6)ng/L(P ＜0.05)]；骨質疏鬆組患者任意冠狀動脈分支的鈣化程度均高于非骨質疏鬆組,2組比較差異有統計學意義(P＜0.05).骨質疏鬆組冠狀動脈單支病變超過50％狹窄者比例明顯高于非骨質疏鬆組,冠狀動脈2支以上病變者佔比更高[20.6％ (20/97)比3.5％ (3/86)],差異均有統計學意義(均P＜0.05).冠狀動脈血清骨鈣素水平分彆為(45.6±8.3)、(26.2±4.8)、(15.5±10.2) ng/L,任意兩兩比較差異均有統計學意義(均P＜0.01).結論 骨鈣流失與鈣質在冠狀動脈的沉積存在共同的髮病機製.該機製與血清骨鈣素水平有關,血清骨鈣素對老年男性骨質疏鬆與冠狀動脈鈣化有保護作用.
목적 탐토혈청골개소수평여노년골질소송급관상동맥병변적상관성.방법 선취183례년령재60 ～ 85세적환자,근거골밀도측정결과분위2조:비골질소송조86례,골질소송조97례；근거관상동맥라선CT검사결과분위3조:경도개화조(적분＜200)68례；중도개화조(200≤적분＜300)43례；중도개화조(적분≥300)72례.비교각조환자적관상동맥협착병변화개화정도.응용매련면역흡부시험자측정각조환자혈청골개소수평.결과 골질소송조환자합병비반、고혈압、고혈지화당뇨병적비례분별위56.7％(55/97)、80.4％(78/97)、78.4％(76/97)、71.1％ (69/97),고우비골질소송조적37.2％ (32/86)、54.7％(47/86)、44.2％(38/86)、31.4％(27/86)(P＜0.05)；골질소송조환자혈청골개소수평명현저우비골질소송조환자[(14±3)ng/L비(42±6)ng/L(P ＜0.05)]；골질소송조환자임의관상동맥분지적개화정도균고우비골질소송조,2조비교차이유통계학의의(P＜0.05).골질소송조관상동맥단지병변초과50％협착자비례명현고우비골질소송조,관상동맥2지이상병변자점비경고[20.6％ (20/97)비3.5％ (3/86)],차이균유통계학의의(균P＜0.05).관상동맥혈청골개소수평분별위(45.6±8.3)、(26.2±4.8)、(15.5±10.2) ng/L,임의량량비교차이균유통계학의의(균P＜0.01).결론 골개류실여개질재관상동맥적침적존재공동적발병궤제.해궤제여혈청골개소수평유관,혈청골개소대노년남성골질소송여관상동맥개화유보호작용.
Objective To determine osteocalcin in serum in elderly man; to discuss the effects of abnormal calcium metabolism between osteoporosis and coronary artery calcification in elderly men.Methods According to the results of the bone density,183 patients with an age from 60 to 85 (72 ± 8.8),were divided into two groups:non-osteoporosis group(n =86) and osteoporosis group(n =97).According to the results of coronary artery spiral CT,the patients mentioned above were divided into three groups:mild calcification group (calcification score ＜200,n =68),middle calcification group (calcification score ≥ 200 and ＜ 300,n =43) and severe calcification group (calcification score≥300,n =72).The stenosis of coronary artery and the degree of calcification were compared among the groups.Osteocalcin in serum was determined by using enzyme linked immunosorbent assay and its results were compared among the groups.Results The proportions of obesity,hypertension,hyperlipidemia and diabetes were larger in osteoporosis group.Osteocalcin in serum of osteoporosis group was higher than that of non-osteoporosis group.The degree of calcification in any branch of coronary artery of osteoporosis group was higher than that of non-osteoporosis group and there was a statistical significance between the two groups.The proportion of osteoporosis group was higher than that of non-osteoporosis group.The proportion of osteoporosis group was much higher than that of non-osteoporosis group.Osteocalcin in serum was decreased with the exacerbation of calcification of coronary artery and there was a statistical significance between osteocalcin and coronary artery calcification.Conclusions There is the same pathogenesis between the loss of calcium in bone and calcium deposition in coronary artery.This mechanism is related to osteocalcin in serum.Osteocalcin in serum avoids osteoporosis and coronary artery calcification.
