中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
5期
710-712
,共3页
孟庆杰%张炜%尹吉明%郭通航
孟慶傑%張煒%尹吉明%郭通航
맹경걸%장위%윤길명%곽통항
弱精子症%精索静脉曲张%植物药%迈之灵
弱精子癥%精索靜脈麯張%植物藥%邁之靈
약정자증%정색정맥곡장%식물약%매지령
Asthenospermia%Varicocele%Botanicals%Aescuven forte tablets
目的 评价迈之灵治疗轻度精索静脉曲张伴弱精子症的临床效果.方法 选取2010年2月至2012年6月在安徽省宿州市立医院男性科门诊就诊的98例诊断为轻度VC伴弱精子症的患者,给予植物药制剂迈之灵片口服,150 mg/次,2次/d,6周为1个疗程,共治疗2个疗程,分别于治疗前和治疗后12周,采用计算机辅助精子自动分析系统进行精液参数分析,以评价治疗效果.结果 入选患者98例.共95例患者完成全部治疗疗程,中断或放弃治疗者3例,未纳入统计.除11例患者精液质量未见明显改善外,其余84例患者精液质量均有不同程度改善,有效率为88.4％(84/95).其中,精子浓度和精液量治疗前后差异无统计学意义(P＞0.05),精子总活力、前向运动精子率、快速前向运动精子率(直线速度＞35 μm/s)、平均运动速度(VAP)、直线运动速度(VSL)、曲线运动速度(VCL)等主要精子运动参数指标在治疗后均有明显改善[(40±14)％比(28±l2)％,(30±11)％比(18±9)％,(18±9)％比(l0±6)％,(26±6)μm/s比(21 ±4)μm/s,(24±6)μm/s比(21±5)μm/s,(32±6)μm/s比(26±6)μm/s](均P＜0.01).治疗期间及治疗后3个月内有12例患者配偶怀孕,怀孕率为12.6％ (12/95).结论 迈之灵片对轻度VC伴弱精子症具有良好的治疗效果,且无明显不良反应.
目的 評價邁之靈治療輕度精索靜脈麯張伴弱精子癥的臨床效果.方法 選取2010年2月至2012年6月在安徽省宿州市立醫院男性科門診就診的98例診斷為輕度VC伴弱精子癥的患者,給予植物藥製劑邁之靈片口服,150 mg/次,2次/d,6週為1箇療程,共治療2箇療程,分彆于治療前和治療後12週,採用計算機輔助精子自動分析繫統進行精液參數分析,以評價治療效果.結果 入選患者98例.共95例患者完成全部治療療程,中斷或放棄治療者3例,未納入統計.除11例患者精液質量未見明顯改善外,其餘84例患者精液質量均有不同程度改善,有效率為88.4％(84/95).其中,精子濃度和精液量治療前後差異無統計學意義(P＞0.05),精子總活力、前嚮運動精子率、快速前嚮運動精子率(直線速度＞35 μm/s)、平均運動速度(VAP)、直線運動速度(VSL)、麯線運動速度(VCL)等主要精子運動參數指標在治療後均有明顯改善[(40±14)％比(28±l2)％,(30±11)％比(18±9)％,(18±9)％比(l0±6)％,(26±6)μm/s比(21 ±4)μm/s,(24±6)μm/s比(21±5)μm/s,(32±6)μm/s比(26±6)μm/s](均P＜0.01).治療期間及治療後3箇月內有12例患者配偶懷孕,懷孕率為12.6％ (12/95).結論 邁之靈片對輕度VC伴弱精子癥具有良好的治療效果,且無明顯不良反應.
목적 평개매지령치료경도정색정맥곡장반약정자증적림상효과.방법 선취2010년2월지2012년6월재안휘성숙주시립의원남성과문진취진적98례진단위경도VC반약정자증적환자,급여식물약제제매지령편구복,150 mg/차,2차/d,6주위1개료정,공치료2개료정,분별우치료전화치료후12주,채용계산궤보조정자자동분석계통진행정액삼수분석,이평개치료효과.결과 입선환자98례.공95례환자완성전부치료료정,중단혹방기치료자3례,미납입통계.제11례환자정액질량미견명현개선외,기여84례환자정액질량균유불동정도개선,유효솔위88.4％(84/95).기중,정자농도화정액량치료전후차이무통계학의의(P＞0.05),정자총활력、전향운동정자솔、쾌속전향운동정자솔(직선속도＞35 μm/s)、평균운동속도(VAP)、직선운동속도(VSL)、곡선운동속도(VCL)등주요정자운동삼수지표재치료후균유명현개선[(40±14)％비(28±l2)％,(30±11)％비(18±9)％,(18±9)％비(l0±6)％,(26±6)μm/s비(21 ±4)μm/s,(24±6)μm/s비(21±5)μm/s,(32±6)μm/s비(26±6)μm/s](균P＜0.01).치료기간급치료후3개월내유12례환자배우부잉,부잉솔위12.6％ (12/95).결론 매지령편대경도VC반약정자증구유량호적치료효과,차무명현불량반응.
Objective To evaluate the clinical effect of botanical drug aescuven forte tablets in mild varicocele with asthenospermia.Methods From February 2010 to June 2012 in andrology clinic,98 patients diagnosed of mild varicocele with asthenospermia were given botanical aescuven forte tablets.Before treatment and 12 weeks after treatment,computer-aided sperm analysis system automatically (CASA) was observed.Results A total of 95 patients completed the treatment,3 cases of interrupt or abandon treatment were not included.84 cases were improved with semen quality and the effective rate was 88.4％ (84/95).Among them,the sperm concentration and semen volume before and after treatment was no significantly different (P ＞ 0.05).Sperm total motility (PR ± NP),forward motility rate (PR),fast forward motion of sperm rate (VSL ＞ 35 μm/s),the average velocity (VAP),straight-line velocity (VSL),curvilinear velocity (VCL) and other major indicators of sperm motion parameters were all significantly improved after treatment [(40 ± 14)％ vs (28 ± 12)％,(30 ± 11)％ vs (18 ± 9)％,(18 ±9)％ vs (10 ±6)％,(26 ±6) μm/s vs (21 ±4) μm/s,(24 ± 6) μm/s vs (21 ± 5) μm/s,(32 ± 6) μm/s vs (26 ± 6) μm/s] (P ＜ 0.01).During treatment and 3 months after treatment,the pregnancy rate was 12.6％ (12/95).Conclusion The botanical drug aescuven forte tablets has a good therapeutic effect on mild varicocele.
