中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
3期
418-420
,共3页
中药%不良反应%合理用药
中藥%不良反應%閤理用藥
중약%불량반응%합리용약
Traditional Chinese medicine%Adverse reactions%Rational use of drugs
目的 了解本院中药不良反应发生特点及一般规律,预防不良反应的发生,促进临床合理用药.方法 采用回顾性研究方法,收集山东省烟台市莱阳中心医院2010年1月至2011年9月的108例中药不良反应报告,分别从患者的一般情况、给药途径、药物种类及临床表现等方面进行统计分析.结果 不良反应报告中,51～60岁年龄段发生不良反应的比例最高,占29.6%(32/108);静脉滴注最易导致不良反应,占66.7%(76例),其次为口服给药,占22.2%(24例);临床表现以皮肤及其附件损害最常见,占39.5%;不良反应发生在1 d以内者89例,占82.4%.中药注射剂不良反应发生率排名前3位的分别是艾迪注射液(9.3%)、丹红注射液(5.6%)、生脉注射液(4.6%).中药口服制剂不良反应发生率排前3位的分别是茴三硫胶囊(6.5%)、先声咳喘宁(5.6%)、舒肝宁(3.7%).给药途径以静脉滴注(72例,占66.7%)和口服给药(24例,占22.2%)为主.108例不良反应报告中,治愈40例,好转67例,无死亡病例,1例严重不良反应留有后遗症.结论 药品不良反应与多种因素有关,应辨证看待中药不良反应,加强对中药不良反应监测,提高临床用药安全.
目的 瞭解本院中藥不良反應髮生特點及一般規律,預防不良反應的髮生,促進臨床閤理用藥.方法 採用迴顧性研究方法,收集山東省煙檯市萊暘中心醫院2010年1月至2011年9月的108例中藥不良反應報告,分彆從患者的一般情況、給藥途徑、藥物種類及臨床錶現等方麵進行統計分析.結果 不良反應報告中,51～60歲年齡段髮生不良反應的比例最高,佔29.6%(32/108);靜脈滴註最易導緻不良反應,佔66.7%(76例),其次為口服給藥,佔22.2%(24例);臨床錶現以皮膚及其附件損害最常見,佔39.5%;不良反應髮生在1 d以內者89例,佔82.4%.中藥註射劑不良反應髮生率排名前3位的分彆是艾迪註射液(9.3%)、丹紅註射液(5.6%)、生脈註射液(4.6%).中藥口服製劑不良反應髮生率排前3位的分彆是茴三硫膠囊(6.5%)、先聲咳喘寧(5.6%)、舒肝寧(3.7%).給藥途徑以靜脈滴註(72例,佔66.7%)和口服給藥(24例,佔22.2%)為主.108例不良反應報告中,治愈40例,好轉67例,無死亡病例,1例嚴重不良反應留有後遺癥.結論 藥品不良反應與多種因素有關,應辨證看待中藥不良反應,加彊對中藥不良反應鑑測,提高臨床用藥安全.
목적 료해본원중약불량반응발생특점급일반규률,예방불량반응적발생,촉진림상합리용약.방법 채용회고성연구방법,수집산동성연태시래양중심의원2010년1월지2011년9월적108례중약불량반응보고,분별종환자적일반정황、급약도경、약물충류급림상표현등방면진행통계분석.결과 불량반응보고중,51～60세년령단발생불량반응적비례최고,점29.6%(32/108);정맥적주최역도치불량반응,점66.7%(76례),기차위구복급약,점22.2%(24례);림상표현이피부급기부건손해최상견,점39.5%;불량반응발생재1 d이내자89례,점82.4%.중약주사제불량반응발생솔배명전3위적분별시애적주사액(9.3%)、단홍주사액(5.6%)、생맥주사액(4.6%).중약구복제제불량반응발생솔배전3위적분별시회삼류효낭(6.5%)、선성해천저(5.6%)、서간저(3.7%).급약도경이정맥적주(72례,점66.7%)화구복급약(24례,점22.2%)위주.108례불량반응보고중,치유40례,호전67례,무사망병례,1례엄중불량반응류유후유증.결론 약품불량반응여다충인소유관,응변증간대중약불량반응,가강대중약불량반응감측,제고림상용약안전.
Objective To understand the characteristic and general rules of Chinese medicine adverse reaction to prevent the occurrence of adverse reactions. Methods Totally 108 cases of traditional Chinese medicine ADR reports from January 2010 to September 2011 in Yantai Laiyang Central Hospital of Shandong province were collected, including the patient's general situation, dosing method, types of drugs and the clinical manifestation were analyzed. Results The male ADR incidence was significantly higher than female. Age 51 to 60 years old had the highest percentage of ADR, accounting for 29.6% (32/108). Intravenous drips that the most easily led to ADR were 66.7%, followed by oral drugs that were 22.2%. The skin and its accessories damage was the most common (39.5%) ADR Clinical manifestations. ADR occurring mainly within the one day accounted for 82.4% (89 cases). The top three ADR incidence of injection preparations of Chinese medicine were Aidi injection (9.3%), Danhong injection (5.6%) and Shengmai injection (4.6%). The top three ADR incidence of oral preparations of Chinese medicine were anethole capsule (6.5%), Kechuanning oral liquid (5.6%) and shuganning capsule (3.7%). 40 cases of 108 cases of ADR reports were cured, 67 cases were improved and one case of severe adverse reactions had sequela without deaths. Conclusion Adverse drug reactions are related to multiple factors. We should collect the traditional Chinese medicine adverse reactions, strengthen the ADR monitoring and improve clinical medication safety.
