中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
2期
153-155
,共3页
原发性高血压%硝苯地平%卡托普利%心率%血管紧张素
原髮性高血壓%硝苯地平%卡託普利%心率%血管緊張素
원발성고혈압%초분지평%잡탁보리%심솔%혈관긴장소
Essential hypertension%Nifedipine%Captopril%Heart rate%Angiotensin
目的 探讨硝苯地平联合卡托普利治疗原发性高血压的临床效果.方法 将2009年1月至2012年12月就诊的原发性高血压患者102例,完全随机分为对照组和治疗组,各51例.对照组给予卡托普利片20 mg/次,3次/d;治疗组给予卡托普利片20 mg/次,3次/d和硝苯地平控释片30 mg/次,1次/d.连续用药8周.比较2组患者血压、心率、血尿素氮、肌酐与β2微球蛋白.结果 治疗组总有效率为88.3％(45/51),明显高于对照组的72.5％(37/51),差异有统计学意义(P＜0.05);对照组治疗后收缩压、舒张压、心率均低于治疗前[分别为(137 ±8)mmHg(1 mmHg =0.133 kPa)比(153±9)mmHg、(92±7)mmHg比(97±6)mmHg、(77 ±6)次/min比(87±6)次/min,均P＜0.05];治疗组治疗后舒张压、收缩压、心率均低于治疗前[分别为(129±7)mmHg比(153±10) mmHg、(89±6)mmHg比(97±6)mmHg、(75±5)次/min比(86±6)次/min,均P＜0.05].治疗组治疗后收缩压和舒张压低于对照组,差异有统计学意义(P＜0.05).对照组治疗前血尿素氮、肌酐和β2微球蛋白分别为(6.8±0.9)mmol/L、(107±13) mmol/L、(687±81)μg/L;治疗后分别为(6.2±0.9) mmol/L、(104±12) mmol/L、(427 ±55) μg/L;治疗组治疗前尿素氮、肌酐和β2微球蛋白分别为(6.6±0.6)mmol/L、(106±12) mmol/L、(683±76) μg/L;治疗后分别为(6.0 ± 0.7) mmol/L、(102±12) mmol/L、(414 ±53) μg/L.2组患者治疗后血尿素氮和β2微球蛋白较本组治疗前明显下降,差异有统计学意义(P＜0.05).结论 硝苯地平联合卡托普利治疗原发性高血压具有明显的降压作用,疗效较好,不良反应少.
目的 探討硝苯地平聯閤卡託普利治療原髮性高血壓的臨床效果.方法 將2009年1月至2012年12月就診的原髮性高血壓患者102例,完全隨機分為對照組和治療組,各51例.對照組給予卡託普利片20 mg/次,3次/d;治療組給予卡託普利片20 mg/次,3次/d和硝苯地平控釋片30 mg/次,1次/d.連續用藥8週.比較2組患者血壓、心率、血尿素氮、肌酐與β2微毬蛋白.結果 治療組總有效率為88.3％(45/51),明顯高于對照組的72.5％(37/51),差異有統計學意義(P＜0.05);對照組治療後收縮壓、舒張壓、心率均低于治療前[分彆為(137 ±8)mmHg(1 mmHg =0.133 kPa)比(153±9)mmHg、(92±7)mmHg比(97±6)mmHg、(77 ±6)次/min比(87±6)次/min,均P＜0.05];治療組治療後舒張壓、收縮壓、心率均低于治療前[分彆為(129±7)mmHg比(153±10) mmHg、(89±6)mmHg比(97±6)mmHg、(75±5)次/min比(86±6)次/min,均P＜0.05].治療組治療後收縮壓和舒張壓低于對照組,差異有統計學意義(P＜0.05).對照組治療前血尿素氮、肌酐和β2微毬蛋白分彆為(6.8±0.9)mmol/L、(107±13) mmol/L、(687±81)μg/L;治療後分彆為(6.2±0.9) mmol/L、(104±12) mmol/L、(427 ±55) μg/L;治療組治療前尿素氮、肌酐和β2微毬蛋白分彆為(6.6±0.6)mmol/L、(106±12) mmol/L、(683±76) μg/L;治療後分彆為(6.0 ± 0.7) mmol/L、(102±12) mmol/L、(414 ±53) μg/L.2組患者治療後血尿素氮和β2微毬蛋白較本組治療前明顯下降,差異有統計學意義(P＜0.05).結論 硝苯地平聯閤卡託普利治療原髮性高血壓具有明顯的降壓作用,療效較好,不良反應少.
목적 탐토초분지평연합잡탁보리치료원발성고혈압적림상효과.방법 장2009년1월지2012년12월취진적원발성고혈압환자102례,완전수궤분위대조조화치료조,각51례.대조조급여잡탁보리편20 mg/차,3차/d;치료조급여잡탁보리편20 mg/차,3차/d화초분지평공석편30 mg/차,1차/d.련속용약8주.비교2조환자혈압、심솔、혈뇨소담、기항여β2미구단백.결과 치료조총유효솔위88.3％(45/51),명현고우대조조적72.5％(37/51),차이유통계학의의(P＜0.05);대조조치료후수축압、서장압、심솔균저우치료전[분별위(137 ±8)mmHg(1 mmHg =0.133 kPa)비(153±9)mmHg、(92±7)mmHg비(97±6)mmHg、(77 ±6)차/min비(87±6)차/min,균P＜0.05];치료조치료후서장압、수축압、심솔균저우치료전[분별위(129±7)mmHg비(153±10) mmHg、(89±6)mmHg비(97±6)mmHg、(75±5)차/min비(86±6)차/min,균P＜0.05].치료조치료후수축압화서장압저우대조조,차이유통계학의의(P＜0.05).대조조치료전혈뇨소담、기항화β2미구단백분별위(6.8±0.9)mmol/L、(107±13) mmol/L、(687±81)μg/L;치료후분별위(6.2±0.9) mmol/L、(104±12) mmol/L、(427 ±55) μg/L;치료조치료전뇨소담、기항화β2미구단백분별위(6.6±0.6)mmol/L、(106±12) mmol/L、(683±76) μg/L;치료후분별위(6.0 ± 0.7) mmol/L、(102±12) mmol/L、(414 ±53) μg/L.2조환자치료후혈뇨소담화β2미구단백교본조치료전명현하강,차이유통계학의의(P＜0.05).결론 초분지평연합잡탁보리치료원발성고혈압구유명현적강압작용,료효교호,불량반응소.
Objective To investigate combined therapeutic effect of nifedipine and captopril treating essential hypertension.Methods One hundred and two patients of essential hypertension were divided into treatment group and control group,with 51 cases in each group.The control group had captopril 20 mg; the treatment group received captopril 20 mg and nifedipine 30 mg pertime for 8 weeks.Results The total effective rate of treatment group was 88.3％ (45/51),which was significantly higher than that of the control group[72.5％ (37/51)] (P ＜ 0.05).After treatment,systolic blood pressure,diastolic blood pressure and heart rate in control groupwere lower than those of before treatment [respectively (137 ± 8) mmHg vs (153 ± 9) mmHg,(92 ± 7) mmHg vs (97 ±6) mmHg,(77 ±6) beats/min vs (87 ± 6) times/min] ; after treatment systolic blood pressure,diastolic blood pressure,heart rate in treatment group were lower than those of before treatment [(129 ± 7) mmHg vs (153±10) mmHg,(89 ±6) mmHg vs (97 ±6) mmHg,(75 ± 5) beats/min vs (86 ± 6) times/min],the differences were statistically significant (P ＜ 0.05).Before and after treatment in the control group,the blood serum urea nitrogen(BUN),creatinine (Cr) and β32-microglobulin were respectively (6.8 ± 0.9) mmol/L,(6.2 ±0.9) mmol/L,(107±13) mmol/L,(104±12) mmol/L,(687±81) μg/L,(427 ±55) μg/L,while in the treatment group they were (6.6 ± 0.6) mmol/L,(6.0 ± 0.7) mmol/L,(106 ± 12) mmol/L,(102 ± 12) mmol/L,(683 ±76) μg/L,(414 ±53) μg/L.The BUN,Cr and β2-microglobulin decreased after treatment.Conclusion The combined therapeutic effect of nifedipine and captopril have a good curative effect on essential hypertension.
