CAJ | 학술논문

目的探讨复发性流产(RSA)与5种自身免疫性抗体的相关性.方法采用酶联免疫吸附试验对186例RSA妇女(流产组)和100例正常妊娠妇女(对照组)进行血清抗心磷脂抗体(ACAb)、抗卵巢抗体(AOAb)、抗精子抗体(ASAb)、抗子宫内膜抗体(EMAb)及抗绒毛膜促性腺激素抗体(HCGAb)的检测并加以比较分析.结果流产组妇女ACAb、AOAb、ASAb、EMAb和HCGAb的检出率分别为45.7％(85例)、29.6％(55例)、26.9％(50例)、43.0％(80例)和25.8％(48例),明显高于对照组的6.0％(6例)、2.0％(2例)、5.0％(5例)、2.0％(2例)和4.0％(4例)(均P＜0.01).流产3、4、5次的5种抗体检出率明显高于流产2次者,差异均有统计学意义(P＜0.05或P＜0.01).结论 ACAb、AOAb、ASAb、EMAb、HCGAb与RSA有明显的关系,是造成RSA的重要因素,进行这5种自身免疫性抗体的检测,对RSA的临床诊治有指导意义.
목적 탐토복발성유산(RSA)여5충자신면역성항체적상관성.방법 채용매련면역흡부시험대186례RSA부녀(유산조)화100례정상임신부녀(대조조)진행혈청항심린지항체(ACAb)、항란소항체(AOAb)、항정자항체(ASAb)、항자궁내막항체(EMAb)급항융모막촉성선격소항체(HCGAb)적검측병가이비교분석.결과 유산조부녀ACAb、AOAb、ASAb、EMAb화HCGAb적검출솔분별위45.7％(85례)、29.6％(55례)、26.9％(50례)、43.0％(80례)화25.8％(48례),명현고우대조조적6.0％(6례)、2.0％(2례)、5.0％(5례)、2.0％(2례)화4.0％(4례)(균P＜0.01).유산3、4、5차적5충항체검출솔명현고우유산2차자,차이균유통계학의의(P＜0.05혹P＜0.01).결론 ACAb、AOAb、ASAb、EMAb、HCGAb여RSA유명현적관계,시조성RSA적중요인소,진행저5충자신면역성항체적검측,대RSA적림상진치유지도의의.
Objective To investigate the relation between recurrent spontaneous abortion (RSA) and autoantibodies.Methods Serum anticardiolipin antibody(ACAb),antiovarian antibody(AOAb),antisperm antibody (ASAb),antiendometrial antibody(EMAb) and anti-HCG antibody(HCGAb) of 186 cases with recurrent spontaneous abortion(abortion group) and 100 normal controls(control group) were detected.Results The positive rates of ACAb,AOAb,ASAb,EMAb and HCGAb in abortion group were 45.7％ (85 cases),29.6％ (55 cases),26.9％(50 cases),43.0％ (80 cases) and 25.8％ (48 cases) respectively,while 6.0％ (6 cases),2.0％ (2 cases),5.0％ (5 cases),2.0％ (2 cases) and 4.0％ (4 cases) in control group.There was significant difference between two groups(all P ＜0.01).The positive rates of these five antibodies in abortion three,four and five times patients were higher than abortion two times patients,and there were significant differences (P ＜ 0.05 or P ＜ 0.01).Conclusions ACAb,AOAb,ASAb,EMAb,HCGAb are all related to RSA.Detection of the above five antibodies can help diagnosis and treatment of RSA.