中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
3期
328-330
,共3页
肺疾病,慢性阻塞性%呼吸衰竭%环氧化酶2%前列腺素E2%磷脂酶A2
肺疾病,慢性阻塞性%呼吸衰竭%環氧化酶2%前列腺素E2%燐脂酶A2
폐질병,만성조새성%호흡쇠갈%배양화매2%전렬선소E2%린지매A2
Pulmonary disease,chronic obstructive%Respiratory failure%Cyclooxygenase-2%Prostaglandin E2%Phospholipases A2
目的 观察慢性阻塞性肺疾病急性加重合并呼吸衰竭患者血清环氧化酶2、前列腺素E2和磷脂酶A2水平变化及意义.方法 选取河北省涿州市医院2011年12月至2012年12月100例慢性阻塞性肺疾病急性加重患者,完全随机分为无呼吸衰竭组(50例)和呼吸衰竭组(50例),另选择20例健康查体者作为健康对照组.观察3组患者血清环氧化酶2、前列腺素E2和磷脂酶A2的变化.结果 呼吸衰竭组和无呼吸衰竭组血清环氧化酶2、前列腺素E2和磷脂酶A2浓度明显高于健康对照组[(158±45)、(132±12)μg/L比(57±12)μg/L,(317±213)、(207±30)ng/L比(103±18)ng/L,(28.2±1.5)、(20.2±1.4)μg/L比(7.0±2.4)μg/L],差异均有统计学意义(均P＜0.05).呼吸衰竭组血清环氧化酶2、前列腺素E2和磷脂酶A2浓度与无呼吸衰竭组比较,差异有统计学意义(P＜0.05).呼吸衰竭组血清环氧化酶2、前列腺素E2水平与磷脂酶A2水平呈正相关(r分别为0.406、0.356,P＜0.05);血清环氧化酶2水平与前列腺素E2水平呈正相关(r为0.848,P＜0.01).结论 慢性阻塞性肺疾病急性加重合并呼吸衰竭患者血清环氧化酶2、前列腺素E2和磷脂酶A2的浓度明显升高,血清环氧化酶2、前列腺素E2和磷脂酶A2三者之间相互关联并相互作用,共同导致呼吸衰竭的发生和发展.
目的 觀察慢性阻塞性肺疾病急性加重閤併呼吸衰竭患者血清環氧化酶2、前列腺素E2和燐脂酶A2水平變化及意義.方法 選取河北省涿州市醫院2011年12月至2012年12月100例慢性阻塞性肺疾病急性加重患者,完全隨機分為無呼吸衰竭組(50例)和呼吸衰竭組(50例),另選擇20例健康查體者作為健康對照組.觀察3組患者血清環氧化酶2、前列腺素E2和燐脂酶A2的變化.結果 呼吸衰竭組和無呼吸衰竭組血清環氧化酶2、前列腺素E2和燐脂酶A2濃度明顯高于健康對照組[(158±45)、(132±12)μg/L比(57±12)μg/L,(317±213)、(207±30)ng/L比(103±18)ng/L,(28.2±1.5)、(20.2±1.4)μg/L比(7.0±2.4)μg/L],差異均有統計學意義(均P＜0.05).呼吸衰竭組血清環氧化酶2、前列腺素E2和燐脂酶A2濃度與無呼吸衰竭組比較,差異有統計學意義(P＜0.05).呼吸衰竭組血清環氧化酶2、前列腺素E2水平與燐脂酶A2水平呈正相關(r分彆為0.406、0.356,P＜0.05);血清環氧化酶2水平與前列腺素E2水平呈正相關(r為0.848,P＜0.01).結論 慢性阻塞性肺疾病急性加重閤併呼吸衰竭患者血清環氧化酶2、前列腺素E2和燐脂酶A2的濃度明顯升高,血清環氧化酶2、前列腺素E2和燐脂酶A2三者之間相互關聯併相互作用,共同導緻呼吸衰竭的髮生和髮展.
목적 관찰만성조새성폐질병급성가중합병호흡쇠갈환자혈청배양화매2、전렬선소E2화린지매A2수평변화급의의.방법 선취하북성탁주시의원2011년12월지2012년12월100례만성조새성폐질병급성가중환자,완전수궤분위무호흡쇠갈조(50례)화호흡쇠갈조(50례),령선택20례건강사체자작위건강대조조.관찰3조환자혈청배양화매2、전렬선소E2화린지매A2적변화.결과 호흡쇠갈조화무호흡쇠갈조혈청배양화매2、전렬선소E2화린지매A2농도명현고우건강대조조[(158±45)、(132±12)μg/L비(57±12)μg/L,(317±213)、(207±30)ng/L비(103±18)ng/L,(28.2±1.5)、(20.2±1.4)μg/L비(7.0±2.4)μg/L],차이균유통계학의의(균P＜0.05).호흡쇠갈조혈청배양화매2、전렬선소E2화린지매A2농도여무호흡쇠갈조비교,차이유통계학의의(P＜0.05).호흡쇠갈조혈청배양화매2、전렬선소E2수평여린지매A2수평정정상관(r분별위0.406、0.356,P＜0.05);혈청배양화매2수평여전렬선소E2수평정정상관(r위0.848,P＜0.01).결론 만성조새성폐질병급성가중합병호흡쇠갈환자혈청배양화매2、전렬선소E2화린지매A2적농도명현승고,혈청배양화매2、전렬선소E2화린지매A2삼자지간상호관련병상호작용,공동도치호흡쇠갈적발생화발전.
Objective To investigate the change and clinical value of cyclooxygenase-2(COX2), prostaglandin E2(PGE2)and phospholipases A2(PLA2)in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) combined with respiratory failure. Methods One hundred patients with AECOPD of hospital of Zhuozhou city from December 2011 to December 2012 were divided into respiratory failure group(n=50)and no respiratory failure group(n=50). Twenty patients with healthy control subjects were selected as control group. The levels of COX2, PGE2 and PLA2 of three groups were detected. Results The levels of blood COX2, PGE2 and PLA2 in respiratory failure group and no respiratory failure group were higher than those in healthy control group [(158±45),(132±12)μg/L vs (57±12)μg/L ;(317±213),(207±30)ng/L vs (103±18)ng/L;(28.2±1.5), (20.2±1.4)μg/L vs (7.0±2.4)μg/L], there were significant differences(P<0.05). There were significant differences on the levels of blood COX2, PGE2 and PLA2 in respiratory failure group when compared with that in no respiratory failure group (P<0.05). There was a positive relation among COX2, PGE2 and PLA2 in respiratory failure group (r=0.406, 0.356,P＜0.05); and there was a positive relation between COX2 and PGE2 (r=0.848, P＜0.01). Conclusion The levels of COX2, PGE2 and PLA2 of respiratory failure group are significantly increased and have influence on respiratory failure.
