中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
4期
550-553
,共4页
精神病%血脂%依折麦布%降血脂
精神病%血脂%依摺麥佈%降血脂
정신병%혈지%의절맥포%강혈지
Mental illness%Lipids%Ezetimibe%Hypolipidemic
目的 探讨依折麦布对长期接受抗精神病药物治疗的精神病患者血脂的调节作用.方法 将2010年4月至2013年8月乌鲁木齐市第四人民医院收治的伴有高血脂的94例精神病患者,按照随机数表法随机分为观察组和对照组,各47例.对照组接受辛伐他汀20 mg/d治疗,观察组患者服用10 mg/d辛伐他汀的同时加用依折麦布10 mg/d.治疗8周后对2组患者血脂及血液流变学指标进行对比分析.结果 经治疗,除载脂蛋白A外2组患者的血脂水平均有不同程度的降低(P＜0.05),其中观察组治疗后总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白B均低于对照组[(5.0±0.8) mmol/L比(5.2±0.7)mmol/L、(1.6±0.8)mmol/L比(1.9 ±0.8)mmol/L、(1.11±0.34) mmol/L比(1.07±0.49) mmol/L、(2.42±0.83) mmol/L比(3.08±0.67) mmol/L、(1.15-±0.31) g/L比(1.34 ±0.49)g/L](均P＜0.05).观察组和对照组患者的血液黏度(高切全血黏度、低切全血黏度及血浆黏度)较治疗前有所降低[观察组:(4.2 ±0.8)mPa·s比(6.5-±0.8)mPa·s,(12.6±1.2)mPa·s比(22.6±5.2)mPa·s,(1.46±0.25) mPa·s比(1.89-±0.36) mPa·s;对照组:(5.5±0.9)mPa·s比(6.6±1.0)mPa·s,(16.3±7.2)mPa·s比(24.3-±6.2)mPa· s,(1.76±0.34)mPa·s比(1.93±0.57) mPa·s](P＜0.05),观察组治疗后血液黏度低于对照组,差异有统计学意义(P＜0.05).结论 依折麦布对长期服用抗精神病药物导致的高血脂有调节作用,疗效显著且较为安全.
目的 探討依摺麥佈對長期接受抗精神病藥物治療的精神病患者血脂的調節作用.方法 將2010年4月至2013年8月烏魯木齊市第四人民醫院收治的伴有高血脂的94例精神病患者,按照隨機數錶法隨機分為觀察組和對照組,各47例.對照組接受辛伐他汀20 mg/d治療,觀察組患者服用10 mg/d辛伐他汀的同時加用依摺麥佈10 mg/d.治療8週後對2組患者血脂及血液流變學指標進行對比分析.結果 經治療,除載脂蛋白A外2組患者的血脂水平均有不同程度的降低(P＜0.05),其中觀察組治療後總膽固醇、三酰甘油、高密度脂蛋白膽固醇、低密度脂蛋白膽固醇、載脂蛋白B均低于對照組[(5.0±0.8) mmol/L比(5.2±0.7)mmol/L、(1.6±0.8)mmol/L比(1.9 ±0.8)mmol/L、(1.11±0.34) mmol/L比(1.07±0.49) mmol/L、(2.42±0.83) mmol/L比(3.08±0.67) mmol/L、(1.15-±0.31) g/L比(1.34 ±0.49)g/L](均P＜0.05).觀察組和對照組患者的血液黏度(高切全血黏度、低切全血黏度及血漿黏度)較治療前有所降低[觀察組:(4.2 ±0.8)mPa·s比(6.5-±0.8)mPa·s,(12.6±1.2)mPa·s比(22.6±5.2)mPa·s,(1.46±0.25) mPa·s比(1.89-±0.36) mPa·s;對照組:(5.5±0.9)mPa·s比(6.6±1.0)mPa·s,(16.3±7.2)mPa·s比(24.3-±6.2)mPa· s,(1.76±0.34)mPa·s比(1.93±0.57) mPa·s](P＜0.05),觀察組治療後血液黏度低于對照組,差異有統計學意義(P＜0.05).結論 依摺麥佈對長期服用抗精神病藥物導緻的高血脂有調節作用,療效顯著且較為安全.
목적 탐토의절맥포대장기접수항정신병약물치료적정신병환자혈지적조절작용.방법 장2010년4월지2013년8월오로목제시제사인민의원수치적반유고혈지적94례정신병환자,안조수궤수표법수궤분위관찰조화대조조,각47례.대조조접수신벌타정20 mg/d치료,관찰조환자복용10 mg/d신벌타정적동시가용의절맥포10 mg/d.치료8주후대2조환자혈지급혈액류변학지표진행대비분석.결과 경치료,제재지단백A외2조환자적혈지수평균유불동정도적강저(P＜0.05),기중관찰조치료후총담고순、삼선감유、고밀도지단백담고순、저밀도지단백담고순、재지단백B균저우대조조[(5.0±0.8) mmol/L비(5.2±0.7)mmol/L、(1.6±0.8)mmol/L비(1.9 ±0.8)mmol/L、(1.11±0.34) mmol/L비(1.07±0.49) mmol/L、(2.42±0.83) mmol/L비(3.08±0.67) mmol/L、(1.15-±0.31) g/L비(1.34 ±0.49)g/L](균P＜0.05).관찰조화대조조환자적혈액점도(고절전혈점도、저절전혈점도급혈장점도)교치료전유소강저[관찰조:(4.2 ±0.8)mPa·s비(6.5-±0.8)mPa·s,(12.6±1.2)mPa·s비(22.6±5.2)mPa·s,(1.46±0.25) mPa·s비(1.89-±0.36) mPa·s;대조조:(5.5±0.9)mPa·s비(6.6±1.0)mPa·s,(16.3±7.2)mPa·s비(24.3-±6.2)mPa· s,(1.76±0.34)mPa·s비(1.93±0.57) mPa·s](P＜0.05),관찰조치료후혈액점도저우대조조,차이유통계학의의(P＜0.05).결론 의절맥포대장기복용항정신병약물도치적고혈지유조절작용,료효현저차교위안전.
Objective To investigate the regulation of blood lipids during receiving long-term antipsychotic treatment psychiatric patients by ezetimibe.Methods From April 2010 to August 2013,94 cases of mental illness associated with high cholesterol in fourth people's hospital of Urunqi were as a research object.According to the random number table method,the patients were randomly divided into two groups,each had 47 cases.The control group received simvastatin 20 mg/d,observation group accepted simvastatin 10 mg/d and ezetimibe 10 mg/d.After treatment for 8 weeks,blood rheology in two groups of patients were compared and analyzed.Results After treatment,except Apo-A,the lipid levels of two groups decreased to varying degrees(P ＜ 0.05).The Total cholesterol,triglycerides,high-density lipoprotein cholesterol,low density lipoprotein cholesterol and apolipoprotein B in the observation group after treatment were all lower than those in the control group [(5.0 ± 0.8) mmol/L vs (5.2±0.7)mmol/L,(1.6 ±0.8)mmol/L vs (1.9 ±0.8)mmol/L,(1.11 ±0.34)mmol/L vs (1.07 ± 0.49) mmol/L,(2.42 ±0.83)mmol/L vs 3.08 ± 0.67)mmol/L,(1.15 ±0.31)g/L vs (1.34 ± 0.49) g/L] (all P ＜ 0.05).The blood viscosity of the observation group and control group were all lower than before treatment [observation group:(4.2 ±0.8)mPa · s vs (6.5 ±0.8)mPa · s,(12.6 ± 1.2)mPa · s vs (22.6 ±5.2)mPa · s,(1.46 ± 0.25) mPa · s vs (1.89 ± 0.36) mPa · s ; control group:(5.5 ± 0.9) mPa · s vs (6.6 ± 1.0) mPa · s,(16.3±7.2)mPa·svs (24.3±6.2)mPa· s,(1.76±0.34)mPa· s vs (1.93 ±0.57)mPa· s] (allP＜ 0.05),after treatment blood viscosity of the observation group was lower than the control group,the difference was statistically significant (P ＜ 0.05).Conclusion Ezetimibe has a significant effect and security effect for the high cholesterol which caused by long-term use of antipsychotics.
