中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
2期
266-268
,共3页
金黄色葡萄球菌%耐甲氧西林金黄色葡萄球菌%耐药率%复方新诺明%β内酰胺酶
金黃色葡萄毬菌%耐甲氧西林金黃色葡萄毬菌%耐藥率%複方新諾明%β內酰胺酶
금황색포도구균%내갑양서림금황색포도구균%내약솔%복방신낙명%β내선알매
Staphylococcus aureus%Methicillin resistant staphylococcus aureus%Resistant%Cotrimoxazole%Beta-lactamase
目的 回顾性分析痰标本中金黄色葡萄球菌的临床分布和耐药情况,为预防控制措施的制定提供依据.方法 对2009年1月至2013年9月内蒙古自治区人民医院临床分离的309株金黄色葡萄球菌进行分析,细菌鉴定和药敏试验采用VITEK 2 Compact全自动细菌培养鉴定仪.结果 耐甲氧西林金黄色葡萄球菌(MRSA)的分离率为78.6％(243/309),β内酰胺酶阳性金黄色葡萄球菌分离率为90.0％(278/309);金黄色葡萄球菌的病区来源主要为神经内科[30.7％ (95/309)]、重症监护病房[22.0％(68/309)]、神经外科[16.5％(51/309)]、呼吸内科[9.4％ (29/309)].金黄色葡萄球菌对万古霉素、替考拉宁、奎奴普丁/达福普汀和呋喃妥因的耐药率≤2.1％,MRSA与对甲氧西林敏感的金黄色葡萄球菌(MSSA)以及β内酰胺酶阳性金黄色葡萄球菌与β内酰胺酶阴性金黄色葡萄球菌间的耐药性差异无统计学意义(P＞0.05);对复方新诺明的耐药性MRSA低于MSSA(P ＜0.05),β内酰胺酶阳性低于β内酰胺酶阴性金黄色葡萄球菌(P＜0.05).对其他抗菌药物的耐药性MRSA高于MSSA(P ＜0.05);β内酰胺酶阳性高于β内酰胺酶阴性金黄色葡萄球菌,但除左旋氧氟沙星外(P＜0.05),其他差异均无统计学意义(P＞0.05).结论 MRSA和β内酰胺酶阳性金黄色葡萄球菌的检出率和耐药性较高,临床应依据药敏试验监测结果合理选择抗菌药物.
目的 迴顧性分析痰標本中金黃色葡萄毬菌的臨床分佈和耐藥情況,為預防控製措施的製定提供依據.方法 對2009年1月至2013年9月內矇古自治區人民醫院臨床分離的309株金黃色葡萄毬菌進行分析,細菌鑒定和藥敏試驗採用VITEK 2 Compact全自動細菌培養鑒定儀.結果 耐甲氧西林金黃色葡萄毬菌(MRSA)的分離率為78.6％(243/309),β內酰胺酶暘性金黃色葡萄毬菌分離率為90.0％(278/309);金黃色葡萄毬菌的病區來源主要為神經內科[30.7％ (95/309)]、重癥鑑護病房[22.0％(68/309)]、神經外科[16.5％(51/309)]、呼吸內科[9.4％ (29/309)].金黃色葡萄毬菌對萬古黴素、替攷拉寧、奎奴普丁/達福普汀和呋喃妥因的耐藥率≤2.1％,MRSA與對甲氧西林敏感的金黃色葡萄毬菌(MSSA)以及β內酰胺酶暘性金黃色葡萄毬菌與β內酰胺酶陰性金黃色葡萄毬菌間的耐藥性差異無統計學意義(P＞0.05);對複方新諾明的耐藥性MRSA低于MSSA(P ＜0.05),β內酰胺酶暘性低于β內酰胺酶陰性金黃色葡萄毬菌(P＜0.05).對其他抗菌藥物的耐藥性MRSA高于MSSA(P ＜0.05);β內酰胺酶暘性高于β內酰胺酶陰性金黃色葡萄毬菌,但除左鏇氧氟沙星外(P＜0.05),其他差異均無統計學意義(P＞0.05).結論 MRSA和β內酰胺酶暘性金黃色葡萄毬菌的檢齣率和耐藥性較高,臨床應依據藥敏試驗鑑測結果閤理選擇抗菌藥物.
목적 회고성분석담표본중금황색포도구균적림상분포화내약정황,위예방공제조시적제정제공의거.방법 대2009년1월지2013년9월내몽고자치구인민의원림상분리적309주금황색포도구균진행분석,세균감정화약민시험채용VITEK 2 Compact전자동세균배양감정의.결과 내갑양서림금황색포도구균(MRSA)적분리솔위78.6％(243/309),β내선알매양성금황색포도구균분리솔위90.0％(278/309);금황색포도구균적병구래원주요위신경내과[30.7％ (95/309)]、중증감호병방[22.0％(68/309)]、신경외과[16.5％(51/309)]、호흡내과[9.4％ (29/309)].금황색포도구균대만고매소、체고랍저、규노보정/체복보정화부남타인적내약솔≤2.1％,MRSA여대갑양서림민감적금황색포도구균(MSSA)이급β내선알매양성금황색포도구균여β내선알매음성금황색포도구균간적내약성차이무통계학의의(P＞0.05);대복방신낙명적내약성MRSA저우MSSA(P ＜0.05),β내선알매양성저우β내선알매음성금황색포도구균(P＜0.05).대기타항균약물적내약성MRSA고우MSSA(P ＜0.05);β내선알매양성고우β내선알매음성금황색포도구균,단제좌선양불사성외(P＜0.05),기타차이균무통계학의의(P＞0.05).결론 MRSA화β내선알매양성금황색포도구균적검출솔화내약성교고,림상응의거약민시험감측결과합리선택항균약물.
Objective To analyze the clinical distribution and drug resistance of sputum specimens staphylococcus ball.Methods From January 2009 to September 2013,309 strains of clinical separation of staphylococcus aureus were analyzed.The bacteria identification and drug sensitive test were detected by VITEK 2 Compact automatic bacterial culture appraisal instrument.Results The separation rates ofmethicillin resistant staphylococcus aureus(MRSA) and beta-lactamase positive staphylococcus aureus were 78.6％ (243/309) and 90.0％ (278/309) ; the main sourceof staphylococcus aureus was neurology department,accounting for 30.7 ％ (95/309).The resistant rate of staphylococcus aureusto vancomycin,teicoplanin,quinupristin/dafoe leptin andnitrofurantoin was all ＜ 2.1％.There were no significant differences regardingbetween MRSA and methicillin sensitive staphylococcus aureus (MSSA),drug resistancebetween beta lactamase positive staphylococcus aureus and beta lactamase negative staphylococcus aureus (all P ＞ 0.05).Beta lactamase positive staphylococcus aureus was lower than beta lactamase negative staphylococcus aureus (P ＜ 0.05).The drug resistance of MRSA was higher than that of MSSA (P ＜ 0.05).Beta lactamase positive staphylococcus aureus was higher than beta lactamase negative staphylococcus aureus.Conclusion The detective rate and drug resistance of MRSA and beta lactamase positive staphylococcus aureus are high and the reasonable choice ofantibacterial drugs should be based on clinical drug sensitive test monitoring results.
