中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
4期
545-547
,共3页
张海萌%隋霜%李小英%黄莺
張海萌%隋霜%李小英%黃鶯
장해맹%수상%리소영%황앵
子痫前期%同型半胱氨酸%叶酸%维生素B12
子癇前期%同型半胱氨痠%葉痠%維生素B12
자간전기%동형반광안산%협산%유생소B12
Preeclampsia%Homocysteine%Folic acid%Vitamin B12
目的 分析维吾尔族子痫前期患者血浆总同型半胱氨酸(tHcy)及其代谢因子叶酸、维生素B12水平与子痫前期病情轻重程度的关系.方法 选择维吾尔族正常晚期妊娠者31例、子痫前期轻度33例、子痫前期重度36例,分别测定其血浆tHcy和血清叶酸、维生素B12水平.结果 血浆tHcy水平在正常对照组、子痫前期轻度组、子痫前期重度组3组之间差异有统计学意义[分别为(9±3),(13±4),(16±4) μmol/L](F=29.688,P＜0.01),且两两比较差异有统计学意义.叶酸水平3组间差异无统计学意义(F=1.176,P＞0.05).子痫前期轻度组的维生素B12水平明显低于正常对照组和子痫前期重度组[(154±64) ng/L比(215±79),(213 ±95) ng/L],差异有统计学意义(P＜0.01).Pearson相关分析结果显示,3组中血浆tHcy水平与血清叶酸、维生素B12水平之间不具有相关关系(P＞0.05);Spearman秩相关分析表明,Hcy与子痫前期病情轻重呈正相关(r=0.650,P=0.000),叶酸、维生素B12与子痫前期病情轻重相关分析无统计学意义(r=0.089,-0.018,P=0.380,0.859).结论 维吾尔族子痫前期患者的tHcy水平明显增高,tHcy水平与病情轻重程度有关,tHcy水平高者病情重.
目的 分析維吾爾族子癇前期患者血漿總同型半胱氨痠(tHcy)及其代謝因子葉痠、維生素B12水平與子癇前期病情輕重程度的關繫.方法 選擇維吾爾族正常晚期妊娠者31例、子癇前期輕度33例、子癇前期重度36例,分彆測定其血漿tHcy和血清葉痠、維生素B12水平.結果 血漿tHcy水平在正常對照組、子癇前期輕度組、子癇前期重度組3組之間差異有統計學意義[分彆為(9±3),(13±4),(16±4) μmol/L](F=29.688,P＜0.01),且兩兩比較差異有統計學意義.葉痠水平3組間差異無統計學意義(F=1.176,P＞0.05).子癇前期輕度組的維生素B12水平明顯低于正常對照組和子癇前期重度組[(154±64) ng/L比(215±79),(213 ±95) ng/L],差異有統計學意義(P＜0.01).Pearson相關分析結果顯示,3組中血漿tHcy水平與血清葉痠、維生素B12水平之間不具有相關關繫(P＞0.05);Spearman秩相關分析錶明,Hcy與子癇前期病情輕重呈正相關(r=0.650,P=0.000),葉痠、維生素B12與子癇前期病情輕重相關分析無統計學意義(r=0.089,-0.018,P=0.380,0.859).結論 維吾爾族子癇前期患者的tHcy水平明顯增高,tHcy水平與病情輕重程度有關,tHcy水平高者病情重.
목적 분석유오이족자간전기환자혈장총동형반광안산(tHcy)급기대사인자협산、유생소B12수평여자간전기병정경중정도적관계.방법 선택유오이족정상만기임신자31례、자간전기경도33례、자간전기중도36례,분별측정기혈장tHcy화혈청협산、유생소B12수평.결과 혈장tHcy수평재정상대조조、자간전기경도조、자간전기중도조3조지간차이유통계학의의[분별위(9±3),(13±4),(16±4) μmol/L](F=29.688,P＜0.01),차량량비교차이유통계학의의.협산수평3조간차이무통계학의의(F=1.176,P＞0.05).자간전기경도조적유생소B12수평명현저우정상대조조화자간전기중도조[(154±64) ng/L비(215±79),(213 ±95) ng/L],차이유통계학의의(P＜0.01).Pearson상관분석결과현시,3조중혈장tHcy수평여혈청협산、유생소B12수평지간불구유상관관계(P＞0.05);Spearman질상관분석표명,Hcy여자간전기병정경중정정상관(r=0.650,P=0.000),협산、유생소B12여자간전기병정경중상관분석무통계학의의(r=0.089,-0.018,P=0.380,0.859).결론 유오이족자간전기환자적tHcy수평명현증고,tHcy수평여병정경중정도유관,tHcy수평고자병정중.
Objective To analyze the relationship between the levels of plasma total homocysteine (Hcy) and the metabolic factors of folic acid and vitamin B12 in uygur patients with the severity of preeclampsia.Methods A total of 31 cases of the third trimester of normal pregnancy,33 cases of mild preeclampsia and 36 cases of severe preeclampsia were selected.Results Hcy levels were statistically different among the normal control group,mild preeclampsia group and severe preeclampsia group [(9 ± 3),(13 ±4),(16 ±4)μmol/L,respectively] (P ＜ 0.05) ; folate levels were no different among the three groups (F =1.176,P ＞ 0.05),vitamin B12 levels in mild preeclampsia were lower than that in control group and severe preeclampsia[(154 ±64)ng/L vs (215 ± 79),(213 ± 95) ng/L] (P ＜ 0.05).There was no correlation among the Hcy,folic acidand vitamin B12 (P ＞ 0.05).Hcy with preeclampsia severity was positively correlated,folic acid,vitamin B12 and preeclampsia severity was not correlated,and the difference was statistically significant (P ＞ 0.05).Conclusion The levels of tHcy is related to the severity of preeclampsia.
