中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
z1期
24-26
,共3页
曹永吉%师爱香%孙克德%周智勇%刘彤
曹永吉%師愛香%孫剋德%週智勇%劉彤
조영길%사애향%손극덕%주지용%류동
口服葡萄糖耐量试验%1小时血糖%糖调节受损%胰岛β细胞功能%胰岛素抵抗
口服葡萄糖耐量試驗%1小時血糖%糖調節受損%胰島β細胞功能%胰島素牴抗
구복포도당내량시험%1소시혈당%당조절수손%이도β세포공능%이도소저항
Oral glucose tolerance test%One hour plasma glucose%Impaired glucose regulation%Islet β cell function%Insulin resistance
目的 探讨口服葡萄糖耐量试验(OGTT)中1h血糖(1 hPG)升高者的胰岛β细胞功能状态.方法 入选体检中发现空腹血糖(FPG)升高,但未达到T2DM诊断标准而来内分泌科门诊就诊的354例患者,按WHO标准分为糖耐量正常(NGT)组(74例)、空腹血糖受损(IFG)组(43例)、糖耐量低减(IGT)组(54例)、联合血糖受损(CGI)组(47例)和DM组(136例).应用受试者工作特征曲线(ROC)分析所得1 hPG诊断IGR和2型糖尿病的切点值对354例受试者进行分组,细分为1 h-NGT组、1 h IGR组和1 h-DM组；分别计算胰岛素抵抗指数(HOMA-IR)、胰岛功能指数(HOMA-3)、胰岛β细胞早期分泌功能评估指标(△G0-30、△10-30、△10-30/△G0-30),并与WHO标准分组进行比较.结果 ①依1 h-NGT、1 h-IGR和1 h-DM的顺序HOMA-β(21±12、18±7、16±9)、△10-30/△G0-30 (0.55±1.37、0.33±0.19、0.26±0.14)逐渐降低,HO-MA-IR(0.55±0.16、0.63±0.19、0.75±0.24)逐渐升高,组间比较差异有统计学意义(P＜0.05).②1 hPG与几项指标均有很好的相关性(r=-0.292,-0.168,0.113,0.418,P＜0.05).结论 1 hPG能够很好地反映胰岛β细胞功能,是血糖分类中的一项重要指标,是对WHO标准的有益补充.
目的 探討口服葡萄糖耐量試驗(OGTT)中1h血糖(1 hPG)升高者的胰島β細胞功能狀態.方法 入選體檢中髮現空腹血糖(FPG)升高,但未達到T2DM診斷標準而來內分泌科門診就診的354例患者,按WHO標準分為糖耐量正常(NGT)組(74例)、空腹血糖受損(IFG)組(43例)、糖耐量低減(IGT)組(54例)、聯閤血糖受損(CGI)組(47例)和DM組(136例).應用受試者工作特徵麯線(ROC)分析所得1 hPG診斷IGR和2型糖尿病的切點值對354例受試者進行分組,細分為1 h-NGT組、1 h IGR組和1 h-DM組；分彆計算胰島素牴抗指數(HOMA-IR)、胰島功能指數(HOMA-3)、胰島β細胞早期分泌功能評估指標(△G0-30、△10-30、△10-30/△G0-30),併與WHO標準分組進行比較.結果 ①依1 h-NGT、1 h-IGR和1 h-DM的順序HOMA-β(21±12、18±7、16±9)、△10-30/△G0-30 (0.55±1.37、0.33±0.19、0.26±0.14)逐漸降低,HO-MA-IR(0.55±0.16、0.63±0.19、0.75±0.24)逐漸升高,組間比較差異有統計學意義(P＜0.05).②1 hPG與幾項指標均有很好的相關性(r=-0.292,-0.168,0.113,0.418,P＜0.05).結論 1 hPG能夠很好地反映胰島β細胞功能,是血糖分類中的一項重要指標,是對WHO標準的有益補充.
목적 탐토구복포도당내량시험(OGTT)중1h혈당(1 hPG)승고자적이도β세포공능상태.방법 입선체검중발현공복혈당(FPG)승고,단미체도T2DM진단표준이래내분비과문진취진적354례환자,안WHO표준분위당내량정상(NGT)조(74례)、공복혈당수손(IFG)조(43례)、당내량저감(IGT)조(54례)、연합혈당수손(CGI)조(47례)화DM조(136례).응용수시자공작특정곡선(ROC)분석소득1 hPG진단IGR화2형당뇨병적절점치대354례수시자진행분조,세분위1 h-NGT조、1 h IGR조화1 h-DM조；분별계산이도소저항지수(HOMA-IR)、이도공능지수(HOMA-3)、이도β세포조기분비공능평고지표(△G0-30、△10-30、△10-30/△G0-30),병여WHO표준분조진행비교.결과 ①의1 h-NGT、1 h-IGR화1 h-DM적순서HOMA-β(21±12、18±7、16±9)、△10-30/△G0-30 (0.55±1.37、0.33±0.19、0.26±0.14)축점강저,HO-MA-IR(0.55±0.16、0.63±0.19、0.75±0.24)축점승고,조간비교차이유통계학의의(P＜0.05).②1 hPG여궤항지표균유흔호적상관성(r=-0.292,-0.168,0.113,0.418,P＜0.05).결론 1 hPG능구흔호지반영이도β세포공능,시혈당분류중적일항중요지표,시대WHO표준적유익보충.
Objective To discuss the relationship of the levels of 1-h plasma glucose (1 h PG) in oral glucose tolerance test (OGTT) and islet β-cell function.Methods 354 out-patients with increasing plasma glucose levels,but not to type 2 diabetes diagnosis standard were divided into normal glucose tolerance (NGT) group (74 cases),impaired fasting glucose (IFG) group (43 cases),impaired glucose tolerance (IGT) group (54 cases),combined glucose intolerance (GGI) group (47 cases) and DM group (136 cases).According the results of the levels of 1 h PG in receiver operating characteristic curve(ROC) which diagnosed impaired glucose regulation(IGR) and type 2 diabetes mellitus (T2DM) were classified into 1 h-NGT group,1 h-IGR group and 1 h-DM group; respectively calculated the results of HOMA-IR,HOMA-β,△I0-30,△I0-30/G0-30,and compared with the standard group of WHO.Results ①In accordance with 1 h-NGT,1 h-IGR and 1 h-DM order,the results of HOMA-β (21 ± 12,18 ±7,16 ±9),△I0-30/G0-30(0.55 ± 1.37,0.33 ±0.19,0.26 ±0.14) gradually reduced,the results of HOMA-IR(0.55 ± 0.16,0.63 ± 0.19,0.75 ± 0.24) gradually raised,the difference compared with groups was significantly (P ＜ 0.05).②There had a good correlation with 1 h PG and several indexes (r =-0.292,-0.168,0.113,0.418,P ＜ 0.05).Conclusions 1 h PG can well responsed the function of islet β-cell.It is an important index in plasma glucose classification and a beneficial supplement to the WHO standard.
