中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
2期
244-246
,共3页
晚期卵巢癌%益气活血解毒方%无进展生存期%生活质量
晚期卵巢癌%益氣活血解毒方%無進展生存期%生活質量
만기란소암%익기활혈해독방%무진전생존기%생활질량
Advanced ovarian cancer%Tonifying qi and activating blood and detoxification decoction%Time-to-relapse%Quality of life
目的 观察益气活血解毒方对晚期卵巢癌患者无复发生存时间及生活质量的影响.方法 选取2009-2013年中国中医科学院广安门医院125例晚期卵巢癌一线治疗病灶完全消失后复发的患者,根据是否采用中药干预分为中药组(50例)及对照组(75例).中药组给予手术治疗及化疗后服用益气活血解毒方,对照组给予西医手术治疗及化疗.采集2组患者基本情况及无复发生存时间,并采用卵巢癌治疗功能评价系统的健康状态评分、卡氏评分和中医症状积分评估2组患者的生活质量.结果 中药组无复发生存时间为18.5个月,对照组无复发生存时间16.0个月,Kaplan-Meier曲线显示中药维持治疗可延长中位无复发生存期(log rank:P=0.006).中药组复发时生活质量卵巢癌治疗功能评价系统积分、卡氏评分及症状积分与对照组比较,差异均有统计学意义[(20.1±2.6)分比(24.8 ±4.0)分,(79±9)分比(72±9)分,(12.7±2.4)分比(16.6±3.2)分,均P＜0.05].结论 益气活血解毒方能延长晚期卵巢癌患者的无复发生存期,提高其生活质量.
目的 觀察益氣活血解毒方對晚期卵巢癌患者無複髮生存時間及生活質量的影響.方法 選取2009-2013年中國中醫科學院廣安門醫院125例晚期卵巢癌一線治療病竈完全消失後複髮的患者,根據是否採用中藥榦預分為中藥組(50例)及對照組(75例).中藥組給予手術治療及化療後服用益氣活血解毒方,對照組給予西醫手術治療及化療.採集2組患者基本情況及無複髮生存時間,併採用卵巢癌治療功能評價繫統的健康狀態評分、卡氏評分和中醫癥狀積分評估2組患者的生活質量.結果 中藥組無複髮生存時間為18.5箇月,對照組無複髮生存時間16.0箇月,Kaplan-Meier麯線顯示中藥維持治療可延長中位無複髮生存期(log rank:P=0.006).中藥組複髮時生活質量卵巢癌治療功能評價繫統積分、卡氏評分及癥狀積分與對照組比較,差異均有統計學意義[(20.1±2.6)分比(24.8 ±4.0)分,(79±9)分比(72±9)分,(12.7±2.4)分比(16.6±3.2)分,均P＜0.05].結論 益氣活血解毒方能延長晚期卵巢癌患者的無複髮生存期,提高其生活質量.
목적 관찰익기활혈해독방대만기란소암환자무복발생존시간급생활질량적영향.방법 선취2009-2013년중국중의과학원엄안문의원125례만기란소암일선치료병조완전소실후복발적환자,근거시부채용중약간예분위중약조(50례)급대조조(75례).중약조급여수술치료급화료후복용익기활혈해독방,대조조급여서의수술치료급화료.채집2조환자기본정황급무복발생존시간,병채용란소암치료공능평개계통적건강상태평분、잡씨평분화중의증상적분평고2조환자적생활질량.결과 중약조무복발생존시간위18.5개월,대조조무복발생존시간16.0개월,Kaplan-Meier곡선현시중약유지치료가연장중위무복발생존기(log rank:P=0.006).중약조복발시생활질량란소암치료공능평개계통적분、잡씨평분급증상적분여대조조비교,차이균유통계학의의[(20.1±2.6)분비(24.8 ±4.0)분,(79±9)분비(72±9)분,(12.7±2.4)분비(16.6±3.2)분,균P＜0.05].결론 익기활혈해독방능연장만기란소암환자적무복발생존기,제고기생활질량.
Objective To observe the effect of Tonifying Qi Activating Blood Detoxification Decoction on the time-to-relapse and quality of life of patients with advanced ovarian cancer.Methods Totally 125 patients with advanced ovarian cancer initially achieving completely remission (CR) were divided into Chinese medicine group (50 cases) and control group (75 cases).Chinese medicine group was given Tonifying Qi Activating Blood Detoxification Decoction after surgery and chemotherapy; control group was given surgery and chemotherapy.Functional assessment of cancer therapy-ovary (FACT-O),Karnofsky score and symptoms of TCM of two groups were analyzed.Results The median time-to-relapse (TTR) was 18.5 months for Chinese medicine group and 16 months for the control group.Kaplan-Meier curves demonstrated significantly positive prognosis for TCM maintenance of TTR (log rank:P =0.006).There were significant differences between the two groups regarding scores of FACT-O,arnofsky and TCM symptom [(20.1 ± 2.6) scores vs (24.8 ± 4.0) scores,(79 ± 9) scores vs (72 ± 9) scores,(12.7 ±82.4) scores vs (16.6 ± 3.2) scores] (P ＜ 0.05).Conclusion Tonifying Qi Activating Blood Detoxification Decoction can improve the time-to-relapse and quality of life of advanced ovarian cancer.
